A planar PDMS micropump using in-contact minimized-leakage check valves

Ni, Junhui; Huang, Fengliang; Wang, Bin; Li, Beizhi; Lin, Qiao

doi:10.1088/0960-1317/20/9/095033

Cited by 36 publications

(29 citation statements)

References 33 publications

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“…Pressurized nitrogen was used to drive DI water through the check valve in either forward or reverse direction, while the flow rate through the valve was obtained from the timed movement of the water meniscus in a plastic tubing connected to the exit end of the microchannel [24]. …”

Section: Methodsmentioning

confidence: 99%

A Microfluidic Approach to Pulsatile Delivery of Drugs for Neurobiological Studies

Wang

Litvin

et al. 2012

J. Microelectromech. Syst.

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We present an innovative microfluidic approach to transcranial delivery of small quantities of drugs in brief time pulses for neurobiological studies. The approach is based on a two-stage process of consecutive drug dispensing and delivery, demonstrated by a device featuring a fully planar design in which the microfluidic components are integrated in a single layer. This 2-D configuration offers ease in device fabrication and is compatible to diverse actuation schemes. A compliance-based and normally closed check valve is used to couple the microchannels that are responsible for drug dispensing and delivery. Brief pneumatic pressure pulses are used to mobilize buffer and drug solutions, which are injected via a cannula into brain tissue. Thus, the device can potentially allow transcranial drug delivery and can also be potentially extended to enable transdermal drug delivery. We have characterized the device by measuring the dispensed and delivered volumes under varying pneumatic driving pressures and pulse durations, the standby diffusive leakage, and the repeatability in the delivery of multiple pulses of drug solutions. Results demonstrate that the device is capable of accurately dispensing and delivering drug solutions 5 to 70 nL in volume within time pulses as brief as 50 ms, with negligible diffusive drug leakage over a practically relevant time scale. Furthermore, testing of pulsatile drug delivery into intact mouse brain tissue has been performed to demonstrate the potential application of the device to neurobiology.

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Section: Methodsmentioning

confidence: 99%

A Microfluidic Approach to Pulsatile Delivery of Drugs for Neurobiological Studies

Wang

Litvin

et al. 2012

J. Microelectromech. Syst.

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“…Micropumps are devices that can control and manipulate the flow of minute fluids volumes and their typical output flow rate varies in the range µL/min to mL/min [1,2]. Fabrication of such devices is of special interest in microfluidics research for medical application and has offered scope for industrial product integration in recent years.…”

Section: Introductionmentioning

confidence: 99%

“…Pan et al, studied PDMS membrane micropump with two one-way balls check valves for micro-fluidic applications where maximum flow rate of 774 μLmin −1 for 13 mW was observed and 10-turn planar coil pumping rate was 1 μLmin −1 for water [5]. Ni et al worked on PDMS with pneumatic actuation [1]. The micropump can generate maximum flow rate of 41μLmin −1 at 25kPa backpressure [1].…”

Section: Introductionmentioning

confidence: 99%

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Fabrication and development of magnetically actuated PDMS micropump for drug delivery

Gadad

Shivayyanavar

Viannie

et al. 2018

IOP Conf. Ser.: Mater. Sci. Eng.

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Abstract:Micropump is an essential component used in drug delivery systems to dispense small amounts of liquid into human body in a controlled manner over a period of time. Polydimethylsiloxane (PDMS) is an elastomeric polymer with attractive properties such as nontoxicity, biocompatibility and blood compatibility. Further, its bio-inertness inhibits microbial growth, thereby making it more attractive for biomedical applications. This paper presents the fabrication of a simple, dual-chamber, valveless PDMS micropump with an integrated magnetic actuator for drug delivery applications. The micropump developed in the laboratory consisted of two circular reservoirs provided with end nozzle diffusers. The reservoirs were sealed with a thin PDMS layer and a permanent magnet was attached over it to form the actuation membrane. An external magnet fixed to a rotating DC motor shaft is used to excite the actuation membrane. The magnetic force of attraction and repulsion between the rotating magnet and membrane magnet resulted in a vibrating diaphragm and consequently aids in pumping action. The liquid flow rate through the PDMS micropump depends on the rotational speed of the motor, viscosity of the liquid and the geometry of the micropump. Exhaustive experimental results were obtained with different viscous fluids such as water, ethanol and coconut oil. For these fluids, the motor speeds of the developed PDMS micropump worked satisfactorily. The parameter of interest such as flow rate for water was found to be 1.7 mL/min at a motor speed of 3000 rpm. The highest flow rate of the pump corresponded to the resonant frequency of the actuation membrane which is 14.8 Hz.

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“…In micropumps of the former type, a continuous movement of the fluid is induced by means of electrohydrodynamic (EHD), electrochemical, magnetohydrodynamic (MHD), electrophoretic, electroosmotic, or impedance driving forces [2–7]. By contrast, in reciprocating displacement micropumps, the fluid is driven peristaltically by applying an oscillatory or rotational movement to a series of (typically) three stationary diaphragms [8–14]. Reciprocating micropumps are typically actuated using piezoelectric [15,16], thermopneumatic [10,11,17], pneumatic [12–14,18], electromagnetic [19], or external actuation [20,21] techniques.…”

Section: Introductionmentioning

confidence: 99%

Electromagnetically-Actuated Reciprocating Pump for High-Flow-Rate Microfluidic Applications

Zhong

Lee

2012

Sensors

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This study presents an electromagnetically-actuated reciprocating pump for high-flow-rate microfluidic applications. The pump comprises four major components, namely a lower glass plate containing a copper microcoil, a middle PMMA plate incorporating a PDMS diaphragm with a surface-mounted magnet, upper PMMA channel plates, and a ball-type check valve located at the channel inlet. When an AC current is passed through the microcoil, an alternating electromagnetic force is established between the coil and the magnet. The resulting bi-directional deflection of the PDMS diaphragm causes the check-valve to open and close; thereby creating a pumping effect. The experimental results show that a coil input current of 0.4 A generates an electromagnetic force of 47 mN and a diaphragm deflection of 108 μm. Given an actuating voltage of 3 V and a driving frequency of 15 Hz, the flow rate is found to be 13.2 mL/min under zero head pressure conditions.

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A planar PDMS micropump using in-contact minimized-leakage check valves

Cited by 36 publications

References 33 publications

A Microfluidic Approach to Pulsatile Delivery of Drugs for Neurobiological Studies

A Microfluidic Approach to Pulsatile Delivery of Drugs for Neurobiological Studies

Fabrication and development of magnetically actuated PDMS micropump for drug delivery

Electromagnetically-Actuated Reciprocating Pump for High-Flow-Rate Microfluidic Applications

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