A placebo controlled investigation into the effects of paroxetine and mirtazapine on measures related to car driving performance

Ridout, Fran; Meadows, Robert; Johnsen, Sigurd; Hindmarch, Ian

doi:10.1002/hup.494

Cited by 63 publications

(49 citation statements)

References 37 publications

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“…BRT is sensitive to psychotropic drug effects and provides results that are consistent with laboratory measures of psychomotor performance (especially CRT). BRT has been shown to be sensitive to various psychoactive compounds Ridout and Hindmarch 2001;Ridout et al 2003b). …”

Section: Brake Reaction Timementioning

confidence: 99%

A double-blind, placebo- and positive-internal-controlled (alprazolam) investigation of the cognitive and psychomotor profile of pregabalin in healthy volunteers

2005

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Section: Brake Reaction Timementioning

confidence: 99%

A double-blind, placebo- and positive-internal-controlled (alprazolam) investigation of the cognitive and psychomotor profile of pregabalin in healthy volunteers

2005

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“…In our study, mirtazapine was most commonly prescribed agent individually 36.26% of total agents, and nearly half of them, i.e., 48% show daytime sleepiness as ADR related to sleep disturbance. Earlier analyses comparing mirtazapine to other antidepressants indicated less nocturnal disturbance and better sleep efficiency than with fluoxetine 6 or paroxetine, 19 and better HAMD sleep scores than with paroxetine 20 or venlafaxine.…”

Section: Discussionmentioning

confidence: 98%

A prospective study on sleep disorders related to antidepressant drugs use in a tertiary care teaching hospital

Khan

Vishwakarma

Giri

et al. 2015

Int J Basic Clin Pharmacol

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Background: Prescription of antidepressants has been increased from the last decade and responsible for producing sleep disorders as adverse drug reactions (ADRs). Sleep disorders can be divided into 3 large groups: (1) insomnia, (2) primary complaint of daytime sleepiness, and (3) Association of disruptive behaviours during sleep, the disorders of arousal. So active surveillance is needed to access these ADRs. Aims and Objective:To analyze the sleep disturbances as ADRs of various antidepressants prescribed to the patients attending psychiatry outpatient department (OPD). Methods: This prospective study was conducted on patients aged ≤74 years attending Department of Psychiatry OPD and were prescribed Antidepressants for the duration of 8 months (December, 2013-July, 2014. The ADRs reported were confirmed by WHO UMC Causality Assessment Scale. Results: Total number of patients enrolled on the basis of inclusion and exclusion criteria (n=50). Total number of ADRs related to drugs prescribed were found to be n=69. Total number of patients with sleep disturbances as ADRs were found to be n=28. Conclusion:The drug, most frequently implicated to cause sleep disturbances, was mirtazapine. Increased sleep was the most common ADR, found to occur. Unusual ADRs such as sleep talking was also seen.

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“…However, results from studies in healthy participants are still inconsistent with respect to their effect of SSRIs on sleep quality. 9,11,12,[17][18][19][20][21][22] Our results suggest that SSRI use is associated with better subjective sleep, after we carefully accounted for presence of depressive symptoms, and ruled out possible effect modification by depressive symptoms. We observed a longer total sleep time, better sleep quality, and higher sleep efficiency.…”

Section: Discussionmentioning

confidence: 98%

“…10,[12][13][14][15][16] Studies in nondepressed individuals regarding the association between SSRIs and subjective sleep reported inconsistent results. 9,11,12,[17][18][19][20][21] Whereas, in clinically depressed patient populations, SSRI use is consistently associated with an improved subjective sleep. 3,9,11,22 The favorable results in depressed populations might represent the improvement of mental health or relief of depressive symptoms.…”

Section: -13mentioning

confidence: 99%

Use of Selective Serotonin Reuptake Inhibitors and Sleep Quality: A Population-Based Study

Aarts

Zuurbier

Noordam

et al. 2016

Journal of Clinical Sleep Medicine

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Study Objectives: Poor sleep is a risk factor for the development and recurrence of depression. Selective serotonin reuptake inhibitor (SSRI) use is consistently associated with good subjective sleep in clinically depressed patient populations. However, studies in the general population are lacking. Our objective was to investigate the association between SSRIs and subjective sleep in a middle-aged and elderly population in a daily practice setting. Methods: We included participants from the prospective Rotterdam Study cohort. Participants had up to two subjective sleep measurements assessed with Pittsburgh Sleep Quality Index ([PSQI], number of measurements = 14,770). SSRI use was based on pharmacy records. We assessed the association between SSRIs and PSQI score and its sub-components, with nonusers of any antidepressant as reference. Analyses were, among others, adjusted for presence of depressive symptoms and concurrent psycholeptic drug use. Results: We included 9,267 participants, average baseline age 66.3 y (standard deviation 10.6), and 57.6% women. SSRI use was significantly associated with a 0.78-point lower PSQI score (95% confidence interval [CI] −1.11; −0.44) which reflects better sleep, compared with non-use. The association was more prominent in continuous SSRI users (−0.71 points, 95% CI −1.18; −0.24). Of the sub-components, SSRIs were associated with 0.70-h longer sleep duration (95% CI 0.56; 0.85), higher sleep quality, higher sleep efficiency, and in contrast more daytime dysfunction. Conclusions: SSRI use was associated with better subjective sleep, after adjustment for depressive symptoms and concurrent psycholeptic drug use. This suggests that, in clinical practice in the middle-aged and elderly population, the sleep quality of some persons may benefit from, continued, SSRI use. Keywords: antidepressive agents, population surveillance, questionnaires, sleep Citation: Aarts N, Zuurbier LA, Noordam R, Hofman A, Tiemeier H, Stricker BH, Visser LE. Use of selective serotonin reuptake inhibitors and sleep quality: a population-based study. J Clin Sleep Med 2016;12(7):989-995. I NTRO DUCTI O NSleep and depression are highly associated. The most common disturbances in the sleep pattern of a depressed person are low sleep efficiency and little deep sleep.1-4 Poor sleep has been shown to be a risk factor for the development or recurrence of depression.2,5-8 However, antidepressant drugs can have positive and negative effects on sleep. 9-13Selective serotonin reuptake inhibitors (SSRIs) are considered as activating antidepressants and a risk factor for poor sleep according to most objective sleep measurements, although sedative properties and daytime somnolence have occasionally been reported for SSRIs. 10,[12][13][14][15][16] Studies in nondepressed individuals regarding the association between SSRIs and subjective sleep reported inconsistent results. 9,11,12,[17][18][19][20][21] Whereas, in clinically depressed patient populations, SSRI use is consistently associated with an improved subjective sle...

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A placebo controlled investigation into the effects of paroxetine and mirtazapine on measures related to car driving performance

Abstract: Paroxetine 20 mg/day has no psychomotor or behavioural toxicity and has no negative impact on BRT. Further research into the chronic and sub-chronic effects of mirtazapine is needed to establish the clinical significance of these results.

Cited by 63 publications

References 37 publications

A double-blind, placebo- and positive-internal-controlled (alprazolam) investigation of the cognitive and psychomotor profile of pregabalin in healthy volunteers

A double-blind, placebo- and positive-internal-controlled (alprazolam) investigation of the cognitive and psychomotor profile of pregabalin in healthy volunteers

A prospective study on sleep disorders related to antidepressant drugs use in a tertiary care teaching hospital

Use of Selective Serotonin Reuptake Inhibitors and Sleep Quality: A Population-Based Study

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