A Pilot randomized clinical trial of adapted tango to improve cognition and psychosocial function in African American women with family history of Alzheimer's disease (ACT trial)

Wharton, Whitney; Jeong, Leanne; Ni, Liang; Bay, Allison A; Shin, Ryan; McCullough, Lauren E.; Silverstein, Hayley; Hart, Ariel R.; Swieboda, Dominika; Hu, William T.; Hackney, Madeleine E.

doi:10.1016/j.cccb.2021.100018

Cited by 5 publications

(4 citation statements)

References 75 publications

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“…Our results contrast with those of two recently published trials (Note: Wharton and colleagues results were an Alzheimer's Association published poster presentation with the clinical trial design published by Hackney et al, 2019) that did focus on middle aged/older African American adults (Hackney et al, 2019;Fausto et al, 2021;Wharton et al, 2021). These interventions utilized dance-based physical activity (i.e., cardio dance routines and adapted tango) and reported domainspecific cognitive improvements over time in the exercise condition in comparison to control.…”

Section: Discussioncontrasting

confidence: 94%

Exercise Effects on Cognition in Older African Americans: A Pilot Randomized Trial

Gwizdala

Brouillete

Beyl

et al. 2022

Front. Aging Neurosci.

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IntroductionRegular physical activity lowers risk for cognitive decline and neurodegenerative disorders. Older African Americans (AAs) have been underrepresented in trials that increased physical activity to improve cognitive outcomes.Methods56 sedentary, older, cognitively healthy AAs (avg. 69.2 ± 3.4 yrs. old) were randomized in 1:1 ratio into either a 12-week successful aging group (SAG) or a 12-week physical activity group (PAG). Participants in SAG attended weekly 60-min educational sessions in which healthy aging topics were discussed. Participants in PAG attended supervised physical activity sessions twice per week at local YMCAs (90–120 min/week) and were prescribed 2–3 days per week of home-based activity. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) assessed cognitive function. ANCOVA models compared mean 12-week change in global cognition and subdomain scores between groups with secondary analyses for sex differences. Effect sizes for RBANS were calculated.ResultsThe RBANS global cognition score (SAG Est. 5.6 ± 1.8, effect size = 0.37, p = 0.003) and several subdomain scores (one-sample T tests, all p < 0.05) increased significantly within the SAG. Scores for global cognition increased more in SAG than in PAG (Change Estimate, PAG minus SAG: –4.6 ± 2.5 points, effect size = 0.31) at a trend level (p = 0.072). SAG females increased their global cognition score more than PAG females and more than males in either PAG or SAG (all p < 0.035).DiscussionA 12-week physical activity intervention (PAG) did not improve cognitive functioning among older AAs but a comparator healthy aging education program did. Inadequate physical activity dosage or duration, SAG members acting on health-related information from educational sessions, and/or social stimulation within the SAG may have contributed to these results. Future studies should combine socially engaging activities with vigorous physical activity for cognitive enhancement among cognitively healthy older African Americans.Clinical Trial Registrationwww.ClinicalTrials.gov, identifier NCT03474302.

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Section: Discussioncontrasting

confidence: 94%

Exercise Effects on Cognition in Older African Americans: A Pilot Randomized Trial

Gwizdala

Brouillete

Beyl

et al. 2022

Front. Aging Neurosci.

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“… Sheppard et al. 36 Case-control study Washington, DC metro area N/A 52.42–57.63 years Walking for exercise and vigorous physical activity (running, aerobics, etc.) 2 h/week of vigorous physical activity was found to be protective against breast cancer in postmenopausal women.…”

Section: Resultsmentioning

confidence: 99%

Benefits and barriers to physical activity among African women: A systematic review

