A pilot study of acute phase proteins as indicators of bovine mastitis caused by different pathogens

Thomas, Funmilola Clara; Geraghty, Timothy; Simoes, Patricia; Mshelbwala, F. M.; Haining, Hayley; Eckersall, P.D.

doi:10.1016/j.rvsc.2018.06.015

Cited by 32 publications

(48 citation statements)

References 25 publications

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“…However, although the levels of both proteins increased during infection, the pattern of response was different when analyzing the different clinical stages and pathological forms of PTB. In most of the conditions evaluated in ruminants, the increase in the APPs’ levels was proportional to the severity of the lesions and clinical signs [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. In the case of mycobacterial diseases, studies carried out in tuberculous animals also showed increases in serum APPs according to the severity of the lesions present [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…The circulating concentration of these APPs is related to the severity of the disorder and the extent of tissue damage in the affected animal, therefore giving not only diagnostic but even prognostic value [ 17 ]. In this sense, the influence of different inflammatory conditions on the concentrations of these proteins in domestic livestock has been documented, such as in various bacterial and metabolic disorders such as metritis [ 18 ], mastitis [ 19 ], caseous lymphadenitis [ 20 ], respiratory infections [ 21 ], or ruminal acidosis [ 22 ]; parasitic diseases such as psoroptic and sarcoptic mange [ 23 , 24 ];or viral conditions as Schmallenberg virus infection [ 25 ], bovine viral diarrhea [ 26 ], blue tongue disease [ 27 ], or foot-and-mouth disease [ 28 ], among others.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Acute-Phase Protein Response Associated with the Different Pathological Forms of Bovine Paratuberculosis

Espinosa

Morena

Benavides

et al. 2020

Animals

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In this study, the concentrations of two acute-phase proteins (APPs), haptoglobin (Hp) and serum amyloid A (SAA), were quantitatively assessed in serum samples from cattle naturally infected with paratuberculosis (PTB). APP profiles were compared across 190 animals classified according to the different pathological forms associated with infection: uninfected (n = 59), with focal lesions (n = 73), multifocal lesions (n = 19), and diffuse paucibacillary (n = 11) and diffuse multibacillary lesions (n = 28). Our results showed a significant increase in both APPs in infected animals compared to the control group, with differences depending on the type of lesion. Hp and SAA levels were increased significantly in all infected animals, except in cows with diffuse multibacillary lesions that showed similar values to non-infected animals. The expression pattern of both APPs was similar and negatively correlated with the antibody levels against PTB. These results indicate that the release of Hp and SAA is related to the presence of PTB lesions associated with a high cell-mediated immune response and a lower bacterial load, suggesting that the pro-inflammatory cytokines that are associated with these forms are the main stimulus for their synthesis. These molecules could show some potential to be used as putative biomarkers of PTB infection, particularly for the identification of subclinical animals showing pathological forms related to latency or resistance to the development of advanced lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of Acute-Phase Protein Response Associated with the Different Pathological Forms of Bovine Paratuberculosis

Espinosa

Morena

Benavides

et al. 2020

Animals

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“…Expansion of the database with more species further improves the results (Nonnemann et al ., 2019). Identification of acute phase proteins as biomarkers in mastitis caused by different pathogens is also studied and promising results were obtained in a pilot study (Thomas et al ., 2018). Biosensor-based diagnostic methods based on plasmin protease as a biomarker coupled with a gold nanoparticle for the detection of mastitis pathogens are reported.…”

Section: Detection Methodsmentioning

confidence: 99%

Causes, types, etiological agents, prevalence, diagnosis, treatment, prevention, effects on human health and future aspects of bovine mastitis

Ashraf

Imran

2020

Anim. Health. Res. Rev.

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Mastitis is among the most common and challenging diseases of dairy animals. It is an inflammation of udder tissues due to physical damage, chemical irritation, or infection caused by certain pathogens. Bovine mastitis has been known for ages, but its complex etiology and multi-factorial nature make it difficult to control. Mastitis may have a negative impact on human health by inducing antibiotic-resistant pathogens that may spread, which is threatening. Researchers are continuously struggling to devise suitable methods for mastitis control. Management strategies are mainly focused on disease prevention by farm management which includes proper hygiene, trained staff to monitor minor changes in the udder or milk, and better diagnostic and treatment methods. New technologies which have the potential to unravel this complicated disease include improved diagnostic tools, based on advanced genomics or proteomics, prevention, based on vaccines and immune modulators, and metabolic products of probiotics such as bacteriocins and gene therapy.

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“…ELISA assay used for evaluating the levels of three different acute phase proteins (APP) in bovine milk namely: Haptoglobin, C-reactive protein and mammary associated serum amyloid A3. The etiological factor of mastitis greatly influences the pattern of APP in milk, for instance, E. coli, S. uberis and S. dysgalactiae mastitis showed higher values of APP in milk as compared to other pathogens (Thomasa et al, 2018).…”

Section: Whole Genome Sequencingmentioning

confidence: 99%

Comparative Diagnosis of Infectious Bacteria in Bovine Milk

Sedky¹,

Ghazy²,

Soliman³

et al. 2020

JAHP

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B ovine milk is a source of nutrition for people and calf since it contains the supplements necessary for growth and progress of the calf. It could be a source of lipids, proteins, amino acids, minerals and vitamins. It contains immunoglobulins, hormones, growth factors, cytokines, nucleotides and peptides (Haug et al., 2007). Raw bovine milk is considered as a suitable growth medium for the multiplication of nearly all kinds of microorganisms (Kumar et al., 2010; Mahmoud et al., 2019). Bovine milk is considered as a vehicle for many infectious bacterial diseases. The most common infectious bacterial diseases that spread via bovine milk to young calves and human are bovine tuberculosis, brucellosis, mycoplasma infection, leptospirosis, and Q fever.

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A pilot study of acute phase proteins as indicators of bovine mastitis caused by different pathogens

Cited by 32 publications

References 25 publications

Assessment of Acute-Phase Protein Response Associated with the Different Pathological Forms of Bovine Paratuberculosis

Assessment of Acute-Phase Protein Response Associated with the Different Pathological Forms of Bovine Paratuberculosis

Causes, types, etiological agents, prevalence, diagnosis, treatment, prevention, effects on human health and future aspects of bovine mastitis

Comparative Diagnosis of Infectious Bacteria in Bovine Milk

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