A pilot study of silver-loaded cellulose fabric with incorporated seaweed for the treatment of atopic dermatitis

Abstract

Summary Because clothing has the longest and most direct contact with human skin, it is important to carefully choose suitable fabrics for atopic patients who have disrupted skin. To evaluate the clinical effectiveness and biophysical properties of a newly developed silver‐loaded cellulose fabric with incorporated seaweed, we enrolled 12 subjects with mild to moderate atopic dermatitis into a clinical control study. The subjects wore a two‐piece garment (top and leggings), each piece of which was divided into two parts: one side was made of SkinDoctor® fabric, and the other of 100% cotton. Treatment efficacy was measured with the modified SCORing Atopic Dermatitis (mSCORAD) index, transepidermal water loss (TEWL) and the patients’ subjective impressions. All three of these measures had significantly better scores on the side covered with SkinDoctor. These results suggest that SkinDoctor is a beneficial fabric that can improve the comfort of patients with AD.

Randomised controlled trial of silk therapeutic garments for the management of atopic eczema in children: the CLOTHES trial

“…10,11 To identify RCTs published prior to the CLOTHES trial, we searched the Global Resource of Eczema Trials database. 12 At the time of starting the CLOTHES trial, 14 small RCTs assessing the effects of therapeutic clothing had been published: three RCTs investigated silk clothing [DermaSilk TM (AlPreTec Srl, San Donà di Piave, Italy)]; [13][14][15] two investigated silver-coated textiles; 16,17 three investigated cellulose seaweed fibres with silver; [18][19][20] one investigated cellulose; 21 one investigated an anion textile; 22 two investigated types of ethylene vinyl alcohol fibre; 23,24 one investigated borage oil-coated garments; 25 and one investigated cotton and synthetic fibres. 26 Since the start of the trial, an additional study on chitosan-coated textiles has been published.…”

Functional textiles for atopic dermatitis: a systematic review and meta‐analysis

“…The interventions included silver , silk , borage oil , and EVOH fiber used for a period of 1–12 wk. RCTs addressed silk textiles in two studies , silver‐coated textiles in 4 , and borage oil and EVOH fiber in one study each. The case–control studies analyzed silk fabric and silver‐coated textile .…”

“…Silk textiles were also examined in one side‐by‐side comparison study and one uncontrolled study . Silver‐coated fabrics were studied in both children and adults in all cases . Silk, by contrast, was studied mostly in children , and borage oil and EVOH fiber were studied in children only.…”

“…Control textiles included cotton (for studies of silver, borage oil, and EVOH fiber) and regular silk for studies of silk with AEGIS antibacterial treatment . All the studies addressed eczema severity, measured by SCORAD and the Eczema Area and Severity Index (EASI) . The skin microbiome was analyzed in studies of silver and silk , while skin physiology was studied in those of silver and borage oil .…”

Leitlinie Neurodermitis [atopisches Ekzem; atopische Dermatitis]

“…In einer kleinen Pilotstudie wurden der klinische Effekt und biophysikalische Eigenschaften eines silberbeschichteten Zellulose‐Stoffs mit inkorporiertem Meerestang bei zwölf Patienten mit mittelschwerer bis schwerer Neurodermitis untersucht . Hierbei trugen die Patienten Top und Leggings, die – i. S. eines Rechts‐Links‐Vergleichs – jeweils zu einem Teil aus dem o. a.…”