A phase II study of HMB/Arg/Gln against oral mucositis induced by chemoradiotherapy for patients with head and neck cancer

Abstract

UMIN000016453.

β-Hydroxy-β-methyl Butyrate/L-Arginine/L-Glutamine Supplementation for Preventing Hand–Foot Skin Reaction in Sorafenib for Advanced Hepatocellular Carcinoma

“…Matsuhashi et al reported that such supplementation was apparently effective in the treatment of anti-epidermal growth factor receptor antibody-associated skin disorder (22). Yokota et al conducted a phase II study that showed the efficacy of HMB, L-arginine and L-glutamine supplementation for chemoradiotherapyinduced oral mucositis in patients with head and neck cancer (23). These findings would suggest a preventive effect of HMB, L-arginine and L-glutamine against HFSR in patients with HCC treated with sorafenib.…”

Proline-dependent regulation of collagen metabolism

“…Recent clinical and preclinical data suggested that arginine (Arg) and ornithine (Orn) supplementation are the most effective in increasing collagen deposition. However, whether this was accomplished by conversion to proline has not been confirmed [25,33]. It is known that glutamine plays a key role in protein metabolism.…”

Nutritional interventions for oral mucositis: a systematic literature review

“…Of the 915 articles, 893 were potentially eligible for inclusion and 802 were then excluded based on title and abstract. After full texts were obtained and eligibility criteria applied to the remaining 91 articles, 23 articles 23,24,28‐49 were included in the review (total unique study participants n = 7605; Table 1). These included five systematic reviews with meta‐analyses 23,41,43‐45 ; six systematic reviews, 24,34,35,38,39,46 two randomised controlled trials (RCTs) 30,33 ; one non‐randomised controlled trial 48 ; four prospective cohort studies 32,37,42,47 ; two retrospective cohort studies 29,31 and three case series 28,36,40 …”

“…Articles investigating more than one intervention were eligible to fall into multiple intervention review areas. These included: oral cryotherapy (five studies; n = 1777) 29,30,39,41,44 ; elemental oral nutrition supplements (five studies; n = 186) 31,32,36,37,42 ; beta‐hydroxy‐beta‐methylbutyrate‐, arginine‐ and glutamine‐enriched (HMB/Arg/Gln) powdered supplement (two studies; n = 64) 47,48 ; immune‐modulating oral nutrition supplements (one study; n = 40) 28 ; fat‐soluble vitamins (two studies; n = 103) 23,46 ; glutamine supplementation (five studies; n = 2050) 24,33,38,40,46 ; zinc supplementation (three studies; n = 1009) 34,43,46 ; miscellaneous mineral supplements (two studies; n = 1188) 34,46 and honey (three studies; n = 1292) 35,45,46 …”

“…One negative quality prospective cohort study 47 and one neutral quality non‐randomised controlled trial 48 were identified (total n = 64) investigating (HMB/Arg/Gln) supplements for oral mucositis management. Both articles 47,48 used the same HMB/Arg/Gln powdered supplement containing 1.2 g/β‐hydroxy‐β‐methylbutyrate, 7 g/arginine and 7 g/glutamine per 24 g serve.…”