A Piperidine Amide Extracted from Piper longum L. Fruit Shows Activity against Aedes aegypti Mosquito Larvae

Yang, Young‐Cheol; Lee, Sang-Guei; Lee, Hee-Kwon; Kim, Moo-Key; Lee, Sang‐Hyun; Lee, Hoi-Seon

doi:10.1021/jf011708f

Cited by 262 publications

(160 citation statements)

References 9 publications

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“…On 1991 Sukumar et al [12] reviewed the use of natural products derived from 344 different plant species to control mosquito populations. Thus, the plant derived products have received increased attention from scientists and nowadays more than 2,000 plant species have already been screened as potent insecticides providing possible lead candidates to replace synthetic chemical insecticides for controlling mosquito larvae [13][14][15][16][17][18][19][20][21][22][23]. In this regard, plant extracts of the Lamiaceae family present an intriguing case, since they comprise a significant source of potential mosquito control agents [12,21].…”

Section: Introductionmentioning

confidence: 99%

Essential Oils of Satureja Species: Insecticidal Effect on Culex pipiens Larvae (Diptera: Culicidae)

Michaelakis

Theotokatos²,

Koliopoulos

et al. 2007

Molecules

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Abstract:The chemical composition of the essential oils of the wild growing plants of Greek S. spinosa L., S. parnassica subsp. parnassica Heldr.& Sart ex Boiss., S. thymbra and S. montana were determined by GC and GC/MS analysis. The larvicidal activities of the essential oils were assayed against Culex pipiens biotype molestus. The analytical data indicated that various monoterpene hydrocarbons and phenolic monoterpenes constitute the major constituents of the oils, but their concentration varied greatly among the oils examined. The bioassay results indicated that the oils possess significant larvicidal activities and represent an inexpensive source of natural substances mixture that exhibit potentials for use to control the mosquito larvae.

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Section: Introductionmentioning

confidence: 99%

Essential Oils of Satureja Species: Insecticidal Effect on Culex pipiens Larvae (Diptera: Culicidae)

Michaelakis

Theotokatos²,

Koliopoulos

et al. 2007

Molecules

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“…1A), an alkaloid/amide component, is one such agent. Derived from the plant species Piper longum Linn, piperlongumine has been shown to possess numerous key biologic activities such as anti-platelet aggregation (17), antibacterial and insecticidal (18), anti-atherosclerotic (19), anxiolytic (20), antidepressant (21), antidiabetic (22,23), anti-inflammatory (23), and antitumor capabilities (24). Among the multivalent effects, the potential of piperlongumine as a novel anticancer agent have gained considerable attention recently.…”

Section: Introductionmentioning

confidence: 99%

Piperlongumine Suppresses Growth and Sensitizes Pancreatic Tumors to Gemcitabine in a Xenograft Mouse Model by Modulating the NF-kappa B Pathway

Wang

Zhou

et al. 2016

Cancer Prevention Research

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Pancreatic cancer is an aggressive malignancy, which generally respond poorly to chemotherapy. Hence, novel agents that are safe and effective are highly needed. The aim of this study was to investigate whether piperlongumine, a natural product isolated from the fruit of the pepper Piper longum, has any efficacy against human pancreatic cancer when used either alone or in combination with gemcitabine in vitro and in a xenograft mouse model. In vitro, piperlongumine inhibited the proliferation of pancreatic cancer cell lines, potentiated the apoptotic effects of gemcitabine, inhibited the constitutive and inducible activation of NF-kB, and suppressed the NF-kB-regulated expression of c-Myc, cyclin D1, Bcl-2, Bcl-xL, Survivin, XIAP, VEGF, and matrix metalloproteinase-9 (MMP-9). Furthermore, in an in vivo xenograft model, we found piperlongumine alone significantly suppressed tumor growth and enhanced the antitumor properties of gemcitabine. These results were consistent with the downregulation of NF-kB activity and its target genes, decreased proliferation (PCNA and Ki-67), decreased microvessel density (CD31), and increased apoptosis (TUNEL) in tumor remnants. Collectively, our results suggest that piperlongumine alone exhibits significant antitumor effects against human pancreatic cancer and it further enhances the therapeutic effects of gemcitabine, possibly through the modulation of NF-kB-and NF-kB-regulated gene products.Cancer Prev Res; 9(3); 234-44. Ó2015 AACR.

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“…In addition, the effect of degradation of a toxic insecticide metabolites in the environment leading to environmental pollution such as pollution of surface water and ground water (Dua et al, 2010) as well as negative effects on non-target organisms, including human (Yang et al, 2002). Recognizing this problem, scientists seek new alternatives in the production of environmentally friendly insecticide and at the same time preventing resistance in the vector.…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness of Organotin (IV) Benzylisopropyldithiocarbamate Compounds as Insecticide Against Aedes Aegypti Linn (Diptera: Culicidae) in Laboratory

Awang¹,

Kosnon

Othman³

et al. 2012

American Journal of Applied Sciences

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Problem statement:The widespread use of insecticides had resulted in insecticide resistance of vectors of dengue as well as polluting the environment. Organotin (IV) compounds had the potential to be developed as the insecticides to overcome the existing problem. Approach: The aim of this study was to examine the insecticidal effects which were larvicidal and adulticidal effects of organotin (IV) benzylisopropyldithiocarbamate compounds against Aedes Aegypti Linn. In laboratory larvicidal bioassay test of a series of three organotin (IV) benzylisopropyldithiocarbamate compounds on third instar larvae of Aedes Aegypti had been carried out. Results: The study was found that compound B showed the best larvicidal effect with the LC 50 and LC 90 values of 0.004 ppm and 0.007 ppm, respectively. Compound C was also displayed good larvicidal effect with the LC 50 and LC 90 values of 0.029 ppm and 0.108 ppm, respectively. While, compound A was shown the least larvicidal effect with the LC 50 and LC 90 values of 0.404 ppm and 0.749 ppm, respectively. Further testing was conducted on compound B on adults of Aedes ageypti female to investigate its adulticidal property. The result showed that compound B displayed good adulticidal activity with LC 50 dan LC 90 of 4.277 ppm and 27.653 ppm, respectively. Conclusion: Compound B is the most effective compound among three organotin (IV) benzylisopropyldithiocarbamate compounds tested against the dengue vector Aedes Aegypti and has potential to be explored as an insecticide to control the spread of dengue fever.

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A Piperidine Amide Extracted from Piper longum L. Fruit Shows Activity against Aedes aegypti Mosquito Larvae

Cited by 262 publications

References 9 publications

Essential Oils of Satureja Species: Insecticidal Effect on Culex pipiens Larvae (Diptera: Culicidae)

Essential Oils of Satureja Species: Insecticidal Effect on Culex pipiens Larvae (Diptera: Culicidae)

Piperlongumine Suppresses Growth and Sensitizes Pancreatic Tumors to Gemcitabine in a Xenograft Mouse Model by Modulating the NF-kappa B Pathway

The Effectiveness of Organotin (IV) Benzylisopropyldithiocarbamate Compounds as Insecticide Against <i>Aedes Aegypti</i> Linn (Diptera: Culicidae) in Laboratory

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