A Pilot Study of Intracavitary Hyperthermia Combined with Radiation in the Treatment of Oesophageal Carcinoma

Abstract

Twenty-five patients with primary squamous cell carcinoma of the oesophagus were treated with intracavitary hyperthermia combined with external beam radiation and intraluminal radiation at Nanjing Jinling Hospital, China. External beam radiation was given with a 6-MV X-ray; 1.8-2.0 Gy per fraction and five fractions per week; this brought the total dose to 60 Gy. Two weeks later, hyperthermia was applied with 915 MHz microwave intracavitary applicators, which were designed at the City of Hope. Temperature measurements were obtained while moving fibreoptic temperature sensors at 1.0 cm intervals in each of the six peripheral channels of the applicator. Hyperthermia was applied for 1 h before and after the intraluminal radiation. Intraluminal radiation was provided by low dose-rate iridium-192 ribbons in the same intracavitary applicator, giving 30 Gy at 0.75 cm from the applicator surface. The 3-month post-treatment responses showing complete response, partial response, no change and progressive disease were 60% (15/25), 24% (6/25), 8% (2/25) and 8% (2/25) respectively. The median follow-up time was 17 months (range 4-29 months). The 1- and 2-year overall survival rates were 72% (18/25) and 32% (8/25) respectively, and disease-free survival rates were 47 and 30% respectively. The median overall survival and disease-free survival periods were 17 and 10 months respectively. Fourteen patients had local recurrence (either at the primary site or in the lymph node) or had local progression, and five developed metastases. The median duration of the onset of local recurrence or of local progression was 9.5 months (range 0-20 months); the median of distant metastases was 8 months (range 2-16 months). Seventeen patients died. Of these, 15 died of cancer: six with local recurrence alone, four with local progression primary cancer alone, three with distant metastases alone, and two with both local and distant failure. Two patients with complete response of the primary disease died of other diseases. The toxicity was mild. According to the mucous reaction scoring criteria of the Radiation Therapy Oncology Group, the acute toxicity grades I, II, III and IV were 0% (0/25), 20% (5/25), 48% (12/25) and 32% (8/25) respectively. The major late complication was a mild oesophagus fibrosis and difficult swallowing. No serious side effects (grade IV), fistulas or perforations were seen. These results indicate that this method is safe and feasible for treating oesophageal carcinoma.

Late esophageal toxicity using a combination of external beam radiation, intraluminal brachytherapy and 5-fluorouracil infusion in carcinoma of the esophagus

“…Hishikawa et al 14 have reported a local control rate of 63% using external radiotherapy and brachytherapy. Mohanty et al 30 reported 44% local failures, whereas Ren et al 37 have reported 56% local failures in their series using external radiotherapy followed by ILRT and hyperthermia. Twenty patients (20%) developed local failure in our series within two treatment groups.…”

“…In our series, 16 patients (16%) developed strictures, with a significant correlation with dose of intraluminal brachytherapy. Ren et al 37 reported only mild esophageal fibrosis in one out of 25 patients treated using external beam radiation and intraluminal radiation in conjunction with hyperthermia.…”

Late esophageal toxicity using a combination of external beam radiation, intraluminal brachytherapy and 5-fluorouracil infusion in carcinoma of the esophagus

“…In our series, 16 patients (16%) developed strictures, with a signi®cant correlation with dose of intraluminal brachytherapy. Ren et al 37 reported only mild esophageal ®brosis in one out of 25 patients treated using external beam radiation and intraluminal radiation in conjunction with hyperthermia.…”

Biological Cell Survival Mapping for Radiofrequency Intracavitary Hyperthermia Combined with Simultaneous High Dose‐rate Intracavitary Irradiation

“…Intracavitary hyperthermia may be a better way to selectively heat the tumor than external hyperthermia. Various applicators and application techniques for the clinical application of intracavitary hyperthermia have been reported [19][20][21][22][23][24] and it was concluded that intracavitary hyperthermia could improve local control.…”