A pilot study of HPV DNA and cytology testing in 50,159 women in the routine Mexican Social Security Program

Lazcano‐Ponce, Eduardo; Lörincz, Attila T.; Salmerón, Jorge; Fernández, Irma H.; Cruz, Aurelio; Hernández, Pilar; Mejía, I. Félix; Hernández-Ávila, Mauricio

doi:10.1007/s10552-010-9598-2

Cited by 36 publications

(29 citation statements)

References 39 publications

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“…This same pattern is seen in the Guanacaste cohort in Costa Rica [21] and in the previous Mexican study for HPV16, but not for HPV18 [11]. Overall, point estimates of HPV16/18 prevalence appear higher in other study populations throughout Latin America [9, 21, 23, 31], but due to different study designs, it is difficult to draw conclusions concerning the comparative burden of infections.…”

Section: Discussionsupporting

confidence: 70%

“…While cytology seems to be an obvious triage option given the existing infrastructure, we are also trying alternatives because of the difficulty of maintaining high-quality cytology in Mexico [9]. One potentially important option for the triage of hrHPV positive women would be to identify those positive for HPV16 and HPV18 for further evaluation and diagnostic confirmation.…”

Section: Introductionmentioning

confidence: 99%

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Population-based prevalence of cervical infection with human papillomavirus genotypes 16 and 18 and other high risk types in Tlaxcala, Mexico

et al. 2016

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BackgroundCervical cancer remains an important cause of cancer mortality for Mexican women. HPV 16/18 typing may help to improve cervical cancer screening. Here we present the prevalence of high-risk human papillomavirus (hrHPV) including HPV16 and HPV18 from the FRIDA (Forwarding Research for Improved Detection and Access) population.MethodsBeginning in 2013, we recruited 30,829 women aged 30–64 in Tlaxcala, Mexico. Cervical samples were collected and tested for 14 hrHPV genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68). We used logistic regression to estimate odds ratios with 95 % confidence intervals for hrHPV infections according to putative risk factors.ResultsPrevalence of infection with any of the 14 hrHPV types was 11.0 %. The age-specific prevalence of all hrHPV formed a U-shaped curve with a higher prevalence for women aged 30–39 and 50–64 than women aged 40–49. Across all age groups, 2.0 % of women were positive for HPV16 and/or HPV18 (HPV16/18), respectively. HPV16/18 prevalence also showed a U-shaped curve with increased prevalence estimates for women aged both 30–39 and 60–64. Both prevalence curves had a significant quadratic age coefficient. Infections with hrHPV were positively associated with an increased number of lifetime sexual partners, a history of sexually transmitted disease, being unmarried, use of hormonal contraception, having a history of smoking and reported condom use in the multivariate model.ConclusionsThe FRIDA population has a bimodal distribution of both hrHPV and HPV16/18 positivity with higher prevalences at ages 30–39 and 60–64. These findings will help to evaluate triage algorithms based on HPV genotyping.Trial registrationThe trial is registered with ClinicalTrials.gov, number NCT02510027.

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Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Population-based prevalence of cervical infection with human papillomavirus genotypes 16 and 18 and other high risk types in Tlaxcala, Mexico

et al. 2016

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“…18 Moreover, it was reported that PAP combined with HPV test increases the capability to identify cervical cancer 13,19,20 .…”

Section: Concurrent Infectionsmentioning

confidence: 99%

“…13 In this study, we determined HPV prevalence in 159,288 women in Michoacán State and HPV genotype in 45 samples from the Women's Hospital in Morelia, Michoacán.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Human Papillomavirus in Women from the State of Michoacan, Mexico, Showed High Frequency of Unusual Virus Genotypes

