Objective: To evaluate the effects of exposure to the School Oral Health Program (SOHP) during primary school years on the current oral health (OH) knowledge and practices and OH-related quality of life (OHRQoL) of Kuwait University students. Subjects and Methods: 300 university students, aged 17.6-24.3 years, completed avalidated questionnaire that consisted of 5 sections about demographics, health self-evaluation, OH knowledge and practices and OHRQoL. Of these students, 260 were female, 40 male, 262 single and 38 married. 189 participants had attended the SOHP, while 111 had not. Frequencies and means were used for data description. The Student t test was used to compare the means, while χ2 analysis was used for the associations between SOHP and non-SOHP attendance. The odds ratios (ORs) were calculated for significant factors. Results: The SOHP attendees were twice as aware of the relationship between gum problems and heart diseases than the non-SOHP (OR = 2, 95% CI = 1.15-3.48, p = 0.013). The daily activities of the non-SOHP attendees were twice as likely to be affected by dental health issues compared to those of the SOHP attendees (OR = 2.28, 95% CI = 1.41-3.68, p < 0.001). In addition, the SOHP attendees were 3 times as likely to describe their OH status as good/very good/excellent than the non-SOHP attendees (OR = 2.85, 95% CI = 1.31-6.18, p = 0.008). Conclusions: The SOHP attendees had a better OHRQoL and overall self-satisfaction with their OH than the non-SOHP attendees with insignificant differences between the 2 groups in OH knowledge and practices.