A photothermal and self-induced Fenton dual-modal antibacterial platform for synergistic enhanced bacterial elimination

Xie, Xianghong; Wang, Rong; Zhang, Xi-Xi; Ren, Yarong; Du, Ting; Ni, Yongsheng; Yan, Huiling; Zhang, Liang; Sun, Jing; Zhang, Wentao; Wang, Jianlong

doi:10.1016/j.apcatb.2021.120315

Cited by 67 publications

(25 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 48 , 49 Xie et al proposed a synergistic antibacterial system based on copper peroxide-supported tungsten disulfide nanoflowers (CP@WS 2 NFs), which resulted in severe leakage of cellular components and reduced the amount of ATP and disrupted bacterial membranes. 50 …”

Section: Resultsmentioning

confidence: 99%

Ni Nanocrystals Supported on Graphene Oxide: Antibacterial Agents for Synergistic Treatment of Bacterial Infections

Huang

Cao

et al. 2022

ACS Omega

Self Cite

View full text Add to dashboard Cite

The effects of antibiotics on bacterial infections are gradually weakened, leading to the wide development of nanoparticle-based antibacterial agents with unique physical and chemical properties and antibacterial mechanisms different from antibiotics. In this study, we fabricated the uniform and stable graphene oxide (GO)/Ni colloidal nanocrystal cluster (NCNC) nanocomposite by electrostatic self-assembly and investigated its synergistic antibacterial activity against Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ) in vitro. The GO/NCNC nanocomposite was shown to possess higher inhibition efficiency than a pure NCNC or GO suspension, with 99.5 and 100% inhibition against S. aureus and E. coli at a 125 μg/mL concentration, respectively. Antibacterial mechanism analysis revealed that (i) NCNCs decorated on GO can further enhance the antibacterial properties of GO by binding and capturing bacteria, (ii) the leaching of Ni 2+ was detected during the interaction of GO/NCNCs and bacteria, resulting in a decrease in the number of bacteria, and (iii) the GO/NCNC nanocomposite can synergistically destroy the bacterial membrane through physical action and induce the reactive oxygen species generation, so as to further damage the cell membrane and affect ATPase, leakage of intercellular contents, and ultimately bacterial growth inhibition. Meanwhile, cell culture experiments demonstrated no adverse effect of GO/NCNCs on cell growth. These preliminary results indicate the high antibacterial efficiency of the GO/NCNC nanocomposite, suggesting the possibility to develop it into an effective antibacterial agent in the future against bacterial infections.

show abstract

Section: Resultsmentioning

confidence: 99%

Ni Nanocrystals Supported on Graphene Oxide: Antibacterial Agents for Synergistic Treatment of Bacterial Infections

Huang

Cao

et al. 2022

ACS Omega

Self Cite

View full text Add to dashboard Cite

show abstract

“…The light-to-heat transformation efficiency of the material was evaluated with reference to the literature. 33,34 For the photothermal stability test, the PEG-WO 3−x @EL NFs (200 µg mL −1 ) was performed for 3 cycles.…”

Section: Measurement Of Photothermal Performancementioning

confidence: 99%

A one-pot synthesis of PEGylated plasmonic WO_3−x@Eugenol nanoflowers with NIR-controllable antioxidant activities for synergetically combating bacterial biofilm infection

Xie

Zhang

Lei

et al. 2022

Inorg. Chem. Front.

Self Cite

View full text Add to dashboard Cite

show abstract

“…[37] In addition, another way to improve CDT efficacy is to provide exogenous H 2 O 2 for amplifying •OH generation. [22,[38][39][40] For example, Fenton-type metal peroxides have been reported as acidsensitive H 2 O 2 sources for enhanced CDT by self-producing H 2 O 2 . [38] Glucose oxidase and its mimics have been also employed as H 2 O 2 producers to achieve H 2 O 2 -self-supplied CDT.…”

Section: Introductionmentioning

confidence: 99%

“…[22,[38][39][40] For example, Fenton-type metal peroxides have been reported as acidsensitive H 2 O 2 sources for enhanced CDT by self-producing H 2 O 2 . [38] Glucose oxidase and its mimics have been also employed as H 2 O 2 producers to achieve H 2 O 2 -self-supplied CDT. [20,39,40] Despite tremendous efforts, there is a little study involving simultaneous regulation of GSH depletion and H 2 O 2 self-generation.…”

