A Pilot, Open-Label Safety Study of Quetiapine for Treatment of Moderate Psychotic Agitation in the Emergency Setting

Currier, Glenn W.; Trenton, Adam; Walsh, Patrick; Wijngaarden, Edwin van

doi:10.1097/00131746-200607000-00004

Cited by 23 publications

(14 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since aripiprazole and olanzapine have been shown to be effective in monotherapy this should not be a frequent problem. In a small open-label study of quetiapine, orthostasis was present in 40% of patients at 100-200 mg doses (Currier 2006a).…”

Section: Safetymentioning

confidence: 99%

“…However, 93% of patients prefer oral formulations during a behavioural emergency, perceiving parenteral administration as coercive and abusive (Altamura 2003). Recent literature has shown that, for patients willing to take them, oral atypical antipsychotics are at least as effective as intramuscular typical antipsychotics in acute psychotic agitation (Currier 2006a). They should therefore be the first-line method of pharmacological administration (Mohr 2005).…”

Section: Pharmacological Interventions (Rapid Tranquillisation)mentioning

confidence: 99%

See 1 more Smart Citation

Management of acute agitation in psychosis: an evidence-based approach in the USA

Schleifer¹

2011

Adv. psychiatr. treat

View full text Add to dashboard Cite

SummaryAgitation in psychiatric settings, particularly in psychosis, presents a staggering challenge for clinicians, who must both manage the patient's acute symptoms and simultaneously make an accurate diagnosis. Too often, the management of the former confounds the latter. Patients are very often sedated medically, which masks their underlying condition, rendering accurate diagnosis delayed and inherently difficult. Significant data are available regarding both pharmacological and non-pharmacological interventions for agitation that maximise symptom control while minimising confounding side-effects. In this article, a review of the historical evolution of agitation management in psychotic illness is presented, followed by an evidence-based clinical guideline for managing agitation in psychosis in the USA.

show abstract

Section: Safetymentioning

confidence: 99%

Section: Pharmacological Interventions (Rapid Tranquillisation)mentioning

confidence: 99%

Management of acute agitation in psychosis: an evidence-based approach in the USA

Schleifer¹

2011

Adv. psychiatr. treat

View full text Add to dashboard Cite

show abstract

“…36 Second, research on quetiapine has indicated that while this medication is useful in inpatient settings, it has an unacceptably high risk of orthostatic hypotension in the emergency department where patients are often volume depleted. 41 Third, clozapine is only FDA approved for treatment-resistant schizophrenia and is not generally a first-line agent. Thus, although more study is needed, the use of aripiprazole, quetiapine, or clozapine cannot be recommended as first-line agents in the acute control of agitation.…”

Section: The Use Of Second-generation Antipsychoticsmentioning

confidence: 99%

The Psychopharmacology of Agitation: Consensus Statement of the American Association for Emergency Psychiatry Project BETA Psychopharmacology Workgroup

Wilson¹,

Pepper²,

Currier³

et al. 2012

WestJEM

344

264

View full text Add to dashboard Cite

Agitation is common in the medical and psychiatric emergency department, and appropriate management of agitation is a core competency for emergency clinicians. In this article, the authors review the use of a variety of first-generation antipsychotic drugs, second-generation antipsychotic drugs, and benzodiazepines for treatment of acute agitation, and propose specific guidelines for treatment of agitation associated with a variety of conditions, including acute intoxication, psychiatric illness, delirium, and multiple or idiopathic causes. Pharmacologic treatment of agitation should be based on an assessment of the most likely cause of the agitation. If agitation results from a delirium or other medical condition, clinicians should first attempt to treat the underlying cause instead of simply medicating with antipsychotics or benzodiazepines.

show abstract

“…Quetiapine, in particular, imposes an unacceptably high risk of orthostatic hypotension and so is not recommended for use in delirium in the emergency department. 27 Additionally, quetiapine is anticholinergic, raising concerns about constipation and urinary retention.…”

Section: Atypical Antipsychoticsmentioning

confidence: 99%

Delirium in hospitalized patients: Risks and benefits of antipsychotics

Thom

Mock

Teslyar

2017

CCJM

View full text Add to dashboard Cite

Consensus panel guidelines advocate for the judicious use of antipsychotic drugs to manage delirium in hospitalized patients when nonpharmacologic measures fail and the patient is in significant distress from symptoms, poses a safety risk to self or others, or is impeding essential aspects of his or her medical care. Here, we review the use of haloperidol, olanzapine, quetiapine, risperidone, and aripiprazole for this purpose.

show abstract

A Pilot, Open-Label Safety Study of Quetiapine for Treatment of Moderate Psychotic Agitation in the Emergency Setting

Cited by 23 publications

References 15 publications

Management of acute agitation in psychosis: an evidence-based approach in the USA

Management of acute agitation in psychosis: an evidence-based approach in the USA

The Psychopharmacology of Agitation: Consensus Statement of the American Association for Emergency Psychiatry Project BETA Psychopharmacology Workgroup

Delirium in hospitalized patients: Risks and benefits of antipsychotics

Contact Info

Product

Resources

About