Abbreviations & Acronyms AE = adverse events AFP = alpha-feto protein BEP = bleomycin, etoposide and cisplatin CINV = chemotherapy-induced nausea and vomiting CR = complete response GCT = germ cell tumor HCG = human chorionic gonadotropin HDCT = high-dose chemotherapy IGCCCG = International Germ Cell Cancer Collaborative Group LN = lymph node NED = no evidence of disease NC = no change of visible disease NCm-= no change of visible disease with serum tumor marker normalization NCm+ = no change of visible disease without serum tumor marker normalization OS = overall survival PD = progressive disease PFS = progression-free survival PR = partial response PRm-= partial response with marker normalization PRm+ = partial response without marker normalization PTX = paclitaxel RPLND = retroperitoneal lymph node dissection STM = serum tumor marker TIN = paclitaxel, ifosfamide and nedaplatin TIP = paclitaxel, ifosfamide and cisplatin TRD = treatment-related deaths VeIP = vinblastine, ifosfamide and cisplatin VIP = etoposide, ifosfamide and cisplatin Objectives: To investigate the efficacy of combined regimen with paclitaxel, ifosfamide and nedaplatin as salvage chemotherapy in patients with cisplatin-refractory or multiple relapsed germ cell tumors. Methods: A total of 65 patients refractory to cisplatin-based chemotherapy or with relapse after induction or salvage chemotherapy received paclitaxel 210 mg/m 2 on day 1, ifosfamide 1.2 g/m 2 on days 2-6 and nedaplatin 100 mg/m 2 on day 2 of a 3-week cycle. The primary and secondary end-points were the response rate and overall survival, respectively. Results: Paclitaxel, ifosfamide and nedaplatin therapy was carried out as second-line therapy in 17 patients, third-line in 31 and fourth-line or later in 17. Patients were pretreated with a median of six cycles of platinum-based chemotherapy (range 3-15 cycles). The overall response rate was 62.9%, including one patient with complete response and 38 with partial response. Serum tumor marker levels normalized in 35 (56.5%) patients. Overall survival at a median follow up of 34 months was 59.3%, and median time to progression was 12 months. Multivariate analysis showed that serum tumor marker normalization was the only independent predictor of better progression-free survival and overall survival. Grade 3/4 of neutropenia, anemia and thrombocytopenia was observed in 96.9%, in 81.5%, and in 90.8% of patients, respectively. Conclusion: Paclitaxel, ifosfamide and nedaplatin chemotherapy appears to be effective when used as first or second salvage treatment in advanced relapsed germ cell tumors. Even after fourth-line therapy, patients with serum tumor marker normalization might have a chance for a cure.