A pilot study of prophylactic ciprofloxacin during delayed intensification in children with acute lymphoblastic leukemia

Abstract

Compared to historical controls, patients in this study receiving prophylactic ciprofloxacin had a reduced rate and duration of hospitalization and incidence of Gram-negative bacteremia.

Clinical and Microbiologic Outcomes of Quinolone Prophylaxis in Children With Acute Myeloid Leukemia

“…However, only 2 RCTs and a pilot study have reported on the effect of antibiotic prophylaxis in children studying amoxicillin/clavulanate, 19 cefepime or vancomycin plus ciprofloxacin 9 and ciprofloxacin alone. 20 FN was common in our cohort, occurring in 88% of CCs. Although we excluded febrile episodes that coincided with cytarabine infusion and were thought to not be infectious, its contribution to the overall prevalence of fever in this cohort cannot be fully excluded.…”

Prophylactic First-Line Antibiotics Reduce Infectious Fever and Shorten Hospital Stay during Chemotherapy-Induced Agranulocytosis in Childhood Acute Myeloid Leukemia

“…In particular, these patients did not receive any stimulating factors, but no significant difference was found between the prophylactic and control groups [18]. One self-controlled study demonstrated that preventive use of ciprofloxacin during the induction stage in 69 pediatric patients with acute lymphatic leukemia effectively reduced the infection rate of Gram-negative bacteria [22] compared with the control group. At the early stage of this study, we used vancomycin plus cefepime for the treatment.…”

Prophylactic levofloxacin in pediatric neutropenic patients during autologous hematopoietic stem cell transplantation

“…A retrospective study in pediatric cancer patients undergoing HSCT both autologous and allogenic showed no difference in febrile episodes with fluoroquinolone prophylaxis than without, but there was significantly lower bacteremia in the prophylaxis group . A pilot study of ciprofloxacin prophylaxis for pediatric patients receiving delayed intensification therapy for acute lymphoblastic leukemia showed a significant reduction in hospitalization, intensive care admission, and bacteremia compared to historical controls . In another study in acute myeloid leukemia pediatric patients, the only benefit of fluoroquinolone prophylaxis was the reduction in gram‐negative bacteremia .…”