A pilot genetic study of the continuum between compulsivity and impulsivity in females: The serotonin transporter promoter polymorphism

Baca‐García, Enrique; Salgado, Beatríz Rodríguez; Dolengevich-Segal, Helen; Lorenzo, C. Vaquero; Acosta, Mercedes Navío; Arrojo-Romero, Manuel; Hernandez, M.; Sáiz-Ruiz, Jerónimo; Piqueras, José Fernández; Leon, José de

doi:10.1016/j.pnpbp.2005.04.019

Cited by 53 publications

(26 citation statements)

References 31 publications

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“…Earlier studies linking 5-HTTLPR with impulsiveness have focused on special target groups, e.g., a higher prevalence of the S allele was found in impulsive suicide attempters (Baca-Garcia et al 2005) and in violent type 2 alcoholics (Hallikainen et al 1999). Our study was carried out on a population-based sample of adolescents.…”

Section: Discussionmentioning

confidence: 99%

Platelet MAO activity and the 5-HTT gene promoter polymorphism are associated with impulsivity and cognitive style in visual information processing

et al. 2007

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Section: Discussionmentioning

confidence: 99%

Platelet MAO activity and the 5-HTT gene promoter polymorphism are associated with impulsivity and cognitive style in visual information processing

et al. 2007

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“…A total of 18 manuscripts and 1 poster presentation published between 1997 and 2007 were included in this meta-analysis [Billett et al, 1997;McDougle et al, 1998;Ohara et al, 1998;Bengel et al, 1999;Frisch et al, 2000;Kinnear et al, 2000;Camarena et al, 2001;Di Bella et al, 2002;Chabane et al, 2004;Meira-Lima et al, 2004;Walitza et al, 2004;Baca-Garcia et al, 2005;Kim et al, 2005;Denys et al, 2006;Hu et al, 2006;Perez et al, 2006;Dickel et al, 2007;Lin, 2007;Miguita et al, 2007;Wendland et al, in press]. These manuscripts included 16 case-control studies including 1,797 OCD cases and 3,786 healthy controls and 6 familybased association studies including 486 trios cases.…”

Section: Description Of Studiesmentioning

confidence: 99%

“…The results of stratified meta-analysis by age became non-significant when either of the two studies involving children were removed from the analysis. The significant association between the l allele and OCD case status observed among Caucasians did not remain when the two studies failing to satisfy Hardy-Weinberg Equilibrium or when 8 of the 15 contributing studies were individually removed from the meta-analysis [McDougle et al, 1998;Bengel et al, 1999;Chabane et al, 2004;Meira-Lima et al, 2004;Baca-Garcia et al, 2005;Hu et al, 2006;Dickel et al, 2007]. The significant association between the l allele and OCD case status observed in family-based association studies did not remain when five of six of the contributing studies were removed [McDougle et al, 1998;Chabane et al, 2004;Walitza et al, 2004;Hu et al, 2006;Dickel et al, 2007].…”

mentioning

confidence: 99%

Association of the serotonin transporter polymorphism and obsessive‐compulsive disorder: Systematic review

Bloch

Landeros-Weisenberger

Sen

et al. 2008

American J of Med Genetics Pt B

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We investigated the association between the long (l) and short (s) alleles of the serotonin transporter polymorphism (5-HTTLPR) in the promoter region of the SLC6A4 gene and obsessive-compulsive disorder (OCD) using meta-analysis to combine all published data from case-control and family based association studies (2,283 cases). In stratified meta-analysis we investigated whether age of sample (child and adult), ethnicity (Caucasian and Asian) and study design (case-control and family-based association studies) moderated any association. In the overall meta-analysis we found no evidence of association between genetic variation at the 5-HTTLPR locus and OCD. We did find significant heterogeneity between studies. In the stratified meta-analyses, we demonstrated a significant association between the l-allele and OCD in family-based association studies and in studies involving children and Caucasians. Our meta-analysis suggests the possibility that the l-allele may be associated with OCD in specific OCD subgroups such as childhood-onset OCD and in Caucasians. Further meta-analyses based on individual patient data would be helpful in determining whether age of OCD onset, gender and the presence of comorbid illness (e.g., tics) moderates the relationship between 5-HTTLPR and OCD.

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“…An explanation for this discrepant data and the gender-specific effect might be that intermediate links between alcohol dependence and suicidal behaviour may involve different genetic factors in men and women. A recent study investigating the 5-HTTLPR in the continuum between compulsivity and impulsivity in females observed that the frequency of S-individuals (either homo-or heterozygotic) was low in patients with OCD, intermediate in non-impulsive controls and higher (82%) in impulsive suicide attempters 92 and thus it was suggested that genetic variants may be related more likely to behavioural dimensions instead of to specific psychiatric disorders.…”

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confidence: 99%

Genetics of suicide

2006

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The concept that genetic factors contribute to the complex trait of suicidal behaviour has stimulated much work aimed at identifying susceptibility genes. So far molecular genetic studies focused on the serotonergic pathway as the intent to die and the lethality of suicide acts were related to the serotonergic system. Two genes have so far emerged as being involved in the vulnerability for suicidality: first, the intronic polymorphisms (A218C or A779C) of the tryptophan hydroxylase 1 (TPH1) gene, which was suggested as a quantitative risk factor for suicidal behaviour; second, the insertion/deletion polymorphism of the serotonin transporter gene (5-HTTLPR), which does not seem to be involved in general suicidal behaviour, but in violent and repeated suicide attempts. The data have further shown that the MAOA gene, which is consistently associated with impulsive-aggressive personality traits, is not related to suicide but might induce violent methods in subjects with other suicide risk factors. Predominantly negative were the findings with any type of the serotonin receptors and inconsistent with catecholamine-synthesizing and -metabolizing enzymes or with the dopaminergic receptors. This paper reviews the status of current knowledge in this area, points to the weakness of the investigations and presents new approaches beyond the serotonergic system.

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A pilot genetic study of the continuum between compulsivity and impulsivity in females: The serotonin transporter promoter polymorphism

Cited by 53 publications

References 31 publications

Platelet MAO activity and the 5-HTT gene promoter polymorphism are associated with impulsivity and cognitive style in visual information processing

Platelet MAO activity and the 5-HTT gene promoter polymorphism are associated with impulsivity and cognitive style in visual information processing

Association of the serotonin transporter polymorphism and obsessive‐compulsive disorder: Systematic review

Genetics of suicide

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