A pilot study on environmental and behavioral factors related to missed abortion

Zhang, Xueyan; Li, Jian; Gu, Yiqun; Zhao, Yiming; Wang, Zhongxu; Chen, Zhangjian

doi:10.1007/s12199-010-0196-4

Cited by 28 publications

(17 citation statements)

References 19 publications

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“…In contrast to findings from RCTs, non-randomised intervention and cohort studies, the case–control study by Zhang showed a protective dose–response effect of exercise on the odds of miscarriage 5353. Similar to the other study designs, the study by Maconochie (2007) found no association between strenuous exercise (once/week; 2–3/week; >4/week) compared with rare or no exercise and odds of miscarriage (cases, n=603; controls, n=6116; OR 1.00–1.31, 95% CI 0.75 to 2.00, adjusted for year of conception, maternal age, previous miscarriage and previous live birth) 54…”

Section: Resultscontrasting

confidence: 65%

Prenatal exercise is not associated with fetal mortality: a systematic review and meta-analysis

et al. 2018

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ObjectiveTo perform a systematic review of the relationship between prenatal exercise and fetal or newborn death.DesignSystematic review with random-effects meta-analysis and meta-regression.Data sourcesOnline databases were searched up to 6 January 2017.Study eligibility criteriaStudies of all designs were included (except case studies) if they were published in English, Spanish or French and contained information on the population (pregnant women without contraindication to exercise), intervention (subjective or objective measures of frequency, intensity, duration, volume or type of exercise, alone [“exercise-only”] or in combination with other intervention components [eg, dietary; “exercise + co-intervention”]), comparator (no exercise or different frequency, intensity, duration, volume and type of exercise) and outcome (miscarriage or perinatal mortality).ResultsForty-six studies (n=2 66 778) were included. There was ‘very low’ quality evidence suggesting no increased odds of miscarriage (23 studies, n=7125 women; OR 0.88, 95% CI 0.63 to 1.21, I2=0%) or perinatal mortality (13 studies, n=6837 women, OR 0.86, 95% CI 0.49 to 1.52, I2=0%) in pregnant women who exercised compared with those who did not. Stratification by subgroups did not affect odds of miscarriage or perinatal mortality. The meta-regressions identified no associations between volume, intensity or frequency of exercise and fetal or newborn death. As the majority of included studies examined the impact of moderate intensity exercise to a maximum duration of 60 min, we cannot comment on the effect of longer periods of exercise.Summary/conclusionsAlthough the evidence in this field is of ‘very low’ quality, it suggests that prenatal exercise is not associated with increased odds of miscarriage or perinatal mortality. In plain terms, this suggests that generally speaking exercise is ‘safe’ with respect to miscarriage and perinatal mortality.

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Section: Resultscontrasting

confidence: 65%

Prenatal exercise is not associated with fetal mortality: a systematic review and meta-analysis

et al. 2018

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“…Conceptual framework for the potential mechanistic links between neighborhood land use and public health. a positive effect on mental and physical health (Bowler et al, 2010;Richardson, and Mitchell, 2010;Zhang et al, 2011). Scholars have associated green spaces with decreased risks of cardiovascular and cerebrovascular diseases, missed abortions, low birth weight, cancer, and mental problems (Barton and Pretty, 2010;Dadvand et al, 2012;Richardson and Mitchell, 2010;Gascon et al, 2016;Sugiyama et al, 2016).…”

Section: Literature Reviewmentioning

confidence: 99%

“…We obtain several results that are consistent with previous studies. First, higher abundance of green land would reduce the risk of a diversity of diseases (e.g., asthma, low birth weight, mental health, cardiopathy, obesity, and hypertension) (Alcock et al, 2015;Bowler et al, 2010;Gascon et al, 2016;Zhang et al, 2011). Second, higher risk of cancer, mortality, and low birth weight would be observed in neighborhood with more land delineated for industry (Cambra et al, 2011;Hendryx et al, 2012;Lopez-Cima et al, 2011).…”

Section: Public Health In Linkage To Land Usementioning

confidence: 99%

Public health in linkage to land use: Theoretical framework, empirical evidence, and critical implications for reconnecting health promotion to land use policy

Zhang

et al. 2016

Land Use Policy

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“…At present the association between folate insufficiency and the onset of placenta-mediated diseases, such as spontaneous abortion [58-65], preterm birth [66-75], foetal growth retardation [76-80], pre-eclampsia [81-88], abruptio placentae [89] and stillbirth [90] is still not entirely clear.…”

Section: Introductionmentioning

confidence: 99%

Prevention of congenital malformations and other adverse pregnancy outcomes with 4.0 mg of folic acid: community-based randomized clinical trial in Italy and the Netherlands

Bortolus

Blom

Filippini

et al. 2014

BMC Pregnancy Childbirth

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BackgroundIn 2010 a Cochrane review confirmed that folic acid (FA) supplementation prevents the first- and second-time occurrence of neural tube defects (NTDs). At present some evidence from observational studies supports the hypothesis that FA supplementation can reduce the risk of all congenital malformations (CMs) or the risk of a specific and selected group of them, namely cardiac defects and oral clefts. Furthermore, the effects on the prevention of prematurity, foetal growth retardation and pre-eclampsia are unclear.Although the most common recommendation is to take 0.4 mg/day, the problem of the most appropriate dose of FA is still open.The aim of this project is to assess the effect a higher dose of peri-conceptional FA supplementation on reducing the occurrence of all CMs. Other aims include the promotion of pre-conceptional counselling, comparing rates of selected CMs, miscarriage, pre-eclampsia, preterm birth, small for gestational age, abruptio placentae.Methods/DesignThis project is a joint effort by research groups in Italy and the Netherlands. Women of childbearing age, who intend to become pregnant within 12 months are eligible for the studies. Women are randomly assigned to receive 4 mg of FA (treatment in study) or 0.4 mg of FA (referent treatment) daily. Information on pregnancy outcomes are derived from women-and-physician information.We foresee to analyze the data considering all the adverse outcomes of pregnancy taken together in a global end point (e.g.: CMs, miscarriage, pre-eclampsia, preterm birth, small for gestational age). A total of about 1,000 pregnancies need to be evaluated to detect an absolute reduction of the frequency of 8%. Since the sample size needed for studying outcomes separately is large, this project also promotes an international prospective meta-analysis.DiscussionThe rationale of these randomized clinical trials (RCTs) is the hypothesis that a higher intake of FA is related to a higher risk reduction of NTDs, other CMs and other adverse pregnancy outcomes. Our hope is that these trials will act as catalysers, and lead to other large RCTs studying the effects of this supplementation on CMs and other infant and maternal outcomes.Trial registrationItalian trial: ClinicalTrials.gov Identifier: NCT01244347.Dutch trial: Dutch Trial Register ID: NTR3161.

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A pilot study on environmental and behavioral factors related to missed abortion

Abstract: Physical exercise, ventilation, folic acid supplements, and supervisor support were identified as protective factors for the prevention of missed abortion. Advanced age at pregnancy was a risk factor for missed abortion.

Cited by 28 publications

References 19 publications

Prenatal exercise is not associated with fetal mortality: a systematic review and meta-analysis

Prenatal exercise is not associated with fetal mortality: a systematic review and meta-analysis

Public health in linkage to land use: Theoretical framework, empirical evidence, and critical implications for reconnecting health promotion to land use policy

Prevention of congenital malformations and other adverse pregnancy outcomes with 4.0 mg of folic acid: community-based randomized clinical trial in Italy and the Netherlands

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