“…Solid MAs can deliver the drug in three approaches, including “poke and patch”, “coat and poke” and “poke and release” [ 1 , 2 , 28 , 29 ]. Solid MAs were fabricated by various methods, such as lithography and etching [ 30 ], photolithography [ 31 , 32 ], micro molding [ 33 , 34 ], drawing lithography [ 35 , 36 ], micromachining [ 34 ], laser cutting and so on. Solid MAs can be easily mass fabricated at a relatively low cost, but they have no continuity because they can support the delivery of a limited dose of drug, even in the case of “poke and patch” due to the fast closure of the poke pores in skin.…”