A pilot study: comparative research of social functioning, circadian rhythm parameters, and cognitive function among institutional inpatients, and outpatients with chronic schizophrenia and healthy elderly people

Kume, Yu; Sugita, Takio; Oga, Kenya; Kagami, Kai; Igarashi, Hitomi

doi:10.1017/s1041610214001604

Cited by 9 publications

(11 citation statements)

References 29 publications

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“…Excluding 3 schizophrenia studies 36–38 with mean participant age >50 resulted in acrophase reaching statistical significance in this group (SMD [95% CI] = 0.47 [0.05, 0.89], P < .05), but did not alter outcomes for the other variables. Excluding the 2 bipolar disorder studies that included a subset of participants not meeting age 39 or remission criteria 58 did not significantly alter mean differences in sleep and circadian parameters, except for sleep efficiency in the bipolar disorder group no longer reaching statistical significance.…”

Section: Resultsmentioning

confidence: 94%

Sleep and Circadian Rhythm Disturbance in Remitted Schizophrenia and Bipolar Disorder: A Systematic Review and Meta-analysis

Meyer

Faulkner

McCutcheon

et al. 2020

Schizophrenia Bulletin

101

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Background Sleep and circadian rhythm disturbances in schizophrenia are common, but incompletely characterized. We aimed to describe and compare the magnitude and heterogeneity of sleep-circadian alterations in remitted schizophrenia and compare them with those in interepisode bipolar disorder. Methods EMBASE, Medline, and PsycINFO were searched for case–control studies reporting actigraphic parameters in remitted schizophrenia or bipolar disorder. Standardized and absolute mean differences between patients and controls were quantified using Hedges’ g, and patient–control differences in variability were quantified using the mean-scaled coefficient of variation ratio (CVR). A wald-type test compared effect sizes between disorders. Results Thirty studies reporting on 967 patients and 803 controls were included. Compared with controls, both schizophrenia and bipolar groups had significantly longer total sleep time (mean difference [minutes] [95% confidence interval {CI}] = 99.9 [66.8, 133.1] and 31.1 [19.3, 42.9], respectively), time in bed (mean difference = 77.8 [13.7, 142.0] and 50.3 [20.3, 80.3]), but also greater sleep latency (16.5 [6.1, 27.0] and 2.6 [0.5, 4.6]) and reduced motor activity (standardized mean difference [95% CI] = −0.86 [−1.22, −0.51] and −0.75 [−1.20, −0.29]). Effect sizes were significantly greater in schizophrenia compared with the bipolar disorder group for total sleep time, sleep latency, and wake after sleep onset. CVR was significantly elevated in both diagnoses for total sleep time, time in bed, and relative amplitude. Conclusions In both disorders, longer overall sleep duration, but also disturbed initiation, continuity, and reduced motor activity were found. Common, modifiable factors may be associated with these sleep-circadian phenotypes and advocate for further development of transdiagnostic interventions that target them.

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Section: Resultsmentioning

confidence: 94%

Sleep and Circadian Rhythm Disturbance in Remitted Schizophrenia and Bipolar Disorder: A Systematic Review and Meta-analysis

Meyer

Faulkner

McCutcheon

et al. 2020

Schizophrenia Bulletin

101

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“…Changes in circadian rhythms in patients with chronic schizophrenia can have a significant impact on their overall functioning and their ability to maintain adequate social lives. Among these changes is less exposure to daylight, which contributes to the reduced circadian rhythm synchronization (Kume et al, 2015). Wulff et al (2012) documented abnormalities in sleep-wake cycles and melatonin levels in patients with schizophrenia who had subjective sleep problems.…”

Section: Discussionmentioning

confidence: 99%

Circadian rest–activity rhythm in individuals at risk for psychosis and bipolar disorder

Castro

Zanini

Gonçalves

et al. 2015

Schizophrenia Research

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“…Another finding in this study is that comorbid CRSWD may be associated with psychosocial functioning. One study demonstrated no correlation between circadian rhythm and social dysfunction in patients with schizophrenia, but it focused on older adult patients and included both inpatients and outpatients [52]. To the best of our knowledge, our study is the first to focus on the relationship between CRSWD and psychosocial functioning in outpatients with schizophrenia across a wide age range.…”

Section: Discussionmentioning

confidence: 90%

Prevalence of Circadian Rhythm Sleep-Wake Disorder in Outpatients with Schizophrenia and Its Association with Psychopathological Characteristics and Psychosocial Functioning

Matsui

Inada

Kuriyama

et al. 2021

JCM

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The prevalence of circadian rhythm sleep-wake disorder (CRSWD) among patients with schizophrenia is not clear. The effect of comorbid CRSWD on such patients has also not been fully evaluated yet. Outpatients with schizophrenia in the maintenance phase who visited Tokyo Women’s Medical University Hospital between April 2018 and March 2019 participated in this study. The Brief Psychiatric Rating Scale (BPRS), the Clinical Global Impressions–Severity Illness Scale (CGI-S), Global Assessment of Functioning (GAF), World Health Organization Disability Assessment Schedule II, Insomnia Severity Index (ISI), and Morningness–Eveningness Questionnaire (MEQ) were administered, and the patient responses with and without CRSWD were compared. Of the 105 patients with schizophrenia, 19 (18.1%) had CRSWD. There were trends toward higher BPRS and lower GAF scores in the CRSWD group than in the non-CRSWD group, although these did not reach statistical significance following a false discovery rate correction. Among the BPRS subitems, the anxiety scores were significantly higher in the CRSWD group than in the non-CRSWD group (p < 0.01). CRSWD was highly prevalent among patients with schizophrenia in the maintenance phase. Comorbidities of CRSWD may affect psychopathological characteristics and psychosocial functioning.

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A pilot study: comparative research of social functioning, circadian rhythm parameters, and cognitive function among institutional inpatients, and outpatients with chronic schizophrenia and healthy elderly people

Cited by 9 publications

References 29 publications

Sleep and Circadian Rhythm Disturbance in Remitted Schizophrenia and Bipolar Disorder: A Systematic Review and Meta-analysis

Sleep and Circadian Rhythm Disturbance in Remitted Schizophrenia and Bipolar Disorder: A Systematic Review and Meta-analysis

Circadian rest–activity rhythm in individuals at risk for psychosis and bipolar disorder

Prevalence of Circadian Rhythm Sleep-Wake Disorder in Outpatients with Schizophrenia and Its Association with Psychopathological Characteristics and Psychosocial Functioning

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