A pilot trial of In vivo NRT sampling to increase medication adherence in community corrections smokers

Cropsey, Karen L.; Hendricks, Peter S.; Schiavon, Samantha; Sellers, Aaron; Froelich, Morgan; Shelton, Richard C.; Carpenter, Matthew J.

doi:10.1016/j.addbeh.2016.12.011

Cited by 14 publications

(13 citation statements)

References 40 publications

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“…One explanation for the discrepancy in effectiveness between NRT in trials and NRT bought OTC is low adherence [3, 5, 15, 19, 31, 48, 55]. There is some research to suggest that better adherence is associated with better cessation outcomes [18, 40, 48, 53]. Smartphone applications (apps) could improve NRT adherence and thus success rates in smokers, especially among those using OTC NRT [36, 47, 49].…”

Section: Introductionmentioning

confidence: 99%

Pragmatic randomised trial of a smartphone app (NRT2Quit) to improve effectiveness of nicotine replacement therapy in a quit attempt by improving medication adherence: results of a prematurely terminated study

Herbeć

Brown

Shahab

et al. 2019

Trials

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Background Nicotine replacement therapy (NRT) bought over the counter (OTC) appears to be largely ineffective for smoking cessation, which may be partially explained by poor adherence. We developed and evaluated the NRT2Quit smartphone app (for iOS) designed to improve quit attempts with OTC NRT by improving adherence to the medications. Methods This study was a pragmatic double-blind randomised controlled trial with remote recruitment through leaflets distributed to over 300 UK-based community pharmacies. The study recruited adult daily smokers (≥10 cigarettes per day) who bought NRT, wanted to quit smoking, downloaded NTR2Quit and completed the registration process within the app. Participants were automatically randomly assigned within the app to the intervention (full) version of NRT2Quit or to its control (minimal) versions. The primary outcome was biochemically verified 4-week abstinence assessed at 8-week follow-up using Russell Standard criteria and intention to treat. Bayes factors were calculated for the cessation outcome. Secondary outcomes were self-reported abstinence, NRT use, app use and satisfaction with the app. Results The study under-recruited. Only 41 participants (3.5% of the target sample) were randomly assigned to NRT2Quit ( n = 16) or the control ( n = 25) app versions between March 2015 and September 2016. The follow-up rate was 51.2%. The intervention participants had numerically higher biochemically verified quit rates (25.0% versus 8.0%, P = 0.19, odds ratio = 3.83, 0.61–24.02). The calculated Bayes factor, 1.92, showed that the data were insensitive to test for the hypothesis that the intervention app version aided cessation. The intervention participants had higher median logins (2.5 versus 0, P = 0.01) and were more likely to use NRT at follow-up (100.0% versus 28.6%, P = 0.03) and recommend NRT2Quit to others (100.0% versus 28.6%, P = 0.01). Conclusions Despite very low recruitment, there was preliminary but inconclusive evidence that NRT2Quit may improve short-term abstinence and adherence among smokers using NRT. Well-powered studies on NRT2Quit are needed, but different recruitment methods will be required to engage smokers through community pharmacies or other channels. Trial registration ISRCTN ISRCTN33423896 , prospectively registered on 22 March 2015. Electronic supplementary material The online version of this article (10.1186/s13063-019-3645-4) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Pragmatic randomised trial of a smartphone app (NRT2Quit) to improve effectiveness of nicotine replacement therapy in a quit attempt by improving medication adherence: results of a prematurely terminated study

Herbeć

Brown

Shahab

et al. 2019

Trials

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“…Only the interaction of three intervention components significantly increased both adherence to the nicotine patch and gum and abstinence, perhaps reflecting a causal relation but also reflecting the refractoriness of adherence to treatment. At present, it seems likely that markedly increasing adherent use of NRT would require highly intensive, perhaps multicomponent, intervention efforts, or new approaches (e.g., Cropsey et al 2017). Future analyses with this data set will explore temporal ordering (whether non-adherence precedes lapsing or vice-versa) in order to shed more light on causality.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have found adherent use of medications is strongly related to increased likelihood of abstinence (Catz et al 2011, Lam et al 2005, Ma et al 2016, Mooney et al 2005, Shiffman et al 2008). This strong correlation suggests that increasing adherence causes increased abstinence rates (e.g., Cropsey et al 2017). Of course, relapse may also cause nonadherence (the correlation could, for example, reflect decreased use of medication once a lapse or relapse occurs during a quit attempt).…”

mentioning

confidence: 99%

Can we increase smokers’ adherence to nicotine replacement therapy and does this help them quit?

et al. 2018

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“…Even short-term exposure to smoking cessation medication may be beneficial in increasing the likelihood of adherence in the future. Individuals who utilize smoking cessation medication in the presence of a treatment provider are also more likely to adhere to treatment even if the provider is minimally trained [144]. This is promising for individuals in community corrections, as they may not have consistent access to more highly trained professionals.…”

Section: Smoking Cessationmentioning

confidence: 99%

Assessment and Treatment of Addictions in Community Corrections

Armstrong¹,

Bauman²,

Moroney³

et al. 2021

Addictions - Diagnosis and Treatment

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This chapter discusses the treatment of substance use disorders within community corrections populations. The history of substance abuse treatment within correctional populations is outlined to provide context for the current diversion and rehabilitation models currently in use. Common systems where treatment is provided such as mental health court, drug court, and TASC are described. Common forms of therapy including Cognitive Behavioral Therapy, Mindfulness, social skills training, pharmacotherapy, and smoking cessation are discussed. This chapter focuses on their effectiveness as well as how these forms of therapy differ in community corrections as compared to other populations. Finally, recommendations and future directions for research are provided.

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A pilot trial of In vivo NRT sampling to increase medication adherence in community corrections smokers

Cited by 14 publications

References 40 publications

Pragmatic randomised trial of a smartphone app (NRT2Quit) to improve effectiveness of nicotine replacement therapy in a quit attempt by improving medication adherence: results of a prematurely terminated study

Pragmatic randomised trial of a smartphone app (NRT2Quit) to improve effectiveness of nicotine replacement therapy in a quit attempt by improving medication adherence: results of a prematurely terminated study

Can we increase smokers’ adherence to nicotine replacement therapy and does this help them quit?

Assessment and Treatment of Addictions in Community Corrections

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