A Pilot Comparative Study of 26 Biochemical Markers in Seminal Plasma and Serum in Infertile Men

Abstract

Introduction. The relationships of the biochemical components in seminal plasma and serum, and their origins and physiological effects in male reproductive system have been poorly understood. Methods. Based on the calibration and quality control measures, 26 biochemical markers, in seminal plasma and serum samples from 36 male infertility patients with nonazoospermia were detected and compared. Results. Only PA was undetectable in all seminal plasma samples. There were significant differences of all other 24 biochemical markers in seminal plasma and serum (P < 0.05) except for UA (P = 0.214). There were rich proteins in seminal plasma, and globulin accounted for about 90%. There were also abundant enzymes in seminal plasma, and the activities of ALT, AST, AKP, GGT, LDH, CK, and αHBDH in seminal plasma were significantly higher than those in serum while ADA was inversely lower. There were relatively low levels of Glu, TG, TC, and hsCRP in seminal plasma, but Glu was undetectable in 8 of 36 cases. Conclusions. The differences of the levels of biochemical markers in seminal plasma and serum might be associated with the selective secretion of testis, epididymis and male accessory glands, and the specific environment needed for sperm metabolism and function maintenance.

Impact of oxidative stress on semen parameters in normozoospermic infertile men: a case–control study

“…However, no significant difference in semen and serum glutathione level was found between the different groups. These results agree with previous reports by Guz et al [33] and Feng et al [34]; they reported no significant differences in semen and serum uric acid concentration between fertile and infertile men [33,34]. However, in a disagreement, Bhardwaj et al [35] reported a significant decrease in semen glutathione level in infertile men, and Thiele et al [14] reported significant decrease in uric acid concentration in normozoospermic infertile men comparing to fertile men.…”

Semen Biochemical Components in Varicocele, Leukocytospermia, and Idiopathic Infertility

“…Seminal plasma is the protein-rich fluid part of the semen and it plays an important role in sperm metabolism as well as sperm function. The analyses of seminal enzyme activities and the concentrations of biochemical elements have been performed in men and animals [1][2][3][4] in order to establish the functions of the different components, because some of them are still obscure.…”

Analyse des paramètres du spermogramme en relation avec le fructose, le citrate et l’alpha glucosidase neutre du sperme chez les hommes consultant pour infertilité à Libreville

“…La diminution du nombre de spermatozoïdes a trois principales causes. Les causes pré-testiculaires qui sont liées aux niveaux hormonaux sécrétés par l'hypophyse (Gordetsky et al, 2011). Les causes testiculaires qui sont liées à des lésions telles qu'une varicocèle (El Bardisi, 2018) et les causes post-testiculaires liées à une obstruction ou absence congénital des conduits déférents Ho et al (2015).…”

“…En effet, la composante masculine dans l'infertilité du couple a été estimée en Afrique subsaharienne à 20-40% . Pour ces hommes qui acceptent de consulter pour infertilité, en dehors du bilan hormonal, il est préconisé la réalisation d'une analyse de sperme, sous forme de spermogramme et spermocytogramme (Cooper et al, 2010 ;Esteves et al, 2012). Par ailleurs, une analyse biochimique du sperme peut également contribuer dans l'exploration de l'infertilité masculine (Feng et al, 2015).…”