A Pilot Study on Oxidative Stress during the Recovery Phase in Critical COVID-19 Patients in a Rehabilitation Facility: Potential Utility of the PAOT® Technology for Assessing Total Anti-Oxidative Capacity

Pincemaïl, Joël; Rousseau, Anne-Françoise; Kaux, Jean-François; Cheramy-Bien, Jean-Paul; Bruyère, Christine; Prick, Jeanine; Stern, David; Kaci, Mouna-Messaouda; Noordhout, B. Maertens de; Albert, Adelin; Eubelen, Céline; Goff, Caroline Le; Benoît, Michel; Cavalier, Étienne; Charlier, Corinne; Meziane, Smail

doi:10.3390/biomedicines11051308

Cited by 3 publications

(1 citation statement)

References 94 publications

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“…Pincemail et al . [ 22 ] in a recent study reported that oxidative stress was found to be higher during the recovery phase of critical COVID-19 patients and found that salivary TAC levels were decreased, which is in accordance with the present study.…”

Section: Discussionsupporting

confidence: 93%

Prevalence of dental caries among coronavirus disease 2019-recovered patients and correlation with salivary total antioxidant capacity in Kalaburagi region of Indian subpopulation

Halkai,

Halkai

2024

Journal of Conservative Dentistry and Endodontics

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Background: Coronavirus disease 2019 (COVID-19) has vastly affected mankind worldwide, and its long-term effect on oral health needs to be studied. Aims: The aim of the study was to evaluate the prevalence of dental caries and its correlation with salivary total antioxidant capacity (TAC) in Kalaburagi region of the Indian subpopulation. Methods: About 80 subjects (16–55 years) were included in the study based on selection criteria and were divided into two groups (n = 40). Group 1: no history of COVID-19 infection and Group 2: COVID-19-recovered subjects. Each group was subdivided into two subgroups (n = 20) A and B with and without dental caries. Dental caries was assessed using the decay, missing, filled, treatment (DMFT) index by the World Health Organization. About 5 ml of unstimulated saliva samples was collected and centrifuged at 2000 rpm for 10 min, and the supernatants were collected. Salivary TAC was estimated using 2,2′-azino-bis-[3-ethylbenzothiazoline-6-sulfonic] acid assay and observed under spectrophotometer (734 nm). Statistical Analysis: Data were analyzed using the Shapiro–Wilk test for normality distribution followed by one-way analysis of variance and post hoc Tukey test (P < 0.05). Results: COVID-19-recovered subjects showed a higher prevalence of dental caries and lower TAC levels than non-COVID-19 subjects. Conclusion: Higher prevalence of dental caries with lower levels of salivary TAC was found in COVID-19-recovered individuals.

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Section: Discussionsupporting

confidence: 93%

Prevalence of dental caries among coronavirus disease 2019-recovered patients and correlation with salivary total antioxidant capacity in Kalaburagi region of Indian subpopulation

Halkai,

Halkai

2024

Journal of Conservative Dentistry and Endodontics

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Oxidative stress markers and prediction of severity by a machine learning approach in hospitalized patients with COVID-19 and severe lung disease: a feasibility study (Preprint)

RASPADO,

BRACK,

BRACK

et al. 2024

Preprint

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BACKGROUND Oxidative Stress (OS) is an imbalance between the production of free radicals and the body's ability to neutralize them, leading to damages of cells, proteins and deoxyribonucleic. OBJECTIVE To identify the relevant biomarkers of OS which could be associated to severity of hospitalized patients and to identify a possible correlation between OS biomarkers and clinical status of hospitalized COVID-19 patients with severe lung disease at hospital admission. METHODS All adult patients hospitalized with COVID-19 at the Infirmerie Protestante (Lyon, France) from 9th February 2022 to 18th May 2022 were included, regardless of the care service. The final sample consisted in 28 patients. Ten biomarkers were collected per patient (Zinc (Zn), Copper (Cu), Cu/Zn, Selenium, Uric acid, CRplus, Oxidized LDL, Glutathione peroxidase, Glutathione reductase and Thiols), as well as demographic variables and comorbidities. A support vector machine (SVM) model was used to predict the severity grade per patient, based on the collected data as training set. RESULTS : Three biomarkers of OS were associated with severity; Zn, Cu/Zn and Thiols especially for grade 0 (asymptomatic) and grade 1 (mild to moderate severity). The SVM model predicted the level of severity from the biological analysis of the OS biomarkers with only 7.14% of discrepancy in the training dataset. CONCLUSIONS In case of COVID-19 infection, moderate to severe symptomatic patients are associated with a lowered zinc level, a lowered plasma thiol level, an increased CRPus and an increased Cu/Zn ratio among a panel of ten biomarkers of OS.

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Alteration of Blood Oxidative Stress Status in Patients with Thoracic Aortic Dissection: A Pilot Study

et al. 2023

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Background: Thoracic aortic dissection (TAD) is a life-threatening condition which usually occurs on an aneurysmal aortic wall. Although increasing data have shown that inflammation and oxidative stress play an important role in the patho-physiology of dissection, systemic oxidative stress status (OSS) has not been clearly determined in patients suffering from TAD. Methods: A cohort of 115 patients presenting type A or B TAD were admitted to our center from 2013 to 2017. Out of this cohort, 46 patients were included in a study on dissected aorta (LIege study on DIssected Aorta: LIDIA). In 18 out of the 46 patients, systemic OSS parameters were evaluated after TAD diagnosis by determination of eight different antioxidants, four trace elements, two markers of oxidative lipid damage and two inflammatory markers. Results: The 18 TAD patients included 10 men and 8 women (median age: 62 years; interquartile range: 55–68) diagnosed with type A (N = 8) or B (N = 10) TAD. Low plasma levels of vitamin C, β-carotene, γ-tocopherol, thiol proteins, paraoxonase and selenium were observed in these 18 patients. By contrast, the concentration of copper and total hydroperoxides, copper/zinc ratio, as well as inflammatory markers, were higher than the reference intervals. No difference was observed in oxidative stress biomarker concentrations between type A and B TAD patients. Conclusions: This pilot study, limited to 18 TAD patients, revealed a heightened systemic OSS, determined at 15.5 days (median) after the initial diagnosis, in those TAD patients without complications (malperfusion syndrome and aneurysm formation). Larger studies on biological fluids are needed to better characterize the oxidative stress and interpret its consequence in TAD disease.

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A Pilot Study on Oxidative Stress during the Recovery Phase in Critical COVID-19 Patients in a Rehabilitation Facility: Potential Utility of the PAOT® Technology for Assessing Total Anti-Oxidative Capacity

Cited by 3 publications

References 94 publications

Prevalence of dental caries among coronavirus disease 2019-recovered patients and correlation with salivary total antioxidant capacity in Kalaburagi region of Indian subpopulation

Prevalence of dental caries among coronavirus disease 2019-recovered patients and correlation with salivary total antioxidant capacity in Kalaburagi region of Indian subpopulation

Oxidative stress markers and prediction of severity by a machine learning approach in hospitalized patients with COVID-19 and severe lung disease: a feasibility study (Preprint)

Alteration of Blood Oxidative Stress Status in Patients with Thoracic Aortic Dissection: A Pilot Study

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