A placebo controlled randomized trial on the effects of supplemental nutrition alone or combined with nandrolone decanoate (decadurabolin) on body composition and physical performance in depleted COPD patients

Schols, A.M.W.J.; Soeters, P.B.; Pluymers, R.J.; Mostert, R.; Wouters, Emiel F.M.

doi:10.1016/0261-5614(93)90235-v

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“…We believe that further studies in the out-patient setting should now assess the effect of nutritional therapy, in conjunction with attempts at promoting anabolism either by pharmacological means (anabolic steroids) [18], or physical training (exercise prescription and respiratory muscle training). …”

Section: Discussionmentioning

confidence: 99%

An out-patient nutritional supplementation programme in COPD patients

Sridhar¹,

Galloway²,

Lean³

et al. 1994

Eur Respir J

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Studies that have assessed the role of nutritional supplementation in patients with emphysematous chronic obstructive pulmonary disease (COPD) have shown conflicting results. Improved respiratory muscle strength and exercise capacity have been demonstrated following intensive and costly nutritional support programmes under controlled conditions. We have evaluated a simple programme of out-patient nutritional support in a clinical setting. Twelve malnourished COPD patients (9 male and 3 female; mean age 66 yrs; < 90% ideal body weight) were studied. Forced vital capacity (FVC), forced expiratory volume in one second (FEV1), estimation of maximal oxygen uptake (VO2max) during exercise, respiratory muscle strength (PImax and PEmax), and measurement of body weight, height, triceps skinfold thickness, and mid-arm muscle circumference were performed before and after a 4 month period of out-patient nutritional support. Patients were advised by a dietician on increasing their daily caloric intake by a minimum of 50% above estimated daily energy expenditure. Three patients withdrew from the study. The mean increase in body weight in the nine remaining patients after 4 months of supplementation was 0.3 kg. There was no significant improvement in the anthropometric measures, lung function, respiratory muscle strength or VO2max for the group as a whole. Three patients who gained more than 1 kg weight were from a higher socioeconomic background compared with those who failed to do so. We conclude that achieving weight gain and improving lung function by means of simple out-patient nutritional programmes in a clinical setting is difficult.

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Section: Discussionmentioning

confidence: 99%