2015
DOI: 10.1016/j.brainres.2015.06.011
|View full text |Cite
|
Sign up to set email alerts
|

A pivotal role for enhanced brainstem Orexin receptor 1 signaling in the central cannabinoid receptor 1-mediated pressor response in conscious rats

Abstract: Orexin receptor 1 (OX 1 R) signaling is implicated in cannabinoid receptor 1 (CB 1 R) modulation of feeding. Further, our studies established the dependence of the central CB 1 R-mediated pressor response on neuronal nitric oxide synthase (nNOS) and extracellular signal-regulated kinase1/2 (ERK1/2) phosphorylation in the RVLM. We tested the novel hypothesis that brainstem orexin-A/OX 1 R signaling plays a pivotal role in the central CB 1 R-mediated pressor response. Our multiple labeling immunofluorescence fin… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
5
0

Year Published

2016
2016
2024
2024

Publication Types

Select...
7
1

Relationship

1
7

Authors

Journals

citations
Cited by 10 publications
(5 citation statements)
references
References 53 publications
(146 reference statements)
0
5
0
Order By: Relevance
“…CB 1 receptors were detected in high densities in many brain regions of humans and experimental animals [ 92 ]. They also occur in brain regions involved in cardiovascular regulation, including the rostral ventrolateral medulla (RVLM; [ 93 , 94 ]), the bed nucleus of the stria terminalis (BNST; [ 95 , 96 ]), the ventral medial prefrontal cortex (vMPFC; [ 97 ]), the paraventricular nucleus of the hypothalamus (PVN; [ 98 ]), the nucleus tractus solitarii (NTS; [ 99 ]) and the dorsal periaqueductal gray (dPAG; [ 97 , 100 ]).…”
Section: Endocannabinoid System In Humans and In Experimental Animals...mentioning
confidence: 99%
“…CB 1 receptors were detected in high densities in many brain regions of humans and experimental animals [ 92 ]. They also occur in brain regions involved in cardiovascular regulation, including the rostral ventrolateral medulla (RVLM; [ 93 , 94 ]), the bed nucleus of the stria terminalis (BNST; [ 95 , 96 ]), the ventral medial prefrontal cortex (vMPFC; [ 97 ]), the paraventricular nucleus of the hypothalamus (PVN; [ 98 ]), the nucleus tractus solitarii (NTS; [ 99 ]) and the dorsal periaqueductal gray (dPAG; [ 97 , 100 ]).…”
Section: Endocannabinoid System In Humans and In Experimental Animals...mentioning
confidence: 99%
“…While a cardioprotective role for endocannabinoids (ECs) might seem unreasonable because current knowledge implicates ECs in diabetes-induced inflammation, oxidative stress, and cardiovascular dysfunction (Horvath et al, 2012), we must consider other important findings. First, the detrimental cardiovascular effects of ECs are mostly mediated by the cannabinoid receptor 1, CB1R (Ibrahim and Abdel-Rahman, 2015; Rajesh et al, 2012; Varga et al, 1995). Second, activation of the novel EC receptor, GPR18, by its endogenous (N-arachidonylglycine; NAGly) (Burstein et al, 2011; Kohno et al, 2006) or synthetic (trans-4-[3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol; abn-cbd) ligand causes hypotension (Offertaler et al, 2003; Parmar and Ho, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…In addition, central activation of CB1 receptors can increase blood pressure along with an increase in the content of orexin A in the rostral ventrolateral medulla. High levels of orexin in rats are associated with higher levels of arousal, which, in turn, can stimulate the breathing process (Ibrahim & Abdel‐Rahman, 2015; Nattie & Li, 2012).…”
Section: Discussionmentioning
confidence: 99%