2023
DOI: 10.1186/s13550-023-00958-7
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A physiologically based pharmacokinetic model for [68Ga]Ga-(HA-)DOTATATE to predict whole-body distribution and tumor sink effects in GEP-NET patients

Abstract: Background Little is known about parameters that have a relevant impact on (dis)similarities in biodistribution between various 68Ga-labeled somatostatin analogues. Additionally, the effect of tumor burden on organ uptake remains unclear. Therefore, the aim of this study was to describe and compare organ and tumor distribution of [68Ga]Ga-DOTATATE and [68Ga]Ga-HA-DOTATATE using a physiologically based pharmacokinetic (PBPK) model and to identify factors that might cause biodistribution and tumo… Show more

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Cited by 3 publications
(9 citation statements)
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“…1 . First, a population PK model of [ 68 Ga]Ga-HA-DOTATATE was developed fully informed by a previously developed PBPK model [ 26 ]. Subsequently, the model structure was applied to [ 177 Lu]Lu-HA-DOTATATE and parameters describing differences between both radiopharmaceuticals were estimated.…”
Section: Methodsmentioning
confidence: 99%
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“…1 . First, a population PK model of [ 68 Ga]Ga-HA-DOTATATE was developed fully informed by a previously developed PBPK model [ 26 ]. Subsequently, the model structure was applied to [ 177 Lu]Lu-HA-DOTATATE and parameters describing differences between both radiopharmaceuticals were estimated.…”
Section: Methodsmentioning
confidence: 99%
“…The first step of our approach was to develop a semi-physiological model for [ 68 Ga]Ga-HA-DOTATATE. Structural model development was informed based on a previously published PBPK model [ 26 ], where compartments were lumped based on their SSTR-expressing nature. This resulted in a six-compartment structural model, where compartments one to six represented the blood compartment, spleen, kidney, tumor lesions, other SSTR-expressing organs and a lumped rest compartment, respectively.…”
Section: Methodsmentioning
confidence: 99%
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