Background: Despite decades of global tobacco control efforts, tobacco smoking remains a leading cause of preventable disease, death and inequality. Smoking is particularly common in people with mental health conditions. Smartphone apps have been developed as an accessible and affordable tool to support smokers with mental health conditions to quit smoking. However, limited data exists regarding the extent to which these apps are underpinned by evidence from research. Methods: We searched for apps designed to assist smokers with mental health conditions to quit smoking, in two ways: one, from the scientific literature, and two, directly from app stores. For the apps found in app store searches, we determined the extent to which they drew on theories or empirical research evidence for their design, their features, and claims of effectiveness. We assessed and compared usage and rating scores for all apps.Results: The literature search identified eight articles with five apps that were developed based on theories or empirical research evidence. Only two of these apps were available from an app store. Conversely, among the 22 apps found in the major app stores, only nine (41%) were built using theories or research evidence. All apps identified from app stores achieved far larger user numbers (minimum download rate = 1,000 times) and higher user rating scores (average 4.7 out of 5.0) than the apps identified in the literature search (user rating scores average 3.75). Conclusions: In general, smokers with mental health conditions are poorly served by available smoking cessation apps. Most apps developed using theories or empirical evidence are poorly used and have limited longevity. Researchers should plan for ongoing support of research-based apps, beyond the life of the research project. Developers should work in collaboration with researchers to build apps that combine theory and evidence with more engaging end-user design features.