<p><strong>Abstract.</strong> Emission datasets of nitrogen oxides (NO<sub><i>x</i></sub>) at high horizontal resolutions (e.g., 0.05&#176;&#8201;&#215;&#8201;0.05&#176;) are crucial for understanding human influences at fine scales, air quality studies, and pollution control. Yet high-resolution emission data are often lacking or contain large uncertainties especially for the developing regions. Taking advantage of long-term satellite measurements of nitrogen dioxide (NO<sub>2</sub>), here we develop a computationally efficient method to inverting NO<sub><i>x</i></sub> emissions in major urban areas at the 0.05&#176;&#8201;&#215;&#8201;0.05&#176; resolution. The inversion accounts for the nonlinear effects of horizontal transport, chemical loss, and deposition. We construct a 2-dimensional Peking University High-resolution Lifetime-Emission-Transport (PHLET) model, its adjoint model (PHLET-A), and a Satellite Conversion Metrix approach to relate emissions, simulated NO<sub>2</sub>, and satellite NO<sub>2</sub> data. The inversion method is applied to summer months of 2012&#8211;2016 in the Yangtze River Delta area (YRD, 118&#8201;&#176;E&#8211;123&#8201;&#176;E, 29&#8201;&#176;N&#8211;34&#8201;&#176;N), a major polluted region of China, using the POMINO NO<sub>2</sub> vertical column density product retrieved from the Ozone Monitoring Instrument. A systematic analysis of inversion errors is performed, including using an Observing System Simulation Experiment-like test. Across the YRD area, the inverted summer average emission ranges from 0 to 12.0&#8201;kg&#8201;km<sup>&#8722;2</sup>&#8201;h<sup>&#8722;1</sup>, and the lifetime (due to chemical loss and deposition) from 1.4 to 3.6&#8201;h. Our inverted emission dataset reveals fine-scale spatial information tied to nighttime light, population density, road network, and maritime shipping. Many of the inverted fine-scale emission features are not well represented or not included in the widely used Multi-scale Emissions Inventory of China. Our inversion method can be applied to other regions and other satellite sensors such as the TROPOspheric Monitoring Instrument.</p>