A Photo‐Responsive Hollow Manganese/Carbon Hybrid Nanosphere for Wound Disinfection and Healing

Abstract

The emergence of multi‐drug resistant (MDR) bacteria poses a serious threat to human health. It has become imperative to develop efficient antimicrobial strategies. Here, a manganese‐doped dopamine‐derived hollow carbon sphere (MnOx/HNCS) is developed as a nanozyme and photothermal agent for the synergistic treatment of MDR bacterial infections. MnOx/HNCS possesses oxidase, superoxide dismutase, and peroxidase like activities and implements self‐cascading enzymatic catalysis to produce superoxide anion (O2•−), hydrogen peroxide (H2O2), and hydroxyl radicals (•OH). Importantly, near‐infrared light facilitates the electron transport of MnOx/HNCS, allowing it to exhibit stable photothermal effects and photo‐enhanced enzymatic activity. Thereby MnOx/HNCS displays a broad‐spectrum synergistic antibacterial efficiency in vitro against six MDR pathogens based on the above photo‐regulated properties. In vivo experiments further demonstrate the excellent antibacterial efficiency of MnOx/HNCS in the MDR bacteria‐infected wound model. Notably, MnOx/HNCS not only has excellent disinfection capacity, but also can accelerate wound healing by stimulating the deposition of the extracellular matrix and reepithelialization. This study proposes a promising antibiotics‐alternative broad‐spectrum antibacterial strategy and paves a new avenue for the establishment of multifunctional photo‐responsive synergistic therapeutic platform.

Treatment of Acute Wound Infections by Degradable Polymer Nanoparticle with a Synergistic Photothermal and Chemodynamic Strategy

“…First, the synergistic factor Q values (see Supporting Information for computational formula and evaluation criterion) were calculated as 1.24 and 1.23 for P. aeruginosa and S. aureus , respectively. These two Q values were larger than 1.15 which was commonly used as a cutoff indicator of “strong synergy.” [ 23 ] Second, staining with live/dead double fluorescent dyes SYTO‐9/propidium iodide (PI) and imaging with confocal laser scanning microscopy (CLSM) were carried out and the results indicated that, for either P. aeruginosa or S. aureus (Figure 2g ), a few red fluorescences (dead) and abundant green fluorescence (live) were observed for bacterial cells treated with FF6, while abundant red fluorescence (dead) and a few green fluorescence (live) were observed for bacterial cells treated with FF4; by contrast, nearly all bacterial cells treated with FF8 gave red fluorescence (dead), further confirming the synergy.…”

A bismuth-based double-network hydrogel-mediated synergistic photothermal-chemodynamic therapy for accelerated wound healing

“…This, together with the complex manufacturing processes and inadequate photothermal conversion efficiency (Z), restricts further clinical translation. 30,31 Therefore, easy preparation of green PTT/CDT synergistic platforms with high Z and good biocompatibility remains an urgent issue to be addressed.…”

Antioxidase‐Like Nanobiocatalysts with Ultrafast and Reversible Redox‐Centers to Secure Stem Cells and Periodontal Tissues

“…[ 10–16 ] Nevertheless, most of the current studies on catalytic biotherapeutics focus on the synthesis, characterization, and biological applications of ROS‐production materials. [ 17–26 ] The developments of ROS‐scavenging biocatalysts are very slow and challenging. [ 27,28 ] Most reported antioxidase‐like reactive oxygen nanobiocatalysts (ROBCs) are based on metal oxides and metallic nanoparticles, [ 8,29–31 ] which usually exhibit low catalytic efficiencies and require high dosages.…”