A photonic resonator interferometric scattering microscope for label-free detection of nanometer-scale objects with digital precision in point-of-use environments

Liu, Leyang; Tibbs, Joseph; Li, Nantao; Bacon, Amanda; Shepherd, Skye; Lee, Hankeun; Chauhan, Neha; Demirci, Utkan; Wang, Xing; Cunningham, Brian T.

doi:10.1016/j.bios.2023.115197

Cited by 8 publications

(3 citation statements)

References 53 publications

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“…No doubt, plasmonics and photonics offers the decisive spatial and temporal sovereignty on account of the capability of nanostructures to concentrate electromagnetic energy into nanoscale volumes [ 2 , 114 , 115 , 116 ]. A flurry of promising experiments using different types of AuNPs in various photo-plasmonic platform demonstrate a transformative impact on the way researchers engineer, manipulate, enhance and monitor the performance of biosensing approaches [ 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 ]. Here, we discuss the major challenges, and elucidate the future scope and opportunities.…”

Section: Limitations and Challengesmentioning

confidence: 99%

Review of Gold Nanoparticles in Surface Plasmon-Coupled Emission Technology: Effect of Shape, Hollow Nanostructures, Nano-Assembly, Metal–Dielectric and Heterometallic Nanohybrids

Ganesh,

Bhaskar,

Cheerala

et al. 2024

Nanomaterials

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Point-of-care (POC) diagnostic platforms are globally employed in modern smart technologies to detect events or changes in the analyte concentration and provide qualitative and quantitative information in biosensing. Surface plasmon-coupled emission (SPCE) technology has emerged as an effective POC diagnostic tool for developing robust biosensing frameworks. The simplicity, robustness and relevance of the technology has attracted researchers in physical, chemical and biological milieu on account of its unique attributes such as high specificity, sensitivity, low background noise, highly polarized, sharply directional, excellent spectral resolution capabilities. In the past decade, numerous nano-fabrication methods have been developed for augmenting the performance of the conventional SPCE technology. Among them the utility of plasmonic gold nanoparticles (AuNPs) has enabled the demonstration of plethora of reliable biosensing platforms. Here, we review the nano-engineering and biosensing applications of AuNPs based on the shape, hollow morphology, metal–dielectric, nano-assembly and heterometallic nanohybrids under optical as well as biosensing competencies. The current review emphasizes the recent past and evaluates the latest advancements in the field to comprehend the futuristic scope and perspectives of exploiting Au nano-antennas for plasmonic hotspot generation in SPCE technology.

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Section: Limitations and Challengesmentioning

confidence: 99%

Review of Gold Nanoparticles in Surface Plasmon-Coupled Emission Technology: Effect of Shape, Hollow Nanostructures, Nano-Assembly, Metal–Dielectric and Heterometallic Nanohybrids

Ganesh,

Bhaskar,

Cheerala

et al. 2024

Nanomaterials

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“…Plastics, being versatile and widely used, can often contain harmful chemicals that have been linked to adverse health effects, including hormone disruption, cancer, birth abnormalities, and developmental issues. It is intended to provide an advanced and highly sensitive sensor using PCL technology [37][38][39][40][41][42][43][44][45] to accurately detect and quantify the presence of these harmful chemical compounds within plastic products. This sensor aims to provide a reliable and efficient method for assessing the safety of plastic items, ranging from containers to children's toys, by rapidly identifying and measuring the concentration of hazardous substances.…”

Section: Introductionmentioning

confidence: 99%

Detection of Harmful Chemical Compounds in Plastic Products Using a High‐Sensitivity Photonic Crystal‐Based Sensor

Taya,

Srour,

Almawgani

et al. 2023

Physica Status Solidi (a)

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The use of plastics can be dangerous due to the numerous industrial chemicals they contain. Di(2‐ethylhexyl) phthalate (DEHP), bisphenol A (BPA), and bisphenol S (BPS) are three detrimental organic chemicals that are used in the plastic industry. In this work, a highly sensitive photonic crystal (PCL) sensor is theoretically proposed and numerically simulated as a detector for DEHP, BPA, and BPS organic chemicals. The proposed PCL is a 1D that has the structure (GaAs/Si3N4/TiN)N/cavity layer/(GaAs/Si3N4/TiN)N, where N is the number of unit cells (UCs). The DEHP, BPA, and BPS analytes are assumed to be separately infiltrated into the cavity layer between two equal numbers of the UCs. The transmission spectra of the PCL are studied using the transfer matrix (TrMx) technique. The most important performance parameter is sensitivity so we have focused on it. A considerable sensitivity enhancement is obtained by raising the defect layer thickness and incidence angle. High sensitivities of 2350.51, 2168.45, and 2042.08 nm RIU−1 are obtained for DEHP, BPA, and BPS, respectively. In the results obtained, the way can be paved for a simple technique to detect chemical compounds.

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“…The development of new, rapid and sensitive methods for point-of-need determination of environmental pollutants is an increasingly promising direction. The emergence of new compact devices expands the possibilities for their implementation [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Detection of Dibutyl Phthalate in Surface Water by Fluorescence Polarization Immunoassay

Mukhametova,

Karimova,

Zharikova

et al. 2023

Biosensors

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Dibutyl phthalate (DBP) is widely used as a plasticizer in the production of polymeric materials to give them flexibility, strength and extensibility. However, due to its negative impact on human health, in particular reproductive functions and fetal development, the content of DBP must be controlled in food and the environment. The present study aims to develop a sensitive, fast and simple fluorescence polarization immunoassay (FPIA) using monoclonal antibodies derived against DBP (MAb-DBP) for its detection in open waters. New conjugates of DBP with various fluorescein derivatives were obtained and characterized: 5-aminomethylfluorescein (AMF) and dichlorotriazinylaminofluorescein (DTAF). The advantages of using the DBP-AMF conjugate in the FPIA method are shown, the kinetics of binding of this chemical with antibodies are studied, the analysis is optimized, and the concentration of monoclonal antibodies is selected for sensitivity analysis—16 nM. The calibration dependence of the fluorescence polarization signal for the detection of DBP was obtained. The observed IC50 (DBP concentration at which a 50% decrease in the fluorescence polarization signal occurs, 40 ng/mL) and the limit of detection (LOD, 7.5 ng/mL) values were improved by a factor of 45 over the previously described FPIA using polyclonal antibodies. This technique was tested by the recovery method, and the high percentage of DBP discovery in water ranged from 85 to 110%. Using the developed method, real water samples from Lake Onega were tested, and a good correlation was shown between the results of the determination of DBP by the FPIA method and GC-MS. Thus, the FPIA method developed in this work can be used to determine DBP in open-water reservoirs.

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A photonic resonator interferometric scattering microscope for label-free detection of nanometer-scale objects with digital precision in point-of-use environments

Cited by 8 publications

References 53 publications

Review of Gold Nanoparticles in Surface Plasmon-Coupled Emission Technology: Effect of Shape, Hollow Nanostructures, Nano-Assembly, Metal–Dielectric and Heterometallic Nanohybrids

Review of Gold Nanoparticles in Surface Plasmon-Coupled Emission Technology: Effect of Shape, Hollow Nanostructures, Nano-Assembly, Metal–Dielectric and Heterometallic Nanohybrids

Detection of Harmful Chemical Compounds in Plastic Products Using a High‐Sensitivity Photonic Crystal‐Based Sensor

Detection of Dibutyl Phthalate in Surface Water by Fluorescence Polarization Immunoassay

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