A Pilot Study of Blood Lead Levels and Neurobehavioral Function in Children Living in Chennai, India

Belliniger, David C.; Hu, Howard; Kalaniti, Kartigeyan; Thomas, Naveen; Rajan, Pradeep; Sambandam, Sankar; Padmavathi, R; Balakrishnan, Kalpania

doi:10.1179/oeh.2005.11.2.138

Cited by 33 publications

(21 citation statements)

References 17 publications

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“…Lead exposure is particularly concerning in developing countries where children have higher blood lead concentrations than in the US or Europe. 15–17 The present study examined the association between blood lead concentration (mean = 6.4 µg/dL) and behavioral problems using data from a community sample of Chinese preschool children.…”

Section: Introductionmentioning

confidence: 99%

Blood Lead Concentrations and Children’s Behavioral and Emotional Problems

et al. 2014

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Importance The association between lead exposure and children’s IQ has been well studied, but few studies have examined the effects of blood lead on children’s behavior. Objective This study examined the association between blood lead concentrations and behavioral problems in a community sample of Chinese preschool children with a mean blood lead level <10 µg/dL. Design Prospective cohort study. Setting Four elementary schools in Jintan City, Jiangsu Province of China. Participants Participants were 1341 children at ages 3–5 years. Main Outcome Measures Blood lead concentration was measured at ages 3–5 years. Behavioral problems were assessed using Chinese versions of the Child Behavior Checklist and Teacher Report Form when children at age 6 years. Results Mean blood lead concentration was 6.4 µg/dL (SD=2.6), with 75th and 90th percentiles being 7.7 and 9.4 µg/dL respectively. General linear modeling showed significant associations between blood lead concentrations and increased scores for teacher reported behavioral problems. One µg/dL increase of blood lead concentration resulted in a 0.32, 0.25 and 0.30 increase of behavior scores on emotional reactivity, anxiety/depressed and pervasive developmental problems, respectively (p <0.05), while adjusting for parental and child variables,. Spline modeling showed that teacher-reported behavior scores increased with blood lead concentration, particular for older girls. Conclusions and Relevance Blood lead concentrations, even at mean levels of 6.4 µg/dL, were associated with increased risk of behavioral problems in Chinese preschool children, including internalizing and pervasive developmental problems. This association showed different patterns depending on age and gender.

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Section: Introductionmentioning

confidence: 99%

Blood Lead Concentrations and Children’s Behavioral and Emotional Problems

et al. 2014

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“…This includes lowered intelligence, behavioral problems, deficits in academic achievements, and problem solving, as well as reductions in visual/spatial, motor, and language skills [1–3]. Thanks to public health and regulatory activities the BLL significantly decreased, however, still many studies have found adverse effects of levels below 10 μ g/dL.…”

Section: Introductionmentioning

confidence: 99%

Developmental Effects of Exposures to Environmental Factors: The Polish Mother and Child Cohort Study

Polańska

Hanke

Sobala

et al. 2013

BioMed Research International

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This paper estimates the effects of exposure to environmental factors, including lead, mercury, environmental tobacco smoke (ETS), and polycyclic aromatic hydrocarbons (PAH), on child psychomotor development. The study population consists of mother-child pairs in the Polish Mother and Child Cohort Study. Prenatal and postnatal exposure to environmental factors was determined from biomarker measurements as follows: for lead exposure—cord blood lead level, for mercury—maternal hair mercury level, for ETS—cotinine level in saliva and urine, and for PAH—1-hydroxypyrene (1-HP) in urine. At the age of 12 (406 subjects) and 24 months (198 subjects) children were assessed using Bayley Scales of Infant and Toddler Development. There were no statistically significant effects of prenatal exposure to mercury or 1-HP on child psychomotor development. After adjusting for potential confounders, adverse effects of prenatal exposure to ETS on motor development (β = −2.6; P = 0.02) and postnatal exposure to ETS on cognitive (β = −0.2; P = 0.05) and motor functions (β = −0.5; P = 0.01) were found. The adverse effect of prenatal lead exposure on cognitive score was of borderline significance (β = −6.2; P = 0.06). The study underscores the importance of policies and public health interventions that aim to reduce prenatal and postnatal exposure to lead and ETS.

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“…Recently, several clinical studies investigated the effects of low-level prenatal and perinatal lead exposure on intellectual development in children and found that mater-derived lead exposure would have a more powerful and lasting impact on neurobehavioral development of offspring than postnatal exposure [23-27]. Actually, even very low level of maternal blood lead (10 μg/dL) may induce intelligence quotient changes in the child [2].…”

Section: Introductionmentioning

confidence: 99%

Influences of different developmental periods of taurine supplements on synaptic plasticity in hippocampal CA1 area of rats following prenatal and perinatal lead exposure

Wang

et al. 2007

BMC Dev Biol

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Background: Previous study has demonstrated that dietary taurine supplement protected rats from impairments of synaptic plasticity induced by postnatal lead exposure. However, little is known about the role of taurine in the presence of prenatal and perinatal lead exposure. We investigated the possible effect of taurine supplement on prenatal and perinatal lead-induced synaptic plasticity deficit and determined developmental periods critical for the effect of taurine.

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A Pilot Study of Blood Lead Levels and Neurobehavioral Function in Children Living in Chennai, India

Cited by 33 publications

References 17 publications

Blood Lead Concentrations and Children’s Behavioral and Emotional Problems

Blood Lead Concentrations and Children’s Behavioral and Emotional Problems

Developmental Effects of Exposures to Environmental Factors: The Polish Mother and Child Cohort Study

Influences of different developmental periods of taurine supplements on synaptic plasticity in hippocampal CA1 area of rats following prenatal and perinatal lead exposure

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