A phenolic glycoside from Flacourtia indica induces heme mediated oxidative stress in Plasmodium falciparum and attenuates malaria pathogenesis in mice

An UPLC-Q-TOF/MS-Based Analysis of the Differential Composition of Dendrobium officinale in Different Regions

“…Phenolic glycosides, amides, and organic nitrogenous compounds were the main sign component of YN. Of these, phenolic glycosides are widely distributed in plants and are phenylalanine and tyrosine metabolites with antimalarial, antineuroinfammatory, antiobesity and antioxidant, and other activities, mainly [35][36][37][38]. It has lower biological activity compared to the corresponding glycosides, some of which may later be used as nutritional agents or adjuvants [35].…”

The acetone crude extract of Quercus infectoria (Olivier) galls alters pH of the digestive vacuole of the malaria parasite, Plasmodium falciparum

“…It is possible due to presence of the hydroxyl (-OH) group in the phenolic compounds as one of the features that has been linked to antimicrobial properties, including antimalarial properties (Kumar & Goel, 2019;Othman et al, 2019;Tajuddeen & Van Heerden, 2019). Phenolic glycosides isolated from Flacourtia indica commonly known as governor's plum have been shown to act through the inhibition of heme polymerization and β-hematin formation (Singh et al, 2017). The polyphenolic flavonoid, silymarin demonstrated antimalarial activity by forming soluble complexes with free heme, thereby blocking the formation of hemozoin (Mina et al, 2020).…”

Targeting virulence factors as an antimicrobial approach: Pigment inhibitors

“…Hydroxybenzyl alcohol ( 100 ), a phenolic glycoside isolated from the aerial parts of F. indica , was found to exhibit promising antiplasmodial activity by arresting P. falciparum growth at the trophozoite stage. Spectroscopic investigations revealed that 100 possessed a promising binding affinity with free heme moieties (IC 50 = 55.43 ± 6.78 µM) . Duan et al identified a series of novel carbazole amino alcohols ( 102 ) as potential antiplasmodial and antischistosomal agents and correlated the inhibitory activity of β‐hematin formation and antiparasitic activity through investigations on dual antiparasitic mechanisms .…”

“…Spectroscopic investigations revealed that 100 possessed a promising binding affinity with free heme moieties (IC 50 = 55.43 ± 6.78 µM). 214 Duan et al identified a series of novel carbazole amino alcohols (102) as potential antiplasmodial and antischistosomal agents and correlated the inhibitory activity of β-hematin formation and antiparasitic activity through investigations on dual antiparasitic mechanisms. 215 The xanthone derivatives were extracted from the sea urchin Strongylocentrotus purpuratus, and the identification of the antimalarial activity was serendipitous.…”