A photo-triggered hydrogel for bidirectional regulation with imaging visualization

Ma, Teng; Sheng, Shupei; Dong, Xia; Zhang, Yan; Li, Xuemin; Zhu, Dunwan; Lv, Feng

doi:10.1039/d0sm01156h

Cited by 9 publications

(4 citation statements)

References 35 publications

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“…Several recent studies have focused their attention on changes in the external temperature that influence the responses of bacterial, cells, and tissues. Photothermal agents can convert light energy to heat under near infrared (NIR) irradiation [ 28 , 29 ]. The target temperature of photothermal hydrogels can be adjusted by changing the concentration and proportion of photothermal agents, irradiation time, and laser intensity [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

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Photothermal treatment (PTT) is a promising strategy to deal with multidrug-resistant bacteria infection and promote tissue regeneration. Previous studies demonstrated that hyperthermia can effectively inhibit the growth of bacteria, whereas mild heat can promote cell proliferation, further accelerating wound healing and bone regeneration. Especially, hydrogels with photothermal properties could achieve remotely controlled drug release. In this review, we introduce a photothermal agent hybrid in hydrogels for a photothermal effect. We also summarize the potential mechanisms of photothermal hydrogels regarding antibacterial action, angiogenesis, and osteogenesis. Furthermore, recent developments in photothermal hydrogels in wound healing and bone regeneration applications are introduced. Finally, future application of photothermal hydrogels is discussed. Hydrogels with photothermal effects provide a new direction for wound healing and bone regeneration, and this review will give a reference for the tissue engineering.

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Section: Introductionmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

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“…Preparation of a light-triggered hydrogel for bidirectional regulation based on IR820−α-cyclodextrin/PEGDA has been reported. 184 After the hydrogel is implanted in vivo, the softness and stiffness of the hydrogel can be adjusted bidirectionally by switching the irradiation wavelength. 184 In the future, biomaterials combining the properties of dynamic hydrogels and photo-cross-linked hydrogels are expected to be used in different biomedical fields for precise treatment.…”

Section: Dual Network Hydrogelsmentioning

confidence: 99%

“…Introducing dynamic hydrogels into photo-cross-linked materials may enable bidirectional intelligent control of photo-cross-linked hydrogels. Preparation of a light-triggered hydrogel for bidirectional regulation based on IR820−α-cyclodextrin/PEGDA has been reported . After the hydrogel is implanted in vivo, the softness and stiffness of the hydrogel can be adjusted bidirectionally by switching the irradiation wavelength .…”

Section: Future Perspectivesmentioning

confidence: 99%

Photo-cross-linked Hydrogels for Cartilage and Osteochondral Repair

Zhu,

Chen,

Liu

et al. 2023

ACS Biomater. Sci. Eng.

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Photo-cross-linked hydrogels, which respond to light and induce structural or morphological transitions, form a microenvironment that mimics the extracellular matrix of native tissue. In the last decades, photo-cross-linked hydrogels have been widely used in cartilage and osteochondral tissue engineering due to their good biocompatibility, ease of fabrication, rapid in situ gel-forming ability, and tunable mechanical and degradable properties. In this review, we systemically summarize the different types and physicochemical properties of photo-cross-linked hydrogels (including the materials and photoinitiators) and explore the biological properties modulated through the incorporation of additives, including cells, biomolecules, genes, and nanomaterials, into photo-cross-linked hydrogels. Subsequently, we compile the applications of photo-cross-linked hydrogels with a specific focus on cartilage and osteochondral repair. Finally, current limitations and future perspectives of photo-cross-linked hydrogels are also discussed.

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“…Recent studies have focused their attention on modifying the external temperature that influence the responses of bacteria, cells, and tissues [ 24 , 25 ]. By changing the concentration, irradiation time, and laser intensity of PTA, the target temperature of photothermal hydrogels can be modified.…”

Section: Introductionmentioning

confidence: 99%

Novel Photothermal Graphene-Based Hydrogels in Biomedical Applications

Croitoru,

Ficai,

Ficai

2024

Polymers

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In the last decade, photothermal therapy (PTT) has attracted tremendous attention because it is non-invasive, shows high efficiency and antibacterial activity, and minimizes drug side effects. Previous studies demonstrated that PTT can effectively inhibit the growth of bacteria and promotes cell proliferation, accelerating wound healing and tissue regeneration. Among different NIR-responsive biomaterials, graphene-based hydrogels with photothermal properties are considered as the best candidates for biomedical applications, due to their excellent properties. This review summarizes the current advances in the development of innovative graphene-based hydrogels for PTT-based biomedical applications. Also, the information about photothermal properties and the potential applications of graphene-based hydrogels in biomedical therapies are provided. These findings provide a great potential for supporting their applications in photothermal biomedicine.

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A photo-triggered hydrogel for bidirectional regulation with imaging visualization

Abstract: The bidirectional intelligent regulation of hydrogel is a critical challenge to the functional hydrogel on-demand. In this paper, a photo-triggered hydrogel for bidirectional regulation based on IR820-α-cyclodextrin/polyethylene glycol methyl acrylate...

Cited by 9 publications

References 35 publications

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Photo-cross-linked Hydrogels for Cartilage and Osteochondral Repair

Novel Photothermal Graphene-Based Hydrogels in Biomedical Applications

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