A placebo-controlled trial of Lactobacillus GG to prevent diarrhea in undernourished Peruvian children

Oberhelman, Richard A.; Gilman, Robert H.; Sheen, Patricia; Taylor, David N.; Black, Robert E.; Cabrera, Lilia; Lescano, Andrés G.; Meza, Rina; Madico, Guillermo

doi:10.1016/s0022-3476(99)70366-5

Cited by 245 publications

(138 citation statements)

References 11 publications

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“…The effect is most evident in cases of early treatment of rotavirus infection with oral rehydration therapy associated with Lactobacillus GG [54][55][56][57]. This probiotic is able to decrease the excretion of rotavirus in the stool [58], helping to reduce the spread of the virus, in turn improving the effectiveness of preventive strategies both in communities and during hospitalization. Yet, definitive conclusions cannot be drawn based on the available results [59][60][61].…”

Section: Infectious Gastroenteritismentioning

confidence: 99%

Probiotics and health: An evidence-based review

Aureli

Capurso

Castellazzi

et al. 2011

Pharmacological Research

235

131

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a b s t r a c tThe intestinal microbiota is an ecosystem formed by a variety of ecological niches, made of several bacterial species and a very large amount of strains. The microbiota is in close contact with the intestinal mucosa or epithelial interface which is, after the respiratory area, the largest surface of the body, occupying approximately 250-400 m 2 . The physiological activities of the microbiota are manifold and are just being unraveled. Based on the observations of the multiple roles played by the microbiota in health and disease, the notion of modifying it with appropriate formulations, i.e. probiotics, is being tested in several settings.This review summarizes the current knowledge on probiotics and discusses both limitations and acquired evidence to support their use in preventive and therapeutic medicine.

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Section: Infectious Gastroenteritismentioning

confidence: 99%

Probiotics and health: An evidence-based review

Aureli

Capurso

Castellazzi

et al. 2011

Pharmacological Research

235

131

View full text Add to dashboard Cite

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“…[38] A reduction in incidence of acute diarrheal disease has been reported by another body of literature. Several studies have documented a reduction in incidence or severity of acute diarrhea with Bifidobacteria mainly B. lactis [39,40] and with Lactobacilli, mainly L rhamnosus (GG) [41,42] though protection is not always significant. [43] Both L rhamnosus (GG) and L reuteri (during treatment) [44] and B lactis (used prophylactically) [45] have documented reduced rotaviral shedding.…”

Section: Acute Infectious Diarrheamentioning

confidence: 99%

Probiotics in Pediatrics – Properties, Mechanisms of Action, and Indications

Mavroudi¹

2012

Probiotics

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“…21 However, a study conducted in the outskirts of a Peruvian town, using Lactobacillus GG or placebo in 204 infants, did not reveal any reduction in the duration of diarrheal episodes, but showed some advantage for infants who were not naturally breastfed. 22 The use of probiotics in the prevention of acute diarrhea was assessed in a meta-analysis published in 2006. 23 Nevertheless, only nine out of 28 studies included in the meta-analysis referred to infectious diarrhea (the remaining articles were about antibioticassociated diarrhea and traveler s diarrhea).…”

Section: Probiotics and Diarrheamentioning

confidence: 99%

O papel dos probióticos e prebióticos na prática pediátrica

Morais¹,

Jacob²

2006

J. Pediatr. (Rio J.)

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Objective: To review the effects of probiotics and prebiotics in clinical pediatric practice.Sources: MEDLINE was searched, especially for articles that addressed their practical application, in the form of reviews, clinical trials and meta-analyses. Articles that had already been analyzed by the authors were also included.Summary of the findings: Scientific literature on probiotics and prebiotics has remarkably increased in the last 10 years. Their mechanisms of action have been experimentally investigated. Studies indicate that probiotics can act by competing with pathogens, modifying the intestinal environment by reduction in pH, as a result of fermentation products, interacting and modulating local and systemic inflammatory and immune response, among others. Clinical trials and meta-analyses show that probiotics seem to contribute towards the prevention of acute diarrhea and of antibioticassociated diarrhea, in addition to shortening the duration of acute diarrhea. However, the data are inconsistent and there are no studies confirming their efficacy in terms of cost-benefit ratio. Preliminary studies show that probiotics in early life can reduce the occurrence of atopic dermatitis. The addition of prebiotics to infant formulas is associated with the change in the profile of the intestinal microbiota compared to infants fed milk formulas without prebiotics. Conclusions:Evidence indicates that new studies should be carried out about probiotics, prebiotics and symbiotics. The specific clinical effects that each probiotic or prebiotic may cause must be considered.J Pediatr (Rio J). 2006;82(5 Suppl):S189-97: Prebiotics, probiotics, symbiotics, lactobacillus, bifidobacteria, diarrhea. REVIEW ARTICLE

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A placebo-controlled trial of Lactobacillus GG to prevent diarrhea in undernourished Peruvian children

Cited by 245 publications

References 11 publications

Probiotics and health: An evidence-based review

Probiotics and health: An evidence-based review

Probiotics in Pediatrics – Properties, Mechanisms of Action, and Indications

O papel dos probióticos e prebióticos na prática pediátrica

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