A Phase Inversion‐Based Microfluidic Fabrication of Helical Microfibers towards Versatile Artificial Abdominal Skin

Liu, Jidong; Du, Xiang‐Yun; Chen, Su

doi:10.1002/ange.202110888

Cited by 5 publications

(3 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…106 Additionally, to prevent incisional hernia formation and promote wound healing without adhesion, a flexible, stretchable, biocompatible helical hydrogel microfiber was prepared and applied to artificial abdominal skin (Figure 9C). 108 In addition to wound treatment, bone injury is another common globally disease that lacks effective treatments, which is often caused by traffic accidents or bone diseases. Since tissue engineered scaffolds have been widely used in the treatment of bone defects, hydrogel microfiber scaffolds with photothermal response have been developed for bone regeneration 58 .…”

Section: Biosensorsmentioning

confidence: 99%

See 1 more Smart Citation

Responsive hydrogel microfibers for biomedical engineering

et al. 2022

View full text Add to dashboard Cite

Responsive hydrogel microfibers can realize multiple controllable changes in shapes or properties under the stimulation of the surrounding environment, and are called as intelligent biomaterials. Recently, these responsive hydrogel microfibers have been proved to possess significant biomedical values, and remarkable progress has been achieved in biomedical engineering applications, including drug delivery, biosensors and clinical therapy, etc. In this review, the latest research progress and application prospects of responsive hydrogel microfibers in biomedical engineering are summarized. We first introduce the common preparation strategies of responsive hydrogel microfibers. Subsequently, the response characteristics and the biomedical applications of these materials are discussed. Finally, the present opportunities and challenges as well as the prospects for future development are critically analyzed.

show abstract

Section: Biosensorsmentioning

confidence: 99%

Section: Author Contributionsmentioning

confidence: 99%

Responsive hydrogel microfibers for biomedical engineering

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Typical solidification mechanisms include ionic or chemical cross-linking, [11] photopolymerization, [12] and phase separation. [13] Helical fibers are formed in MST via the liquid rope coiling effect. [14,15] This hydrodynamic instability results in helices with large pitch lengths.…”

mentioning

confidence: 99%

Centrifugal Assembly of Helical Bijel Fibers for pH Responsive Composite Hydrogels

Kharal

Haase

2022

Small

View full text Add to dashboard Cite

helical microfibers are chiral, highly stretchable, and can be employed as micro-motors [7] and -swimmers. [8] However, current microfiber fabrication approaches offer limited control of the helical geometry.Microfluidic spinning technology (MST) has emerged as a tool to precisely tune the spatiotemporal chemical composition within microfibers. [9,10] MST employs a liquid precursor solution, which transforms into a semisolid fiber after flowing out of a microscopic orifice. Typical solidification mechanisms include ionic or chemical cross-linking, [11] photopolymerization, [12] and phase separation. [13] Helical fibers are formed in MST via the liquid rope coiling effect. [14,15] This hydrodynamic instability results in helices with large pitch lengths. [2] However, it remains difficult to combine multiple fibers into double, triple, or higher-order helices via liquid rope coiling. A better control of the helical multiplicity and shape can be realized upon actively rotating the microfibers. This has been shown for instance by Yasuda et al. in a planetary centrifuge. [16] But, these and other prevailing active fiber twisting methods are based on batch processing, limiting their technological potentials. [17,18] Recently, we have introduced microfluidic twisting (MT) to continuously generate composite helical fiber assemblies. [19] microfluidic twisting enables the combination of multiple helical fibers into high-order helices. The constituent fibers can have different sizes, twisting degrees, or chemical compositions. Although our prior work has explained the effect of the hydrodynamic forces controlling the helical pitch, the fundamental driving force of the helical assembly has not been elaborated. This knowledge gap has restricted the controlled collection of uniform helical fibers. Moreover, it has limited the choices of fiber precursor dispersions, resulting in strong, but inflexible helical fibers. [19] Here, we close this knowledge gap and show how centrifugal forces during microfluidic twisting enable the continuous assembly and collection of flexible, stimuli-responsive microropes. The assembly and collection of the microropes depends on the direction of the centrifugal force, which is determined by the density difference between the individual rope filaments and the surrounding fluid. The rope filaments in our work are composed of bicontinuous interfacially jammed emulsions gels (bijels) [20,21] formed via solvent transfer induced phase separation (STrIPS). [22][23][24][25] Bijels have potential applications as catalytic emulsions, [26] separation membranes, [23] battery components, [27,28] and sensors. [29] Interestingly, the density of the In microfluidics, centrifugal forces are important for centrifugal microfluidic chips and curved microchannels. Here, an unrecognized use of the centrifugal effect in microfluidics is introduced. The assembly of helical soft matter fibers in a rotating microcapillary is investigated. During assembly, the fibers undergo phase separation, generating particle stabilized...

show abstract

Fiber‐spinning Asymmetric Assembly for Janus‐structured Bifunctional Nanofiber Films towards All‐Weather Smart Textile

et al. 2022

Self Cite

View full text Add to dashboard Cite

Given health threat by global warming and increased energy consumption in regulating body temperature, it is an urgent need to construct smart temperature‐regulating materials. Herein, a novel fiber‐spinning asymmetric chemical assembly (FACA) method is proposed to construct nanofiber materials with asymmetric photothermal properties. The silver nanowires (AgNWs) and poly(vinylidene fluoride‐co‐hexafluoropropylene) (PVDF‐HFP) with opposite thermal radiation are assembled on reduced graphene oxide (rGO) film, imparting AgNW/rGO/PVDF‐HFP film with Janus structure that can realize the AgNWs side consistently keeps temperature of ca. 11 °C lower than the side of PVDF‐HFP nanofiber regardless of the irradiation directions under 1 sun, suggesting the adjustable photothermal regulation. Such photothermally selective hybrid nanofiber film provides great potential as fabrics to achieve all‐weather smart clothes, promoting controllable and comprehensive utilization of solar energy.

show abstract

A Phase Inversion‐Based Microfluidic Fabrication of Helical Microfibers towards Versatile Artificial Abdominal Skin

Cited by 5 publications

References 54 publications

Responsive hydrogel microfibers for biomedical engineering

Responsive hydrogel microfibers for biomedical engineering

Centrifugal Assembly of Helical Bijel Fibers for pH Responsive Composite Hydrogels

Fiber‐spinning Asymmetric Assembly for Janus‐structured Bifunctional Nanofiber Films towards All‐Weather Smart Textile

Contact Info

Product

Resources

About