A pilot investigation of accelerated deep transcranial magnetic stimulation protocols in treatment-resistant depression

Filipčić, Igor; Filipčić, Ivona Šimunović; Sučić, Strahimir; Milovac, Željko; Gereš, Natko; Matić, Katarina; Čelić-Ružić, Mirela; Penić, Sandra Zečević; Orgulan, Ivana; Požgaj, Vladimir; Bajić, Žarko

doi:10.1007/s00406-020-01141-y

Cited by 8 publications

(4 citation statements)

References 31 publications

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“…Still, all of these adverse effects were classified as being unrelated to the study device. Yesavage, et al (2018) [ 47 ] also reported cases of suicidal ideation in three active and four sham participants, though no suicides or seizures occurred during the study.…”

Section: Resultsmentioning

confidence: 99%

“…In most studies (n = 7), the stimulation was conducted with a Magstim Super Rapid stimulator system [ 42 , 43 , 44 , 45 , 46 , 47 , 48 ]. Four studies also applied the MagProX-100 or R30 stimulator [ 35 , 49 , 50 , 51 ].…”

Section: Resultsmentioning

confidence: 99%

“…The brain site for rTMS application employed by the studies ranged from the left PFC (n = 5) [ 42 , 46 , 49 , 50 , 53 ] to the left DLPFC (n = 4) [ 35 , 48 , 52 , 56 ]. Four studies indicated DLPFC without specifying either the left or right [ 45 , 47 , 51 , 55 ], with one study evaluating the difference in effectiveness between the left and right DLPFC [ 27 ]. Two of the remaining studies [ 43 , 44 ] assessed the effectiveness of left DLPFC against dorsomedial PFC, and one study evaluated the differences in effectiveness between unilateral and bilateral left DLPFC [ 54 ].…”

Section: Resultsmentioning

confidence: 99%

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Repetitive Transcranial Magnetic Stimulation for the Treatment of Resistant Depression: A Scoping Review

Adu

Shalaby

Chue

et al. 2022

Behavioral Sciences

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Treatment-resistant depression (TRD) is associated with significant disability, and due to its high prevalence, it results in a substantive socio-economic burden at a global level. TRD is the inability to accomplish and/or achieve remission after an adequate trial of antidepressant treatments. Studies comparing repetitive transcranial magnetic stimulation (rTMS) with electroconvulsive therapy (ECT) and pharmacotherapy have revealed evidence of the therapeutic efficacy of rTMS in TRD. These findings suggest a crucial role for rTMS in the management of TRD. This article aims to conduct a comprehensive scoping review of the current literature concerning the use of rTMS and its therapeutic efficacy as a treatment modality for TRD. PubMed, PsycINFO, Medline, Embase, and Cinahl were used to identify important articles on rTMS for TRD. The search strategy was limited to English articles within the last five years of data publication. Articles were included if they reported on a completed randomized controlled trial (RCT) of rTMS intervention for TRD. The exclusion criteria involved studies with rTMS for the treatment of conditions other than TRD, and study and experimental protocols of rTMS on TRD. In total, 17 studies were eligible for inclusion in this review. The search strategy spanned studies published in the last five years, to the date of the data search (14 February 2022). The regional breakdown of the extracted studies was North American (n = 9), European (n = 5), Asian (n = 2) and Australian (n = 1). The applied frequencies of rTMS ranged from 5 Hz to 50 Hz, with stimulation intensities ranging from 80% MT to 120% MT. Overall, 16 out of the 17 studies suggested that rTMS treatment was effective, safe and tolerated in TRD. For patients with TRD, rTMS appears to provide significant benefits through the reduction of depressive symptoms, and while there is progressive evidence in support of the same, more research is needed in order to define standardized protocols of rTMS application in terms of localization, frequency, intensity, and pulse parameters.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Repetitive Transcranial Magnetic Stimulation for the Treatment of Resistant Depression: A Scoping Review

Adu

Shalaby

Chue

et al. 2022

Behavioral Sciences

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“…Physical therapy is an effective treatment and usually shows antidepressant effects in the first week of treatment. [ 3 4 ] The combination of physical therapy and medicine may allow patients to take a shorter course of treatment and reduce the recurrence of MD during antidepressant treatment.…”

Section: Introductionmentioning

confidence: 99%

Left intermittent theta burst stimulation combined with right low-frequency rTMS as an additional treatment for major depression

Lou

et al. 2022

Indian Journal of Psychiatry

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Background: Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for major depression (MD). We retrospectively analyzed the efficacy of intermittent theta burst stimulation (iTBS) on the left dorsolateral prefrontal cortex (DLPFC) combined with low-frequency rTMS (LF-rTMS) on the right DLPFC as an additional therapy to standard medication treatment. Materials and Methods: The study included 54 patients with MD who completed 10 courses (5 days per week) of rTMS as an add-on therapy. Thirty patients were treated in the combination group (120% resting motor threshold; left DLPFC, iTBS, 600 stimuli + right DLPFC, 1-Hz rTMS, 600 stimuli), while 24 patients were in the high-frequency rTMS (HF-rTMS) group (120% resting motor threshold; left DLPFC, 10-Hz rTMS, 3000 stimuli). The outcome was assessed based on the changes in scores of 24-item Hamilton Depression Scale (HAMD-24) and 14-item Hamilton Anxiety Scale (HAMA-14). Results: Both depression and anxiety were significantly improved after 2 weeks of treatment by rTMS combined with medication. The combination of iTBS and LF-rTMS was significantly superior to HF-rTMS in improving the scores of HAMD-24 ( P = 0.041) and HAMA-14 ( P = 0.0095), and the response rate ( P = 0.027). Conclusion: The pilot study showed that the combination of iTBS and LF-rTMS may hold promise as a potentially effective alternative therapy for MD due to its efficacy and time-saving benefit. The preliminary results shed light on the study of the efficacy and acceptability of the combination of iTBS and LF-rTMS for MD.

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A transdiagnostic review of safety, efficacy, and parameter space in accelerated transcranial magnetic stimulation

Caulfield

Fleischmann²,

George³

et al. 2022

Journal of Psychiatric Research

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A pilot investigation of accelerated deep transcranial magnetic stimulation protocols in treatment-resistant depression

Cited by 8 publications

References 31 publications

Repetitive Transcranial Magnetic Stimulation for the Treatment of Resistant Depression: A Scoping Review

Repetitive Transcranial Magnetic Stimulation for the Treatment of Resistant Depression: A Scoping Review

Left intermittent theta burst stimulation combined with right low-frequency rTMS as an additional treatment for major depression

A transdiagnostic review of safety, efficacy, and parameter space in accelerated transcranial magnetic stimulation

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