2014
DOI: 10.4149/gpb_2013060
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A physiological view and structures of mean residence times

Abstract: Abstract. The author's previous theoretical study described the determination of a physiologically realistic structure of a mean residence time of an intravenously administered drug (Ďurišová 2012). This study continues previous work and the aim is to determine physiologically realistic structures of mean residence times of a drug administered either orally (MRT po ) or intramuscularly (MRT im ). The determinations are based on the following assumption: a cardiopulmonary, portal, portal-venous, hepatic-portal … Show more

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Cited by 11 publications
(28 citation statements)
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“…They were used to model static and dynamic aspects of the pharmacokinetic behavior of digoxin [17][18][19] in the healthy male volunteers investigated in the previous study by Kramer et al [1] and in the current study. The method used in the current study has been described in detail in the previous studies [6][7][8][9][10][11][12][13][14][15][16], authored or co-authored by the author of the current study.…”
Section: Methodsmentioning
confidence: 99%
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“…They were used to model static and dynamic aspects of the pharmacokinetic behavior of digoxin [17][18][19] in the healthy male volunteers investigated in the previous study by Kramer et al [1] and in the current study. The method used in the current study has been described in detail in the previous studies [6][7][8][9][10][11][12][13][14][15][16], authored or co-authored by the author of the current study.…”
Section: Methodsmentioning
confidence: 99%
“…In the third step of the model development process, a transfer function, here denoted as H(S), of each pharmacokinetic dynamic system H was derived by relating the Laplace transform of the mathematical representation of the plasma concentration-time profile of digoxin, here denoted as C(S), and the Laplace transform of the mathematical representation of the intravenous input of digoxin into the body, here denoted as I(S), see Equation (1), (the lower case letter "S" denotes the complex Laplace variable), see e.g., the following studies [6][7][8][9][10][11][12][13][14][15][16] references therein.…”
Section: Methodsmentioning
confidence: 99%
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