A pilot study of proximal strength training in Charcot‐Marie‐Tooth disease

Ramdharry, Gita; Pollard, Alexander J.; Anderson, Cheryl A.M.; Laurá, Matilde; Murphy, Sinéad M.; Dudziec, M; Dewar, E; Hutton, Elspeth; Grant, Robert; Reilly, Mary M.

doi:10.1111/jns.12100

Cited by 29 publications

(60 citation statements)

References 19 publications

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“…21 Only three randomized controlled trials were found. 9 Also in our cohort of ICU-acquired weakness, resistance training appears to be less effective to improve walking, when compared to cycle ergometer training. 9 Also in our cohort of ICU-acquired weakness, resistance training appears to be less effective to improve walking, when compared to cycle ergometer training.…”

Section: Idence-based Overview Of the Effectiveness Of Various Intervmentioning

confidence: 61%

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Cycle ergometer training vs resistance training in ICU‐acquired weakness

et al. 2019

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Objectives We investigated the effectiveness of cycle ergometer training and resistance training to enhance the efficiency of standard care to improve walking ability, muscular strength of the lower limbs, cardiovascular endurance and health‐related quality of life during inpatient rehabilitation in intensive care unit acquired weakness. Materials & methods Thirty‐nine patients with severe to moderate walking disability were enrolled in one of the three experimental groups: (a) ergometer training group, (b) resistance training group and (c) control group (standard care only). Intervention was applied 5 days a week over a 4‐week period during inpatient neurological rehabilitation. We evaluated walking ability (Functional Ambulation Category test, timed up and go test, 10‐metre walk test and 6‐minute walk test), muscle strength (Medical Research Council and maximum muscle strength tests), cardiovascular endurance and muscular endurance of the lower limbs at the fatigue threshold (physical working capacity at fatigue threshold) and quality of life (medical outcomes study SF‐36 form). All tests were performed at baseline, after two weeks of treatment and at the end of the 4‐week intervention period. Results Ergometer training and resistance training enhanced the effectiveness of standard care in order to improve (a) lower limb muscle strength, (b) walking ability and (c) cardiorespiratory fitness during inpatient rehabilitation of intensive care acquired weakness. In addition, ergometer training may be superior to resistance training. Conclusions Our data encourage more research to develop and implement these training tools in rehabilitation programmes for intensive care acquired weakness.

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Section: Idence-based Overview Of the Effectiveness Of Various Intervmentioning

confidence: 61%

“…[8][9][10] During resistance training, interrupted activity at high intensity (level 16 on the Borg scale 7 ) was performed over a total of 20 minutes. A medical wheelchair ergometer training apparatus (MOTOmed, Reck, Betzenweiler, Germany) was used.…”

Section: Interventionmentioning

confidence: 99%

Cycle ergometer training vs resistance training in ICU‐acquired weakness

et al. 2019

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“…[12] Physical activity data collection took place during the control phase of the exercise trial, where participants were asked to continue with their normal routine and activities. Participants were included if they were aged 18–70 years, had a clinical diagnosis of CMT, or related condition, and were able to walk 50 meters with or without an aid.…”

Section: Methodsmentioning

confidence: 99%

A study of physical activity comparing people with Charcot-Marie-Tooth disease to normal control subjects

Ramdharry

Pollard

Grant

et al. 2016

Disability and Rehabilitation

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Purpose Charcot Marie Tooth disease (CMT) describes a group of hereditary neuropathies that present with distal weakness, wasting and sensory loss. Small studies indicate that people with CMT have reduced daily activity levels. This raises concerns as physical inactivity increases the risk of a range of co- morbidities, an important consideration in the long-term management of this disease. This study aimed to compare physical activity, patterns of sedentary behavior and overall energy expenditure of people with CMT and healthy matched controls. Methods We compared 20 people with CMT and 20 matched controls in a comparison of physical activity measurement over seven days, using an activity monitor. Patterns of sedentary behavior were explored through a power law analysis. Results Results showed a decrease in daily steps taken in the CMT group, but somewhat paradoxically, they demonstrate shorter bouts of sedentary activity and more frequent transitions from sedentary to active behaviors. No differences were seen in energy expenditure or time spent in sedentary, moderate or vigorous activity. Conclusion The discrepancy between energy expenditure and number of steps could be due to higher energy requirements for walking, but also may be due to an over-estimation of energy expenditure by the activity monitor in the presence of muscle wasting. Alternatively, this finding may indicate that people with CMT engage more in activities or movement not related to walking.

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“…11,12 Despite the verisimilitude of the objectives, a wide range of methods were used to measure the outcome of the evidence: muscular strength, the only common measurement, was evaluated through different methods (QMA, 1RM, myometre), so it does not allow any comparison.As for the results, all evidence points to the effectiveness of physiotherapy in CMT, as it is associated with an increase of the strength. 11–14 The muscles involved are different in different trials: the muscles of the arm, 11 the pelvic girdle and thigh (hip flexors and quadriceps), 12–14 and the knee.…”

Section: Discussionmentioning

confidence: 99%

Rehabilitation Management of the Charcot–Marie–Tooth Syndrome

2016

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The Charcot–Marie–Tooth disease (CMT) causes significant muscular deficits in the affected patients, restricts daily activities (ADL), and involves a severe disability. Although the conservative intervention is the only treatment for the disease, there is no scientific evidence so far on rehabilitation treatment. Objectives of the review are: research the best literary evidence so far on the rehabilitation treatment of CMT; critically analyze the outcome, to build an evidence-based work protocol.A systematic review of the rehabilitation of a patient with CMT, including the results from the following databases: Pubmed, Medline, Embase, Pedro, Cinahl, Ebsco discovery. Criteria for inclusion: randomized/controlled studies, analytic studies, transversal studies on a cohort of at least 10 individuals; medium/long-term report of the results.Eleven studies in total have been admitted to the final review phase; trials about physiotherapy CMT treatment (5), about orthosis treatment (6). Despite the wide range of outcomes and proposed interventions, the data points to the following: strength or endurance trainings improve functionality and ADLs of affected patients, while orthotic role is, at the moment, not completely clear.Physiotherapy treatment is a useful tool to manage CMT; more studies on a larger number of cases are needed to define orthosis utility and to establish the gold standard of the treatment.

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A pilot study of proximal strength training in Charcot‐Marie‐Tooth disease

Cited by 29 publications

References 19 publications

Cycle ergometer training vs resistance training in ICU‐acquired weakness

Cycle ergometer training vs resistance training in ICU‐acquired weakness

A study of physical activity comparing people with Charcot-Marie-Tooth disease to normal control subjects

Rehabilitation Management of the Charcot–Marie–Tooth Syndrome

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