A Pilot Clinical Trial of Repetitive Transcranial Magnetic Stimulation in Mild Cognitive Impairment

Esmaeili, Sara; Abbasi, Mohammad Hossein; Malekdar, Ensieh; Joghataei, Mohammad Taghi; Mehrpour, Masoud

doi:10.14740/jnr622

J Neurol Res

2020

DOI: 10.14740/jnr622

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A Pilot Clinical Trial of Repetitive Transcranial Magnetic Stimulation in Mild Cognitive Impairment

Sara Esmaeili

Mohammad Hossein Abbasi

Ensieh Malekdar

et al.

Abstract: • rTMS applied over the left DLPFC improved MoCA scores in patients with MCI. • The effect of rTMS lasted up to 18-week follow-up. • rTMS was safe with no adverse effects.

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2024

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Efficacy and safety of transcranial magnetic stimulation on cognition in mild cognitive impairment, Alzheimer’s disease, Alzheimer’s disease-related dementias, and other cognitive disorders: a systematic review and meta-analysis

Pagali,

Kumar,

LeMahieu

et al. 2024

Int. Psychogeriatr.

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Objective: We aim to analyze the efficacy and safety of TMS on cognition in mild cognitive impairment (MCI), Alzheimer’s disease (AD), AD-related dementias, and nondementia conditions with comorbid cognitive impairment. Design: Systematic review, Meta-Analysis Setting: We searched MEDLINE, Embase, Cochrane database, APA PsycINFO, Web of Science, and Scopus from January 1, 2000, to February 9, 2023. Participants and interventions: RCTs, open-label, and case series studies reporting cognitive outcomes following TMS intervention were included. Measurement: Cognitive and safety outcomes were measured. Cochrane Risk of Bias for RCTs and MINORS (Methodological Index for Non-Randomized Studies) criteria were used to evaluate study quality. This study was registered with PROSPERO (CRD42022326423). Results: The systematic review included 143 studies (n = 5,800 participants) worldwide, encompassing 94 RCTs, 43 open-label prospective, 3 open-label retrospective, and 3 case series. The meta-analysis included 25 RCTs in MCI and AD. Collectively, these studies provide evidence of improved global and specific cognitive measures with TMS across diagnostic groups. Only 2 studies (among 143) reported 4 adverse events of seizures: 3 were deemed TMS unrelated and another resolved with coil repositioning. Meta-analysis showed large effect sizes on global cognition (Mini-Mental State Examination (SMD = 0.80 [0.26, 1.33], p = 0.003), Montreal Cognitive Assessment (SMD = 0.85 [0.26, 1.44], p = 0.005), Alzheimer’s Disease Assessment Scale–Cognitive Subscale (SMD = −0.96 [−1.32, −0.60], p < 0.001)) in MCI and AD, although with significant heterogeneity. Conclusion: The reviewed studies provide favorable evidence of improved cognition with TMS across all groups with cognitive impairment. TMS was safe and well tolerated with infrequent serious adverse events.

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Efficacy and safety of transcranial magnetic stimulation on cognition in mild cognitive impairment, Alzheimer’s disease, Alzheimer’s disease-related dementias, and other cognitive disorders: a systematic review and meta-analysis

Pagali,

Kumar,

LeMahieu

et al. 2024

Int. Psychogeriatr.

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show abstract

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A Pilot Clinical Trial of Repetitive Transcranial Magnetic Stimulation in Mild Cognitive Impairment

Abstract: • rTMS applied over the left DLPFC improved MoCA scores in patients with MCI. • The effect of rTMS lasted up to 18-week follow-up. • rTMS was safe with no adverse effects.

Cited by 1 publication

References 26 publications

Efficacy and safety of transcranial magnetic stimulation on cognition in mild cognitive impairment, Alzheimer’s disease, Alzheimer’s disease-related dementias, and other cognitive disorders: a systematic review and meta-analysis

Efficacy and safety of transcranial magnetic stimulation on cognition in mild cognitive impairment, Alzheimer’s disease, Alzheimer’s disease-related dementias, and other cognitive disorders: a systematic review and meta-analysis

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