A planetary health perspective for kidney disease

Stenvinkel, Peter; Shiels, Paul G.; Painer, Johanna; Miranda, J. Jaime; Natterson-Horowitz, Barbara; Johnson, Richard J.

doi:10.1016/j.kint.2020.03.024

Cited by 14 publications

(9 citation statements)

References 18 publications

(33 reference statements)

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“…The large gap in knowledge on the bioavailability of bioactive nutrients also needs more attention. As dietary transitions toward greater consumption of healthier foods is also a way to improve environmental sustainability 25 , this is yet another reason to aim for the use of healthier food in a renal context and apply the "Planetary health" concept 26 .…”

Section: Introduction "Let Food Be Thy Medicine"mentioning

confidence: 99%

Food as medicine: targeting the uraemic phenotype in chronic kidney disease

et al. 2020

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stress and premature ageing are common features of the uremic phenotype.• The foodome -defined as the pool of all compounds present in a food sample and/or in a biological system interacting with the investigated food -can be implicated in the modulation of CKD complications.• Imbalance in the relative diversity of the gut microbiota has been studied extensively in CKD due its links with inflammation and cardiovascular risk. In this direction, researchers are evaluating the effects of pre-, pro-and synbiotics and many others food components like polyphenol-rich foods, sugar, proteins, etc. on both the modulation of the diversity of the gut microbiota and reduction in the levels of uremic toxins .• The use of bioactive compounds, found in curcumin, broccoli sprouts, berries, propolis, etc. may be valid nutritional therapeutic agents to modulate the expression of pro-inflammatory transcription factors, such as Nrf2, NF-kB and the inflammasome.• Senotherapeutic dietary compounds may mitigate the effects of a dysregulated ageing process in CKD and associated complications. including disturbed mitochondrial metabolism.Onion and garlic -may decrease NLRP3 activation Spinach -rich in betaine Green leafy vegetables -rich in folate Cruciferous vegetables, -rich in sulforaphane -may decrease NLRP3 activation, Nrf2 activators Some vegetables, such as spinach, broccoli, potatoes, cucumbers, green leafy -rich in potassium.

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Section: Introduction "Let Food Be Thy Medicine"mentioning

confidence: 99%

Food as medicine: targeting the uraemic phenotype in chronic kidney disease

et al. 2020

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“…[31,50,51] Accordingly, there has been an increasing demand for scientific research to cope with the expected changes in the spectrum of kidney disease and diagnosis, and for mitigating strategies in healthcare provision from the perspective of climate change. [52][53][54] Researchers in the US have published the most articles, ranking the US first in overall production. The US alone contributed >44% of all published articles about the effect of heat exposure on kidney health over the period specified above.…”

Section: Discussionmentioning

confidence: 99%

The impact of heat on kidney health: A PRISMA-compliant bibliometric analysis

Al-Bouwarthan¹,

AlMulla²,

Yaseen³

2022

Medicine

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Background: Exposure to excessive heat can impact kidney health. Climate change is projected to aggravate this impact. An analysis of articles published between 1958 and 2021 was conducted to explore the progress of the research on this issue.Methods: This study included a bibliometric analysis wherein Web of Science was used to generate a list of all published articles related to the impact of heat on kidney health. Basic information about the articles, such as titles, authors' names, keywords, and citations, were recorded and analyzed.Results: A total of 226 published articles related to the impact of heat on kidney health were identified as of November 20, 2021. Most of these articles (93%) were published within the last decade. The United States was the most prominent country in terms of research productivity and collaboration. Researchers from the United States were well represented among the top 20 contributors of published articles on the study issue. The productivity of the top 20 authors varied between 6 and 32 articles each. A total of 25 common words used by the authors were identified. The most frequently used keywords were chronic kidney disease, heat stress, acute kidney injury, Mesoamerican nephropathy, and climate change. Keyword analysis revealed 3 distinct major research clusters in the existing scientific research on the impact of heat on kidney health: chronic kidney disease of unknown etiology, heat stress and renal physiology, and the effect of climate change on kidney health.Conclusions: Research on heat-related kidney injury has witnessed rapid development in recent decades, motivated by the emergence of chronic kidney disease of unknown etiology and climate change. Developing countries in hot regions must increase their productivity in this research area through international collaboration and partnerships.Abbreviations: AKI = acute kidney injury, CKD = chronic kidney disease, CKDu = chronic kidney disease of unknown etiology, DALYs = disability-adjusted life years, LCS = local citation score, NP = number of published articles, SCP = single-country publications, TC = total citations, WoS = Web of Science.

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“…solutions to human health challenges derived from the natural world) to address this shortfall [ 1 , 25 ]. We have recently proposed the concept of ‘Planetary health'[ 62 ] which, in addition to the original manifesto by Horton et al [ 6 ], incorporates a biomimetic approach to improve human health span. Here we discuss how this may be achieved via direct modulation of human exposomes.…”

Section: Geo-physical and Social Environmentmentioning

confidence: 99%

Manipulating the exposome to enable better ageing

Shiels

Painer

Natterson-Horowitz

et al. 2021

Biochemical Journal

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The sum total of life course exposures creates an exposome that has a significant impact on age-related health. Understanding the interplay between exposome factors and the (epi) genome, offers pertinent insights into the ageing process and its relationship with the accumulation of allostatic load. We propose to exploit this to develop a biomimetic approach that will provide insight into how evolution through natural selection in other species has solved many age related human health issues. In particular, we will emphasise the need to reconnect a more mechanistic approach to medical science with a broader natural sciences approach, using biomimetics to mitigate the global burden of age related ill health. In particular, we will discuss how such an approach indicates leverage of the activities of the Nrf 2 gene to enhance health span via reintroduction of the classical ‘Food as Medicine’ concept, including modulation of the microbiome and the creation of more salutogenic and biophilic environments. Additionally, we will discuss how this approach integrates with novel and developing senotherapies.

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A planetary health perspective for kidney disease

Cited by 14 publications

References 18 publications

Food as medicine: targeting the uraemic phenotype in chronic kidney disease

Food as medicine: targeting the uraemic phenotype in chronic kidney disease

The impact of heat on kidney health: A PRISMA-compliant bibliometric analysis

Manipulating the exposome to enable better ageing

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