Section: Introductionmentioning

confidence: 99%

An Ultrasmall Fe₃O₄‐Decorated Polydopamine Hybrid Nanozyme Enables Continuous Conversion of Oxygen into Toxic Hydroxyl Radical via GSH‐Depleted Cascade Redox Reactions for Intensive Wound Disinfection

Xiao

Hai

et al. 2021

Small

View full text Add to dashboard Cite

Nanozyme‐based chemodynamic therapy (CDT) for fighting bacterial infections faces several major obstacles including low hydrogen peroxide (H2O2) level, over‐expressed glutathione (GSH) in infected sites, and inevitable damage to healthy tissue with abundant nonlocalized nanozymes. Herein, a smart ultrasmall Fe3O4‐decorated polydopamine (PDA/Fe3O4) hybrid nanozyme is demonstrated that continuously converts oxygen into highly toxic hydroxyl radical (•OH) via GSH‐depleted cascade redox reactions for CDT‐mediated bacterial elimination and intensive wound disinfection. In this system, photonic hyperthermia of PDA/Fe3O4 nanozymes can not only directly damage bacteria, but also improve the horseradish peroxidase‐like activity of Fe3O4 decorated for CDT. Surprisingly, through photothermal‐enhanced cascade catalytic reactions, PDA/Fe3O4 nanozymes can consume endogenous GSH for disrupting cellular redox homeostasis and simultaneously provide abundant H2O2 for improving •OH generation, ultimately enhancing the antibacterial performance of CDT. Such PDA/Fe3O4 can bind with bacterial cells, and reveals excellent antibacterial property against both Staphylococcus aureus and Escherichia coli. Most interestingly, PDA/Fe3O4 nanozymes can be strongly retained in infected sites by an external magnet for localized long‐term in vivo CDT and show minimal toxicity to healthy tissues and organs. This work presents an effective strategy to magnetically retain the therapeutic nanozymes in infected sites for highly efficient CDT with good biosafety.

show abstract

A photothermal and self-induced Fenton dual-modal antibacterial platform for synergistic enhanced bacterial elimination

Cited by 67 publications

References 40 publications

Ni Nanocrystals Supported on Graphene Oxide: Antibacterial Agents for Synergistic Treatment of Bacterial Infections

Ni Nanocrystals Supported on Graphene Oxide: Antibacterial Agents for Synergistic Treatment of Bacterial Infections

A one-pot synthesis of PEGylated plasmonic WO_3−x@Eugenol nanoflowers with NIR-controllable antioxidant activities for synergetically combating bacterial biofilm infection

An Ultrasmall Fe₃O₄‐Decorated Polydopamine Hybrid Nanozyme Enables Continuous Conversion of Oxygen into Toxic Hydroxyl Radical via GSH‐Depleted Cascade Redox Reactions for Intensive Wound Disinfection

Contact Info

Product

Resources

About

A photothermal and self-induced Fenton dual-modal antibacterial platform for synergistic enhanced bacterial elimination

Cited by 67 publications

References 40 publications

Ni Nanocrystals Supported on Graphene Oxide: Antibacterial Agents for Synergistic Treatment of Bacterial Infections

Ni Nanocrystals Supported on Graphene Oxide: Antibacterial Agents for Synergistic Treatment of Bacterial Infections

A one-pot synthesis of PEGylated plasmonic WO3−x@Eugenol nanoflowers with NIR-controllable antioxidant activities for synergetically combating bacterial biofilm infection

An Ultrasmall Fe3O4‐Decorated Polydopamine Hybrid Nanozyme Enables Continuous Conversion of Oxygen into Toxic Hydroxyl Radical via GSH‐Depleted Cascade Redox Reactions for Intensive Wound Disinfection

Contact Info

Product

Resources

About

A one-pot synthesis of PEGylated plasmonic WO_3−x@Eugenol nanoflowers with NIR-controllable antioxidant activities for synergetically combating bacterial biofilm infection

An Ultrasmall Fe₃O₄‐Decorated Polydopamine Hybrid Nanozyme Enables Continuous Conversion of Oxygen into Toxic Hydroxyl Radical via GSH‐Depleted Cascade Redox Reactions for Intensive Wound Disinfection