Jácome-Galarza¹,

Ito-Nakashimada

Figueroa-Aguilar

et al. 2017

RIC

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Background: Human papillomaviruses (HPVs), the leading cause of cervical cancer, are distributed worldwide, with high prevalence in developing countries. Objective: The objective of the study is to know the prevalence and genotypes of HPV in women from the state of Michoacán and the Women's Hospital in Morelia, Michoacán. Materials and Methods: Cervical smear samples (159,288) were subjected to HPV detection by hybrid capture 2. A subsample of 484 patients from the Women's Hospital was studied by Papanicolaou test and linear array HPV genotyping, and when positive, patients were also examined by colposcopy and histopathology. Results: The overall prevalence for HPV in Michoacán State was 7.74%; 7.11% in 2009, 6.46% in 2010, 9.58% in 2011, and 8.43% in 2012. The highest prevalence was found in the age groups < 25 and 25-34 years. The prevalence at the Women's Hospital was 8.51%. Cytological examination revealed normal cytology in 64.44% of samples, 26.66 % with low-grade and 8.88 % with high-grade squamous intraepithelial lesion (HSIL). However, by colposcopy, normal tissue appearance was found only in 26.66%; 51% were reclassified as low-grade squamous intraepithelial lesion, 17.77% as HSIL, and in 4.4% atrophy was observed. The most prevalent genotype in single infections was HPV59, followed by HPV51 and HPV45. Double infections occurred with the following genotypes:

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“…For the catch-up campaign for 14–15 year old boys the 3-dose coverage was assumed to be 72% equally split between 2013 and 2014. While the actual efficacy of the vaccine at preventing transmission is still unknown, we assumed the lower bounds of 80% for women [20,21] and 50% for men based on data from the clinical trials on efficacy against persistent infection [22]. The same trials showed that the efficacy could also be as high as 90% in women and 80% in men, but we consider the worst case scenario in this paper.…”

Section: Methodsmentioning

confidence: 99%

The potential impact of HPV-16 reactivation on prevalence in older Australians

Korostil

Regan

2014

BMC Infect Dis

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BackgroundSome regional cross-sectional human papillomavirus (HPV) DNA prevalence data show an increase in prevalence in older women, the reasons for which are as yet unknown. A recently published study suggests that the increase may be at least partly due to reactivation of latent HPV in menopausal women.MethodsWe developed a dynamic mathematical model of HPV-16 transmission to estimate the key consequences of hypothetical HPV-16 reactivation in the Australian heterosexual population. We only consider a worst case scenario with regard to reactivation in the Australian setting when all women who are latently infected reactivate and, wherever feasible, we choose model parameter values which may lead to a more pronounced reactivation. The ongoing National HPV vaccination program covering both women and men is incorporated in the model.ResultsWe estimate that about 1 in 10 women and men who appear to have cleared HPV-16 infection may be latently infected. The prevalence of HPV-16 in older Australian women will increase by a factor of up to 3.1 between now and 2025 which will be accompanied by an increase by a factor of around 1.9 in older men. However, the long-term impact of the HPV vaccination is not significantly altered by reactivation.ConclusionsIf the reactivation hypothesis we consider is substantiated, the public health response should be focused on further improvement of cervical screening coverage for older women. Our study also highlights the urgent need for surveillance of HPV prevalence in older Australians.

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A pilot study of HPV DNA and cytology testing in 50,159 women in the routine Mexican Social Security Program

Abstract: Population-based programs using HR-HPV testing can improve cervical cancer prevention and control in Mexican and other populations where cytological screening is inadequate for detecting precursors of cervical cancer.

Cited by 36 publications

References 39 publications

Population-based prevalence of cervical infection with human papillomavirus genotypes 16 and 18 and other high risk types in Tlaxcala, Mexico

Population-based prevalence of cervical infection with human papillomavirus genotypes 16 and 18 and other high risk types in Tlaxcala, Mexico

Prevalence of Human Papillomavirus in Women from the State of Michoacan, Mexico, Showed High Frequency of Unusual Virus Genotypes

The potential impact of HPV-16 reactivation on prevalence in older Australians

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