1959
DOI: 10.1056/nejm195903192601204
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A Physiologic Approach to the Diagnosis of Acute Pulmonary Embolism

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Cited by 93 publications
(32 citation statements)
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“…This parameter corresponds closely to the V9E/V9CO 2 slope at the anaerobic threshold [12]. We found that in IPAH patients, EQCO 2 was inversely correlated with V9O 2 ,max.…”
Section: Discussionmentioning
confidence: 72%
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“…This parameter corresponds closely to the V9E/V9CO 2 slope at the anaerobic threshold [12]. We found that in IPAH patients, EQCO 2 was inversely correlated with V9O 2 ,max.…”
Section: Discussionmentioning
confidence: 72%
“…Ventilation was slightly increased in CTEPH at rest and during exercise (15 (4-21) versus 11 (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) and 58 (29-78) versus 50 (29-82) L?min -1 ), but with no significant difference between the two groups. There were no significant differences between CTEPH and IPAH in oxygen uptake upon maximal exercise (table 3), and tidal volume at rest and at maximal exercise (0.7 (0.4-1.3) versus 0.7 (0.5-1.4) and 1.9 (0.7-2.3) versus 1.9 (1.3-3.1) L, respectively).…”
Section: Discussionmentioning
confidence: 93%
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“…Dead space fraction (VD/VT), measured by comparing total exhaled CO 2 tension with arterial CO 2 tension, has previously been shown to be abnormal in PE and VD/VT in combination with D-dimer testing is effective at ruling out PE [11][12][13]21]. However, the requirement of specialised equipment and an arterial puncture limit its widespread adaptation.…”
Section: Clinical Practice Ar Hemnes Et Almentioning
confidence: 99%
“…unstable angina and gastrooesophageal reflux. Dead space measurement and arterial-alveolar CO 2 tension gradient have been studied in the evaluation of PE [11][12][13][14], but the utility of PET,CO 2 measurement alone in the diagnosis of PE is not known. PET,CO 2 is safe, noninvasive, inexpensive and rapidly performed at the bedside, whereas dead space measurement requires collection of exhaled gas and alveolar-arterial gradient requires arterial blood gas sampling.…”
mentioning
confidence: 99%