A phylogenetic study on the occurrence and distribution of histamine in the gastro-intestinal tract and other tissues of man and various animals

Lorenz, W.; Matejka, E.; Schmal, A.; Seidel, W; Reimann, H. J.; Uhlig, R.; Ge, Mann

doi:10.1016/0010-4035(73)90004-9

Cited by 85 publications

(34 citation statements)

References 58 publications

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“…[1959] for liver and kid neys; however, our values for heart and lungs deviate considerably from those of these au thors. With respect to the values in the heart, liver, kidneys and brain there is also rela tively good agreement with Lorenz et al [1973], whilst our values in the lungs are clearly lower and in the ileum somewhat higher. Finally we have not found any of the organ values, apart from those of the liver, to agree with those of Beall [1966],…”

Section: Basic Values Determined By This Methodssupporting

confidence: 72%

A Simplified Method for the Extraction and Isolation of Histamine from Whole Blood, Plasma and Tissues for Fluorometric Histamine Analysis

Sekardi

Friedberg

1982

Pharmacology

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A simplified method for the extraction and isolation of histamine from blood, plasma and freeze-dried tissue is described. Extraction is carried out with absolute or 80% ethanol. Subsequently histamine is isolated from an ion-exchange column and determined fluorometrically. The normal histamine contents of blood, plasma and various organs from guinea pigs are investigated by this procedure. The values obtained are compared with the data in the literature. On comparison of the histamine contents in the organs of guinea pigs of two weight and age classes, significant differences are found in the lungs, heart, spleen, kidneys and stomach. There seems to be an inverse relationship between body weight and histamine concentration.

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Section: Basic Values Determined By This Methodssupporting

confidence: 72%

A Simplified Method for the Extraction and Isolation of Histamine from Whole Blood, Plasma and Tissues for Fluorometric Histamine Analysis

Sekardi

Friedberg

1982

Pharmacology

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“…Histamine appears to act, at least in part, by increasing the production of prostaglandins which then stimulate the secretory process at the enterocyte. Although histamine is present in the intestinal tract (Lorenz et al 1973), it is not yet clear whether it plays a physiological role in the regulation of intestinal transport. However, in situations where local liberation of histamine leads to elevated intestinal levels, e.g.…”

Section: Effect Of Histamine On Fluid Transport In Vivomentioning

confidence: 99%

“…Histamine is present in the mucosa of the gastrointestinal tract (Lorenz, Matejka, Schmal, Seidel, Reimann, Uhlig & Mann, 1973) and is known to influence transport processes in both the stomach (Sachs & Berglindh, 1981) and the intestine (Lee & Silverberg, 1976;Linaker, McKay, Higgs & Turnberg, 1981; Cooke, Nemeth & Wood, 1984;McCabe & Smith, 1984). In the small intestine histamine induces a net secretion of fluid in vivo (Lee & Silverberg, 1976) but the underlying ionic basis of this effect appears to vary in different species, with an inhibition of Cl-absorption and HCO3-secretion being observed in rabbit ileum (Linaker et al 1981) while in guinea-pig ileum a stimulation of Cl-secretion was reported (Cooke et al 1984).…”

Section: Introductionmentioning

confidence: 99%

The secretory actions of histamine in rat small intestine.

Hardcastle

1987

The Journal of Physiology

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SUMMARY1. Histamine caused a dose-dependent rise in the transintestinal potential difference in vivo that was competitively blocked by H1, but not by H2 antagonists. This effect of histamine was also reduced by the cyclo-oxygenase inhibitor indomethacin.2. Histamine induced a net secretion of fluid by the small intestine and this effect was reduced by indomethacin.3, In intestinal sheets histamine increased the potential difference, short-circuit current and tissue resistance. This response was decreased in the absence of Cl-and in the presence of furosemide, suggesting that Cl-secretion was responsible for the observed electrical changes. This was confirmed by direct measurement of ion fluxes which showed an increase in net Cl-secretion together with an inhibition of net Na+ absorption.4. The response to histamine was Ca2+-dependent since it was inhibited by removal of serosal Ca2+ and by verapamil.5. Indomethacin caused a dose-dependent reduction in the response of intestinal sheets to histamine, without affecting the rise in short-circuit current induced by mucosal glucose or serosal prostaglandin E2. Mepacrine also inhibited the response to histamine, but not that to prostaglandin E2.6. It is concluded that histamine induces intestinal secretion by stimulating the production of prostaglandins which then activate the secretory process.

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“…The extracts were assayed (by Drs J. R. Simon and P. A. Shea) for 5-HT, noradrenaline, adrenaline and dopamine by high pressure liquid chromatography, as described by Loullis, Hingtgen, Shea & Aprison (1980), after precipitation of excess acid with K2 CO8. They were also assayed (by Professor W. Lorenz) for histamine, by fluorimetry following condensation of the histamine with orthophthaldialdehyde (Shore, Burkhalter & Cohn, 1959;Lorenz, Matejka, Schmal, Seidel, Reimann, Uhlig & Mann, 1973).…”

Section: Assay Of Aminesmentioning

confidence: 99%

Constrictor actions of acetylcholine, 5‐hydroxytryptamine and histamine on bovine coronary artery inner and outer muscle

Garland

Keatinge

1982

The Journal of Physiology

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SUMMARY1. In bovine coronary arteries, cholinesterase staining showed an extensive cholinergic innervation at the adventitia-media junction, and some cholinesterase in the outer but not inner smooth muscle.2. Acetylcholine or methacholine caused large, atropine-sensitive contractions of outer muscle but caused little contraction of inner muscle.3. Fluorescence microscopy for monoamines and for histamine, supported by chemical assays, showed no adrenergic innervation but showed numerous fluorescent cells in the adventitia and the outer 50 % of the media which stained as mast cells and contained large amounts of histamine and noradrenaline and some dopamine, but little 5-hydroxytryptamine (5-HT).4. 5-hydroxytryptamine (acting by D receptors) and histamine (acting by H1 receptors) in high concentrations caused large contractions, of similar size, in inner and outer muscle. In given submaximal concentrations they generally caused more contraction ofouter than inner muscle, particularly in the case of histamine, provided that imipramine or desipramine was present to inhibit uptake of the agents by mast cells which were present in the outer part of the artery wall.5. Without blockade of uptake, 5-HT applied to the arteries in submaximal concentrations caused less contraction of outer than inner muscle; histamine still caused significantly more contraction of outer than inner muscle.6. The findings indicate that the cholinergic constrictor nerves of these arteries, unlike adrenergic constrictor nerves of other systemic arteries, act almost solely on outer muscle of the vessel wall; and that mast cells give considerable protection against constriction by 5-HT, but little against histamine, reaching the vessel from its adventitial surface.

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A phylogenetic study on the occurrence and distribution of histamine in the gastro-intestinal tract and other tissues of man and various animals

Cited by 85 publications

References 58 publications

A Simplified Method for the Extraction and Isolation of Histamine from Whole Blood, Plasma and Tissues for Fluorometric Histamine Analysis

A Simplified Method for the Extraction and Isolation of Histamine from Whole Blood, Plasma and Tissues for Fluorometric Histamine Analysis

The secretory actions of histamine in rat small intestine.

Constrictor actions of acetylcholine, 5‐hydroxytryptamine and histamine on bovine coronary artery inner and outer muscle

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