A phase II trial of induction chemotherapy with cisplatin, docetaxel, and capecitabine followed by concurrent cisplatin-radiotherapy in advanced nasopharyngeal carcinoma.

Yamouni, M.; Beldjilali, Y.; Benhadji, Karim A.; Khellafi, H.; Betkaoui, F.; Kaid, Y.; Benchlef, L.; Daim, F. Z.; Toubal, S.; Boukerche, A.; Djellali, L.

doi:10.1200/jco.2011.29.15_suppl.5543

Cited by 3 publications

(2 citation statements)

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“…Recently, an unpublished phase II study [36] concluded highly similar results (improvement of OS, disease-free survival and metastasis-free survival, not relapse-free survival) of NACT (two to four cycles of cisplatin and 5-fluorouracil or cisplatin and docetaxel every 3 weeks) plus RT versus RT alone. In addition, other combination forms of NACT from several uncontrolled phase II studies, for example, capecitabine plus cisplatin [37], capecitabine plus cisplatin and docetaxel [38] and carboplatin and paclitaxel [39], showed high response rate with manageable toxic effects. But the efficacy and toxic According to existing studies and this meta-analysis, no encouraging findings of AC in OS and DMR were observed.…”

Section: Grade 3 and Higher Adverse Eventsmentioning

confidence: 99%

Significant efficacies of neoadjuvant and adjuvant chemotherapy for nasopharyngeal carcinoma by meta-analysis of published literature-based randomized, controlled trials

et al. 2013

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Section: Grade 3 and Higher Adverse Eventsmentioning

confidence: 99%

Significant efficacies of neoadjuvant and adjuvant chemotherapy for nasopharyngeal carcinoma by meta-analysis of published literature-based randomized, controlled trials

et al. 2013

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“…Chan et al 28 reported complete remission rates of 100% in his study, while Paccagnella et al 32 , Cho et al 33 and Yamouni et al 34 reported complete remission rates of 50% and 48% and 76.8%, respectively.…”

Section: Discussionmentioning

confidence: 93%

Neoadjuvant Docetaxel, Cisplatin and Fluorouracil followed by Concurrent Cisplatin Intensity Modulated Radiation Therapy in Treatment of Locally Advanced Nasopharyngeal Carcinoma

Ibrahim

Zagloul

2013

Kasr-Al-Aini J.of Clin. Onc. and Nuc. Med.

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New aspects of induction chemotherapy for head and neck cancer: POSTASCO 2011

Mumme

Laban

Knecht

2012

Eur Arch Otorhinolaryngol

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Treatment options of patients with advanced head and neck cancer developed in the last years. Surgical approaches with or without radiotherapy used to be the standard therapy for a long time. Calls for organ preservation, poor overall survival and unsatisfactory quality of life made changes in this therapy regime necessary. Systemical approaches were evaluated, first concepts of platinum-based chemotherapy paired with 5-fluorouracil (PF) made up the basis of induction chemotherapy (ICT). Hypothesized advantage of this regime was improvement in local and distant tumor responsiveness with an acceptable toxicity profile. Further investigations proved the addition of docetaxel (TPF) superior to PF, which presents the gold standard of current induction chemotherapy regimes. Long-term results underlining well-known aspects of this regime as well as new approaches of induction chemotherapy were published at ASCO 2011, including the addition of bioimmunotherapy to radiotherapy, adding nanoparticle-bound albumin to chemotherapy and investigations in toxicity reduction. Further investigations are still made not only to increase survival outcomes and local control but also to improve quality of life by reducing acute and late toxicities.

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A phase II trial of induction chemotherapy with cisplatin, docetaxel, and capecitabine followed by concurrent cisplatin-radiotherapy in advanced nasopharyngeal carcinoma.

Cited by 3 publications

References 0 publications

Significant efficacies of neoadjuvant and adjuvant chemotherapy for nasopharyngeal carcinoma by meta-analysis of published literature-based randomized, controlled trials

Significant efficacies of neoadjuvant and adjuvant chemotherapy for nasopharyngeal carcinoma by meta-analysis of published literature-based randomized, controlled trials

Neoadjuvant Docetaxel, Cisplatin and Fluorouracil followed by Concurrent Cisplatin Intensity Modulated Radiation Therapy in Treatment of Locally Advanced Nasopharyngeal Carcinoma

New aspects of induction chemotherapy for head and neck cancer: POSTASCO 2011

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