A pilot study to assess near infrared laparoscopy with indocyanine green (ICG) for intraoperative sentinel lymph node mapping in early colon cancer

Currie, Andrew; Brigic, A; Thomas-Gibson, Siwan; Suzuki, Noriko; Moorghen, Morgan; Jenkins, John T.; Faiz, O; Kennedy, R. H.

doi:10.1016/j.ejso.2017.05.026

Cited by 71 publications

(70 citation statements)

References 33 publications

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“…Several studies have found that the detection rate for sentinel nodes using ICG is relatively high [23, 25, 27-30]. The studies varied in their method of instilling the tracer, with some using laparoscopic insertion of the dye through the serosa and others using colonoscopic administration.…”

Section: Resultsmentioning

confidence: 99%

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Intraoperative Sentinel Node Mapping in the Colon: Potential and Pitfalls

Currie¹

2019

Eur Surg Res

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Sentinel lymph node mapping (SLNM) may play a significant role in future delivery of colon cancer surgery because of an increase in early-stage, node-negative disease due to national bowel cancer screening programmes. Traditionally, colon lymphatic drainage has not been thought relevant as the operative approach cannot be tailored. Recent advances in local and endoscopic risk-reducing interventions for colonic malignancy have caused a rethink in approach. SLNM was initially attempted with blue dye techniques with limited success. Technological improvement has allowed surgeons to use near-infrared (NIR) light and NIR active tracers such as indocyanine green. This review provides an overview of the current status of intraoperative lymph node mapping in the colon, identifies challenges to the delivery of the techniques, and discusses potential solutions that may help SLNM play a role in improving the delivery of surgical care for patients with colon cancer.

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Section: Resultsmentioning

confidence: 99%

“…Currie et al [30] identified 6 false-negative nodes in the 9 patients with lymphatic metastases who had sentinel nodes detected. Cahill et al [25] undertook NIR lymphatic mapping using ICG alone in 18 patients (14 with non-metastatic colorectal cancer, 4 with endoscopically unresectable polyps).…”

Section: Resultsmentioning

confidence: 99%

Intraoperative Sentinel Node Mapping in the Colon: Potential and Pitfalls

Currie¹

2019

Eur Surg Res

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“…Moreover, the method seems to be also effective in obese patients, providing an efficient detection of the sentinel nodes (5,25). a large study which came to demonstrate the efficacy of the method in colorectal cancer patients comes from a. C. Curie et al and was published in 2017 in the european Journal of Surgical Oncology (26). the paper included 30 patients with t1 and t2 colonic cancer who were submitted to peritumoral submucosal injection of ICg through an endoscopic approach, followed by laparoscopic resection; in terms of surgical technique, in all cases a medial to lateral, vessel first technique was performed.…”

Section: Indocyanine Green (Icg) Staining For Sentinel Lymph Node Detmentioning

confidence: 99%

Sentinel lymph node in colorectal cancer

Bacalbaşa¹,

Bălescu²,

Dimitriu³

et al. 2019

Ro Med J.

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“…Optical imaging using fluorescent probes has been preclinically and clinically used for imaging of superficial tissue, tissue that can be accessed endoscopically or laparoscopically, [17][18][19][20] internal tissue imaging during surgical procedures (intraoperative fluorescence imaging or fluorescence-guided surgery), 21,22 and ex vivo analysis of diseased tissue after in vivo probe administration. 23,24 Specifically, clinical fluorescence imaging has been readily used for imaging of tissue perfusion, fluorescence-guided surgery, 21,22 sentinel lymph-node mapping and general lymphography, 20,[25][26][27] detection of premalignant/malignant lesions (ClinicalTrials.gov; NCT02113202 and NCT01972373), and tumor identification and margin detection, 24,[28][29][30] among other applications. Several fluorescence-imaging systems, including the SPY system from Novadaq Technologies, and fluorescent contrast agents, including indocyanine green, methyl blue, and fluorescein, have been US Food and Drug Administration-approved for clinical use, boding well for the translational future of fluorescence-based theranostic nanomedicines.…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin-loaded protease-activated near-infrared fluorescent polymeric nanoparticles for imaging and therapy of cancer

Yildiz¹,

Gu²,

Zauscher³

et al. 2018

IJN

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IntroductionDespite significant progress in the field of oncology, cancer remains one of the leading causes of death. Chemotherapy is one of the most common treatment options for cancer patients but is well known to result in off-target toxicity. Theranostic nanomedicines that integrate diagnostic and therapeutic functions within an all-in-one platform can increase tumor selectivity for more effective chemotherapy and aid in diagnosis and monitoring of therapeutic responses.Material and methodsIn this work, theranostic nanoparticles were synthesized with commonly used biocompatible and biodegradable polymers and used as cancer contrast and therapeutic agents for optical imaging and treatment of breast cancer. These core–shell nanoparticles were prepared by nanoprecipitation of blends of the biodegradable and biocompatible amphiphilic copolymers poly(lactic-co-glycolic acid)-b-poly-l-lysine and poly(lactic acid)-b-poly(ethylene glycol). Poly-l-lysine in the first copolymer was covalently decorated with near-infrared fluorescent Alexa Fluor 750 molecules.ResultsThe spherical nanoparticles had an average size of 60–80 nm. The chemotherapeutic drug doxorubicin was encapsulated in the core of nanoparticles at a loading of 3% (w:w) and controllably released over a period of 30 days. A 33-fold increase in near-infrared fluorescence, mediated by protease-mediated cleavage of the Alexa Fluor 750-labeled poly-l-lysine on the surface of the nanoparticles, was observed upon interaction with the model protease trypsin. The cytocompatibility of drug-free nanoparticles and growth inhibition of drug-loaded nanoparticles on MDA-MB-231 breast cancer cells were investigated with a luminescence cell-viability assay. Drug-free nanoparticles were found to cause minimal toxicity, even at high concentrations (0.2–2,000 µg/mL), while doxorubicin-loaded nanoparticles significantly reduced cell viability at drug concentrations >10 µM. Finally, the interaction of the nanoparticles with breast cancer cells was studied utilizing fluorescence microscopy, demonstrating the potential of the nanoparticles to act as near-infrared fluorescence optical imaging agents and drug-delivery carriers.ConclusionDoxorubicin-loaded, enzymatically activatable nanoparticles of less than 100 nm were prepared successfully by nanoprecipitation of copolymer blends. These nanoparticles were found to be suitable as controlled drug delivery systems and contrast agents for imaging of cancer cells.

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A pilot study to assess near infrared laparoscopy with indocyanine green (ICG) for intraoperative sentinel lymph node mapping in early colon cancer

Cited by 71 publications

References 33 publications

Intraoperative Sentinel Node Mapping in the Colon: Potential and Pitfalls

Intraoperative Sentinel Node Mapping in the Colon: Potential and Pitfalls

Sentinel lymph node in colorectal cancer

Doxorubicin-loaded protease-activated near-infrared fluorescent polymeric nanoparticles for imaging and therapy of cancer

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