A pilot study of the effects of intranasal budesonide delivered by NasoNeb® on patients with perennial allergic rhinitis

Brown, Kristal; Lane, James D.; Silva, Marianella Paz; deTineo, Marcy; Naclerio, Robert M.; Baroody, Fuad M.

doi:10.1002/alr.21239

Cited by 9 publications

(19 citation statements)

References 26 publications

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“…Nebulized corticosteroids showed a higher decrease of the total score of symptoms than saline solution nebulization even if the difference in change was not always significantly different (14,20) .…”

Section: Effects On Symptomsmentioning

confidence: 78%

“…After duplicates removal, 506 articles were identified and screened. At the end of the process, eight RCT were included in the systematic review (13)(14)(15)(16)(17)(18)(19)(20) . (19) , Total Nasal Symptom Score (15,24) , Lund-Kennedy Score (18) and Sino-Nasal Outcome Test (SNOT-20) (17) .…”

Section: Study Selectionmentioning

confidence: 99%

“…Acoustic rhinometry was used in one study to quantify the volume of nasal cavity and the resistance of upper airways (14) . The Peak Nasal Inspiratory Flow (PNIF) was also used as a marker of efficacy in the same study (14) .…”

Section: Study Selectionmentioning

confidence: 99%

“…Different devices were found in the studies. Six studies used specific nebulizer to target the sinus (14,15,17,20,22) but only 4 out of them performed the administration with a sonic nebulizers (15,17,20,22) . Particle size was determined in 3 studies and the mass median aerodynamic diameter varied from 3.2 to 30 µm (19,23) .…”

Section: Interventionsmentioning

confidence: 99%

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Clinical efficacy of intranasal drug delivery by nebulization in chronic rhinosinusitis: a systematic review

Reychler

Domachowski

Latiers

et al. 2018

Rhin

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Background: Treatment of chronic rhinosinusitis (CRS) aims to treat the underlying inflammation or infection. Although the optimal modality of administration remains controversial, inhalation route is usually preferred. The aim of this systematic review was to summarize the efficacy of intranasal corticoisteroids or antibiotics delivery by nebulization on symptoms, histology, endoscopy scores, nasal obstruction, clinical outcomes and quality of life in CRS.Method: This systematic review followed the PRISMA guidelines. Randomized controlled, comparative and cohort studies evaluating effects of treatment by nebulization in sinusitis were identified and reviewed from two databases (PubMed and Scopus). Two reviewers independently assessed study quality and reviewed the selected studies.Results: 600 references were retrieved and 12 studies evaluating 377 patients were included in the systematic review. Different devices were used. Efficacy of nasal delivery by nebulization was systematically observed on symptoms and size of polyps and frequently on inflammatory parameters in all studies. The presence of polyps improved the efficacy of the nebulization. This way of delivery appears not convincing regarding antibiotics. Few side effects were noted in the retrieved studies and only for nebulized antibiotics. Conclusions:This systematic review highlighted that based on the present literature nebulization is not better than nasal spray to the delivery of corticosteroids due to the positive results on symptoms, endoscopic appearance and histological outcomes. For antibiotics delivery, the nebulization is not of added value.

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Section: Effects On Symptomsmentioning

confidence: 78%

Section: Study Selectionmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

Section: Interventionsmentioning

confidence: 99%

See 2 more Smart Citations

Clinical efficacy of intranasal drug delivery by nebulization in chronic rhinosinusitis: a systematic review

Reychler

Domachowski

Latiers

et al. 2018

Rhin

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“…Liu and Davis, et al examine this particular question and find no objective or subjective evidence of harm to the olfactory system as a result of saline irrigation. The topical nebulized use of budesonide is studied in patients with allergic rhinitis by Brown and Baroody, et al who find trends in the favor of the treatment arm but not statistical significance in most parameters. I would suggest that “clinically significant” effects might be even more challenging to demonstrate and look forward to future studies.…”

mentioning

confidence: 99%

Editorial

Smith¹

2014

Int Forum Allergy Rhinol

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Assessment of three types of intranasal nebulization devices in three‐dimensional printed models and volunteers: a pilot study

Dong

Cai

Huang

et al. 2020

Int Forum Allergy Rhinol

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Background Intranasal nebulization is an effective treatment for chronic rhinosinusitis and allergic rhinitis however terminal inhalation devices have not been fully studied We compared the sinonasal aerosol distributions and adverse effects of different inhalation units Methods A mask double-head nozzle and single-head nozzle were applied to atomize the methylene blue solution to-dimensional printed models of the pediatric nasal cavity adult nasal cavity with septal deviation and postsurgical paranasal sinuses and staining of the different sites was scored Volunteers received nebulization of normal saline via different devices therea er the adverse effects were assessed using the visual analogue scale VAS Results A er nebulization the staining scores for the middle turbinate and middle meatus of the pediatric and adult nasal cavity models and the score for the anterior ethmoid sinus of the sinus model with the single-head nozzle were significantly higher than those with the mask and double-head nozzle all p < η for effect size estimates were above Among the volunteers the adverse effects including nasal irritation facial pressure/pain ear full-ness/pain postnasal drip and throat irritation/cough were mild The variations in the incidence and VAS scores of the adverse effects among the devices were not significant all p > Conclusion The single-head nozzle was the most effective device in aerosol delivery to the lateral wall of the nasal cavity and sinuses conversely the mask yielded limited sinonasal deposition Intranasal nebulization was well tolerated and the adverse effects among the devices were comparable These findings are meaningful for selecting and developing inhalation units © 2020 ARS-AAOA, LLC.

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A pilot study of the effects of intranasal budesonide delivered by NasoNeb® on patients with perennial allergic rhinitis

Cited by 9 publications

References 26 publications

Clinical efficacy of intranasal drug delivery by nebulization in chronic rhinosinusitis: a systematic review

Clinical efficacy of intranasal drug delivery by nebulization in chronic rhinosinusitis: a systematic review

Editorial

Assessment of three types of intranasal nebulization devices in three‐dimensional printed models and volunteers: a pilot study

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