A Pilot Study Examining Density of Suppression Measurement in Strabismus

Piano, Marianne; Newsham, David

doi:10.3109/09273972.2014.1002621

Cited by 26 publications

(22 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This test was difficult to administer (only seven of the children approached were able to perform it). Given the small sample size, and reports of poor test-retest reliability of this test, 50 we do not consider these data further.…”

Section: Orthoptic Assessmentmentioning

confidence: 99%

Binocular Therapy for Childhood Amblyopia Improves Vision Without Breaking Interocular Suppression

Bossi

Tailor

Anderson

et al. 2017

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

Section: Orthoptic Assessmentmentioning

confidence: 99%

Binocular Therapy for Childhood Amblyopia Improves Vision Without Breaking Interocular Suppression

Bossi

Tailor

Anderson

et al. 2017

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…Other studies have similarly reported limited test-retest reliability of the Flashlight W4D with NDF method. 12 Potentially the improved success rate and reliability with W4DApp is due to the continuous nature of the measures, which allow the contrast to be dropped in small numerical increments, whereas the Flashlight W4D is limited by the ordinal measures of the filter bar, with only 6 density intervals available. 10,11 Despite favorable success rate and reliability, the W4DApp measures of suppression depth were found to have no absolute agreement or significant correlation with the current clinical Flashlight W4D + NDF or the laboratory-based CBI techniques.…”

Section: Discussionmentioning

confidence: 99%

“…2 A 6-filter neutral density (NDF) bar (0.3-log-unit increments, range 0.3d-1.8d) 10 was used in combination with the flashlight to vary light intensity of the stimulus viewed by the dominant eye. 12 The relationship between NDF filter and light intensity was determined from 3 averaged luminance colorimeter readings of the light source through the range of filters.…”

Section: Flashlight W4dmentioning

confidence: 99%

“…Depth of suppression can be graded clinically by introducing a calibrated neutral density filter to lower the relative brightness of targets; however, limited testretest reliability is reported. [10][11][12] Recent studies have reported a significant correlation between the severity of suppression and the severity of amblyopia, despite these conditions being previously considered separate entities. 11,13 Furthermore, amblyopia treatment targeted at reducing suppression can significantly improve both binocular vision and monocular acuity.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Worth 4 Dot App for Determining Size and Depth of Suppression

Webber

Mandall

Molloy

et al. 2020

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

Citation: Webber AL, Mandall TR, Molloy DT, Lister LJ, Birch EE. Worth 4 Dot App for determining size and depth of suppression. Trans Vis Sci Tech. 2020;9(4):9, https://doi.org/10. 1167/tvst.9.4.9 Purpose: To describe and evaluate an iOS application suppression test, Worth 4 Dot App (W4DApp), which was designed and developed to assess size and depth of suppression.Methods: Characteristics of sensory fusion were evaluated in 25 participants (age 12-69 years) with normal (n = 6) and abnormal (n = 19) binocular vision. Suppression zone size and classification of fusion were determined by W4DApp and by flashlight Worth 4 Dot (W4D) responses from 33 cm to 6 m. Measures of suppression depth were compared between the W4DApp, the flashlight W4D with neutral density filter bar and the dichoptic letters contrast balance index test.Results: There was high agreement in classification of fusion between the W4DApp method and that derived from flashlight W4D responses from 33 cm to 6 m (α = 0.817). There were no significant differences in success rates or in reliability between the W4DApp or the flashlight W4D methods for determining suppression zone size. W4DApp suppression zone size strongly correlated to that determined with the flashlight W4D (rho = 0.964, P < 0.001). W4DApp depth of suppression measures showed significantly higher success rates (χ 2 = 5.128, P = 0.043) and reliability (intraclass correlation analysis = 0.901) but no significant correlation to the depth of suppression calculated by flashlight W4D and neutral density bar (rho = 0.301, P = 0.399) or contrast balance index (rho = −0.018, P = 0.958). Conclusions:The W4DApp has potential clinical benefit in measuring suppression zone size; however, further modifications are required to improve validity of suppression depth measures.Translational Relevance: W4DApp iOS application will be a convenient tool for clinical determination of suppression characteristics.

show abstract

“…However, we did not find robust changes of interocular suppression in our anisometropic amblyopes (8/10). Since both studies contain a small number of subjects, whether this is due to the individual variability or a poor test-retest reliability of the quantitative clinical test, even in adults (Piano and Newsham, 2015), remains to be resolved. Furthermore, a luminance-based interocular suppression test (i.e., the Sbisa bar test) in the study of Kehrein et al (2016) and a more quantitative laboratory, contrastbased interocular suppression test (i.e., the binocular phase combination task) in the current study might reflect different mechanisms that underlie interocular suppression .…”

Section: Discussionmentioning

confidence: 99%

Patching and Suppression in Amblyopia: One Mechanism or Two?

Chen

Mao

et al. 2020

Front. Neurosci.

View full text Add to dashboard Cite

Purpose: To determine if benefits from occlusion therapy are due to decreased suppression from the fellow eye in children with amblyopia.Methods: Ten newly diagnosed amblyopes (7.2 ± 1.4 years old), two with strabismus and eight with anisometropia, participated. Patients were first given a 2-month period of refractive adaptation, followed by occlusion therapy (i.e., patching their fellow eye with an opaque patch for 4 h/day). Visual acuity of the amblyopic eye and interocular suppression were measured before and after 0.5, 1, 2, 4, and 6 months of occlusion therapy. We quantified interocular suppression with a binocular phase combination task.Results: Visual acuity (in logMAR) improved from 0.50 ± 0.22 (mean ± SD) to 0.33 ± 0.20 for patients who finished a short-term (2 months) occlusion (A1-A10), from 0.53 ± 0.20 to 0.32 ± 0.22 for patients who finished a medium-term (4 months) occlusion (A1-A9), and from 0.48 ± 0.19 to 0.22 ± 0.10 for patients who finished a long-term (6 months) occlusion (A1-A8). Although their visual acuity significantly improved, their degree of suppression, which was abnormal in all cases, did not change consistently. This was true in all durations of occlusion therapy.Conclusion: Reduced suppression from the fixing eye might not be result from occlusion therapy.

show abstract

A Pilot Study Examining Density of Suppression Measurement in Strabismus

Cited by 26 publications

References 24 publications

Binocular Therapy for Childhood Amblyopia Improves Vision Without Breaking Interocular Suppression

Binocular Therapy for Childhood Amblyopia Improves Vision Without Breaking Interocular Suppression

Worth 4 Dot App for Determining Size and Depth of Suppression

Patching and Suppression in Amblyopia: One Mechanism or Two?

Contact Info

Product

Resources

About