In certain situations, romantic engagement with a partner can have detrimental effects on an individual’s well-being and overall health, exhibiting features attributable to addictive behaviors. Considering the clinical significance of this phenomenon and its prevalence among adolescents and young adults, the objective of this study was to investigate the potential associations between some risk factors for love addiction in a sample of university students, with a specific focus on adult attachment, separation anxiety, and defense mechanisms. A total of 332 participants (Mage = 23 years; SD = 2.462) completed a survey consisting of the Love Addiction Inventory—Short Form, Relationship Questionnaire, Seven Domains Addiction Scale (Separation Anxiety domain), and Forty Item Defense Style Questionnaire. The data were analyzed using Pearson’s correlation, and a multiple mediation model was also implemented. Results showed that fearful attachment was significantly and positively associated with love addiction. Furthermore, this relationship was mediated by separation anxiety and neurotic/immature defense mechanisms too. These findings contribute to the existing literature on love addiction and provide valuable insights for future research and clinical practice.