A Pilot Study Assessing the Feasibility of a Short Period of Normothermic Preservation in an Experimental Model of Non Heart Beating Donor Kidneys

Normothermic <em>Ex Vivo</em> Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

“…In a porcine model, beneficial results were presented for kidneys perfused ex vivo under normothermic conditions 10,11 . The first clinical trial performed in 2013 demonstrated a lower rate of delayed graft function when kidneys retrieved from extended criteria donors were perfused for 1 hr immediately before transplant 12 .…”

A Biphasic Response to Nitric Oxide Donation in an Ex Vivo Model of Donation After Cardiac Death Renal Transplantation

“…As an alternative to prolonged ex vivo reperfusion, retrieval of kidneys from live donors followed by autotransplantation after the period of ex vivo perfusion allows assessment of the long-term impact of NO donation. The feasibility of this model has previously been demonstrated by our group [27]. Furthermore, an ex vivo reperfusion/autotransplant model could be compared with an in vivo reperfusion renal ischemia model to demonstrate potential benefits of ex vivo reperfusion and NO donation per se.…”

Machine perfusion viability testing

“…The Leicester group showed in a porcine kidney autotransplant model that after a period of 20 h of HMP, kidneys can be safely perfused with NMP for 2 h with autologous blood [42]. Thereafter, they perfused a human kidney with a warm solution of cross-matched packed red cells with crystalloids, nutrients and some medication, shortly before transplantation, which shows that short-term NMP is feasible in a clinical setting [43 & ].…”