This supplemental issue of Academic Medicine, prepared by the Bucksbaum Institute for Clinical Excellence at the University of Chicago, highlights the broad impact and complexity of the doctor-patient relationship.The Bucksbaum Institute for Clinical Excellence was established in September 2011 with a powerful, multipart mission to improve patient care, strengthen the doctor-patient relationship, enhance communication and shared decision making in health care, strengthen the personal and humanistic components of the doctor-patient relationship, and reduce health care disparities. The institute has worked to achieve its goals within the academic and patient communities at the University of Chicago. The institute has recognized numerous gifted physicians who act as role models and mentors. It has built programs to nurture the growth and development of current and future physicians at every level of training. The Bucksbaum Institute has also funded 162 pilot grants totaling almost $1.2 million to support initiatives that address all aspects of the doctor-patient relationship.