Obi

Nnonyelu

Onobrakpeya

et al. 2023

Sports Medicine and Health Science

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“…The partnered dance (dance) intervention consisted of partnered, Adapted, Argentine Tango dance (AdapTango) performed to traditional Argentine Tango music ( Hackney and McKee, 2014 ; Worthen-Chaudhari et al, 2019 ). This dance technique has been reported to improve balance, executive function, and biomarkers of inflammation for individuals with neurodegeneration including Parkinson Disease [citation] and prodromal AD ( Wharton et al, 2021 ). AdapTango was delivered via in-person instruction by a former professional dancer and certified medical exercise specialist (Worthen-Chaudhari) who was certified to teach AdapTango technique by its developer (Hackney).…”

Section: Methodsmentioning

confidence: 99%

“…Previously, we reported preliminary evidence that partnered Tango dance improved postural control among survivors with neuromotor deficits ( Worthen-Chaudhari et al, 2019 ). Outside of study in cancer populations, dance activity was reported to increase Brain-Derived Neurotropic Factor (BDNF), important for learning and memory in the aging brain ( Rehfeld et al, 2018 ), and decrease inflammatory biomarkers associated with Alzheimer’s Disease ( Wharton et al, 2021 ). While dance can be characterized as exercise when practice is planned, structured, repetitive, and performed intentionally for fitness goals (e.g., aerobic dance performed for cardiovascular fitness), we and others have defined dance as a form of physical activity than is distinguishable from conventional exercise ( Rehfeld et al, 2018 ; Worthen-Chaudhari et al, 2019 ; Blumen et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Partnered dance evokes greater intrinsic motivation than home exercise as therapeutic activity for chemotherapy-induced deficits: secondary results of a randomized, controlled clinical trial

Worthen-Chaudhari,

Schnell,

Hackney

et al. 2024

Front. Psychol.

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IntroductionDance has been proposed to support superior intrinsic motivation over non-dance forms of therapeutic physical activity. However, this hypothesis has yet to be evaluated empirically, particularly among populations living with neuropathology such as survivors of cancer with neurologic complications from chemotherapy treatment. Questions about motivation are relevant to clinical outcomes because motivation mediates neuroplasticity. We conducted this secondary analysis of a randomized-controlled study to begin to investigate the relationships between personal motivation and neurophysiologic effects of dance-based intervention for healthy aging among populations with neurologic complications of cancer.MethodsWe measured motivation using the Intrinsic Motivation Inventory, a validated patient-reported outcome from the psychological approach of Self Determination Theory. We assessed intrinsic motivation, extrinsic motivation, and satisfaction with intervention within a randomized controlled trial of dance versus exercise designed to alleviate symptoms of chemotherapy-induced impairment. Fifty-two survivors of breast cancer with chemotherapy-induced neuropathy diagnosis and associated sensorimotor functional deficits were randomized (1:1) to 8 weeks of partnered dance or home exercise, performed biweekly (NCT05114005; R21-AG068831).ResultsWhile satisfaction did not differ between interventions, intrinsic motivation was higher among participants randomized to dance than those randomized to exercise (p < 0.0001 at all timepoints: 2 weeks, 4 weeks, 6 weeks, and 8 weeks of intervention), as was extrinsic motivation at 2 weeks (p = 0.04) and 8 weeks (p = 0.01).DiscussionThese data provide evidence that social dance is more motivating than the type of home exercise generally recommended as therapeutic physical activity. The results inform directions for future study of the effect of dance-based therapeutics on embodied agency, neuroplastic changes, and clinically-relevant neuropathic improvement.

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A Pilot randomized clinical trial of adapted tango to improve cognition and psychosocial function in African American women with family history of Alzheimer's disease (ACT trial)

Cited by 5 publications

References 75 publications

Exercise Effects on Cognition in Older African Americans: A Pilot Randomized Trial

Exercise Effects on Cognition in Older African Americans: A Pilot Randomized Trial

Benefits and barriers to physical activity among African women: A systematic review

Partnered dance evokes greater intrinsic motivation than home exercise as therapeutic activity for chemotherapy-induced deficits: secondary results of a randomized, controlled clinical trial

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