A pilot study of the acceptability, feasibility and safety of yoga for chronic pain in sickle cell disease

Bakshi, Nitya; Cooley, Anthony; Ross, Diana; Hawkins, Lauren; Sullivan, Marlysa; Astles, Rachel; Sinha, Cynthia; Katoch, Deeksha; Peddineni, Manasa; Gee, Beatrice E.; Lane, Peter A.; Krishnamurti, Lakshmanan

doi:10.1016/j.ctim.2021.102722

Cited by 11 publications

(8 citation statements)

References 41 publications

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“…Investigators in a recent feasibility study of outpatient yoga for chronic pain in SCD noted similar challenges with scheduling, transportation, and reaching participants by phone. 54 Thus, it is important to address logistical and technological barriers to engagement among patients with SCD when implementing this intervention.…”

Section: Discussionmentioning

confidence: 99%

Effects of Music Therapy on Quality of Life in Adults with Sickle Cell Disease (MUSIQOLS): A Mixed Methods Feasibility Study

Rodgers-Melnick

Lin

Gam

et al. 2022

JPR

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Purpose: To investigate the feasibility, acceptability, and preliminary efficacy of a 6-session music therapy protocol on self-efficacy, quality of life, and coping skills in adults with sickle cell disease (SCD). Patients and Methods: Using a mixed-methods intervention design, adults with SCD (ages 21-57; mean age 32.33) were randomized (1:1) to either 1) a 6-session music therapy (MT) intervention (n = 12) or 2) waitlist control (WLC) (n = 12) using stratified randomization where factors were age in years (≤30 vs >30), and sex (male, female). All participants completed two weeks of daily electronic pain diary entries and self-efficacy, quality of life, and coping skills measures before and after their assigned study condition to explore preliminary efficacy. MT participants were taught music exercises accessed via smartphone and subsequently interviewed to determine feasibility and acceptability. Results: The enrollment rate was 89%. All study measures were completed, with high rates of electronic pain diary completion at baseline (70%) and 2-week follow-up (66%). Interviews revealed two overall themes related to MT participants' experience: 1) participants learned new self-management skills and 2) MT improved participants' ability to cope with pain. MT participants demonstrated 100% attendance. In preliminary analyses, MT participants demonstrated significant improvements (means ± SD) in self-efficacy (5.42 ± 5.43, p = 0.008, d = 1.20), PROMIS sleep disturbance (−1.49 ± 6.68, p = 0.023, d = −0.99), PROMIS pain interference (−2.10 ± 4.68, p = 0.016, d = −1.06), and ASCQ-Me social functioning impact scores (2.97 ± 6.91, p = 0.018, d = 1.05) compared to WLC participants. Conclusion: Preliminary findings support the feasibility and acceptability of music therapy for home use in adults with SCD. While music therapy may assist adults with SCD in improving self-efficacy and quality of life, subsequent, fully-powered clinical research is needed to determine its efficacy.

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Section: Discussionmentioning

confidence: 99%

Effects of Music Therapy on Quality of Life in Adults with Sickle Cell Disease (MUSIQOLS): A Mixed Methods Feasibility Study

Rodgers-Melnick

Lin

Gam

et al. 2022

JPR

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“…Early intervention may also delay the onset and frequency of pain crises and reduce the severity of the disease and comorbidities. [ 48 49 ]…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that CAM therapies are well accepted by SCD patients. [ 49 ] Prayer was the most commonly used CAM therapy to manage painful episodes. Although relaxation techniques and exercises come across as most beneficial, they are not as commonly used as prayer.…”

Section: Discussionmentioning

confidence: 99%

Yoga Module Development and Validation for Sickle Cell Disease

Zaidi,

Mithila,

Mavathur

et al. 2023

International Journal of Yoga

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Introduction: Sickle cell disease (SCD) is a genetic blood disorder that affects the shape and function of red blood cells (RBCs), which can lead to several health problems affecting the quality of life. SCD can be treated with certain expensive treatments such as RBC transfusion, hydroxyurea, stem cell transplantation, gene therapy, or bone marrow transplant. However, some of the most common symptoms such as pain, anxiety, and stress can also be alleviated with alternative therapies like yoga. In light of this, there is a need for the development of a specific yoga module (YM) for SCD that can complement the current therapies. Objective: To develop and validate a YM for SCD. Methodology: Concise literature reports on yoga practices used for varied symptoms/comorbidities associated with SCD were compiled and presented to focus groups. Based on the presented report and personal experience, the focus group created a preliminary version of the module. The preliminary module was further refined based on content validity ratio (CVR) following module validation by 33 yoga experts. Results: One hour ten minutes module developed by the focus group had in total 27 practices including, loosening exercises, asanas, pranayama, relaxation techniques, and meditation. After validation by the experts, 21 practices with a CVR ≥ 0.33 were retained. The predominant reason for excluding 12 practices was intensity, which may have some adverse effect on sickle cell comorbidities. Conclusion: The module developed is the first validated module for SCD.

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“…Few studies have investigated the benefits of yoga and mindfulnessbased interventions in the SCD population [10,11]. The American Society of Hematology 2020 guidelines offer a conditional recommendation based on "very low certainty in the evidence" for yoga therapy as an adjunctive management strategy for acute pain in SCD.…”

Section: Introductionmentioning

confidence: 99%

Mindfulness and yoga therapy for acute pain in sickle cell disease

Dev,

Bavli,

Sims

et al. 2023

eJHaem

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There is a paucity of data regarding the use of non‐pharmacologic therapies for pain in sickle cell disease. The purpose of this pilot study was to assess the acceptability and feasibility of video‐guided mindfulness meditation, breathing exercises, and yoga, in addition to standard of care, during admission for painful vaso‐occlusive crisis. Feasibility was demonstrated by the enrollment rate of > 90% and high level of participant engagement in the intervention. Acceptability was demonstrated by positive feedback obtained in post‐intervention surveys and the majority of subjects who expressed interest in participating in future mindfulness and yoga therapy sessions.

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A pilot study of the acceptability, feasibility and safety of yoga for chronic pain in sickle cell disease

Cited by 11 publications

References 41 publications

Effects of Music Therapy on Quality of Life in Adults with Sickle Cell Disease (MUSIQOLS): A Mixed Methods Feasibility Study

Effects of Music Therapy on Quality of Life in Adults with Sickle Cell Disease (MUSIQOLS): A Mixed Methods Feasibility Study

Yoga Module Development and Validation for Sickle Cell Disease

Mindfulness and yoga therapy for acute pain in sickle cell disease

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