A plasmonic nanostructure fabricated by electron beam lithography as a sensitive and highly homogeneous SERS substrate for bio-sensing applications

Petti, Lucia; Capasso, Rossella; Rippa, Massimo; Pannico, Marianna; Manna, Pietro La; Peluso, Gianfranco; Calarco, Anna; Bobeico, E.; Musto, Pellegrino

doi:10.1016/j.vibspec.2015.11.007

Cited by 91 publications

(53 citation statements)

References 41 publications

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“…Gold, silver and other metals are commonly used in a SERS substrate due to their strong plasmonic resonance. 59 During the SERS measurement when the light source for example laser strikes the analyte attached with metal as schematically shown in 62 (b) Au triangular nanoprism SERS manufactured by e-beam lithography 63 (c) AuNSs SERS by nanolithography 64 (d) self-assembled gold nanosphere arrays 65 (e) aluminum nanocrystals 66 fabricated by chemical synthesis (f) AuNPs SERS by pen-andpaper approach. 67 A molecular trap structure based on gold-coated nanoscale polymer fingers as shown in Several other nanogap-rich structures such as Ag-ring arrays, 70 3D-Ag@ZnO nanostructures, 71 split-wedge antenna, 72 have been fabricated for SERS-based sensing.…”

Section: Sers Substrates and Sers Measurementmentioning

confidence: 99%

“…2 SERS, an effective label-free tool used for the detection of (a) different pollutants from a polluted sample 18 (b) pesticide residues attached to an apple. 19 ............. 63 (b) Au triangular nanoprism SERS manufactured by e-beam lithography 64 (c) AuNSs SERS by nanolithography 65 (d) self-assembled gold nanosphere arrays 66 (e) aluminum nanocrystals 67 fabricated by chemical synthesis (f) AuNPs SERS by pen-and-paper approach. 68 85 (b) simulated profile of Marangoni convection around a 1 μm microbubble 85 (c,d) SEM image of (c) patterned PS beads at different laser intensity; scale bar 5 µm (d) 3-D structure of aggregated PS beads; scale bar 1 µm (e) "BPL" and (f) "UT" pattern from PS beads (g, h) dark-field optical image of (g) 4 × 4 array of 3D hollow structures and (h) "SP" pattern of PS beads 85 ; scale bar in (e-h) 10 µm (i-k) "Mona Lisa" pattern of red QDs with fluorescence lifetime mapping 86 (l) fluorescence image of U.S. map depicting states of Texas, Pennsylvania, California printed with different QDs 86 (m) bright-field and dark-field optical image of an Ag ring array fabricated through BPL; scale bar 10 µm (n) SERS spectra of different concentration of R6G collected by Au ring array on AuNIs substrate.…”

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confidence: 99%

“…These type of structures can be also used for other applications, such as meta-materials, plasmonics, and other nanophotonic systems 62. SERS on an array of gold triangular nanoprisms with precisely controlled spacing and size as depicted inFigure 2.11 (b) has been fabricated through electron beam lithography technique and used for biosensing application 63. A large-scale homogeneous gold nanostars SERS substrates as illustrated inFigure 2.11 (c) has been fabricated by the combination of electroless deposition and block-copolymer micelle nanolithography and used for SERS imaging 64.…”

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confidence: 99%

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Active and Ultrasensitive Chemical and Biosensing through Optothermally Generated Microbubble

Karim

Sun

Vasquez

et al. 2020

Conference on Lasers and Electro-Optics

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Rapid and sensitive detection of harmful chemicals or biological samples is essential for medical study and industrial applications. For example, in the food industry, it is an urgent demand to detect hazardous chemicals or pathogens and then efficiently eliminate contaminated sources from the food production chain to protect people from toxic food-borne infection. In addition, toxic chemicals, pesticides and pathogens are also responsible for water, air and soil contamination. Therefore, rapid and sensitive detection of toxic chemicals or pathogens are very important to ensure food safety and evaluating environmental pollution. Most of the sensing systems for detecting chemical or biological samples apply a passive sensing method, in which binding of analytes to the sensor happens through free diffusion. Due to this free diffusion of analytes in a passive sensing method, diffusing process takes several hours even days, especially when the analytes are at low concentrations and therefore suffer from so called diffusion limit. A higher sensitivity can be achieved in passive sensing methods, with nanoscale sensors but at a cost of reduced speed and vice versa. Therefore, speed and sensitivity of sensing need to be traded off. Active sensing methods, in which analytes are actively concentrated towards the sensor, can be used to break the diffusion limit of sensing and significantly improve the sensitivity. In this work, an ultrasensitive and cost-effective chemical and biosensing platform has been developed under ambient condition to demonstrate active sensing of analytes. This method v works based on an optothermally generated microbubble (OGMB). OGMB is a micronsized bubble that is generated on a liquid-solid interface through laser heating. Due to the strong convective flow induced by OGMB, nanoparticles or analytes can be attracted towards the OGMB and deposited on the surface of a substrate. We have successfully fabricated nanogap-rich structures by generating an OGMB on a glass substrate. The nanoparticles in the nanogap-rich structures form many nanogaps that are ideal for surface enhance Raman scattering (SERS) due to the plasmonic resonance of nanogap-rich structures. Analytes for example any chemical or biological samples can be actively concentrated on the nanogap-rich structure for SERS detection. The OGMB-assisted active sensing method can improve the detection limit of analytes by an order of magnitude compared to that with a passive sensing and thus overcome the diffusion limit of conventional passive sensing methods. Therefore, we expect that, OGMB-assisted active sensing method will find potential applications in advanced chemical and bio-sensing. DEDICATION vi Dedicated to my mother who is my pride, inspiration, strength and my life. vii ACKNOWLEDGMENTS At the beginning, all the praise to Almighty for giving me the capability for successful completion of this work. I would like to express my sincere indebtedness to all who have given me the chance to finish this research. Without their generous sup...

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Section: Sers Substrates and Sers Measurementmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Active and Ultrasensitive Chemical and Biosensing through Optothermally Generated Microbubble

Karim

Sun

Vasquez

et al. 2020

Conference on Lasers and Electro-Optics

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“…Plasmonic nanostructures are useful to obtain novel nanodevices that use the shift of the spectral properties of plasmons as transducer element of a chemical/biological signal. Surface Enhanced Raman Scattering (SERS) is a well-known plasmonic spectroscopic technique that allows to reveal the vibrational modes (stretching, bending) of speci c chemical groups of molecules in touch with a SERS substrate [11][12][13][14][15][16][17][18][19]. In order to obtain a high ecient and speci c SERS bio-detection, it is necessary: a) to well design speci c nano-structured substrates with appropriated geometry and sizes; b) to appropriately choose chemicals that can speci cally interact with a target biomolecule.…”

Section: Introductionmentioning

confidence: 99%

“…It has been well-documented that SERS results from two e ects, electromagnetic eld enhancement caused by localized surface plasmon resonances (LSPR) associated with metallic nanostructures and chemical enhancement caused by resonance Raman-like interaction between the metallic nanostructure and the adsorbate. Large SERS signals are expected when both the frequency of the incident laser and the scattered Raman electromagnetic eld approach the resonance frequency of LSPR [14]. On the other hand, the spectral properties of the plasmonic resonance depend on the characteristic size of the pattern and they can be tuned by modi ng the lattice parameters.…”

Section: Introductionmentioning

confidence: 99%

Plasmonic Nanocavities-based Aperiodic crystal for Protein-Protein Recognition SERS sensors

Rippa¹,

Castagna²,

Pannico³

et al. 2017

Optical Data Processing and Storage

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Abstract:The revelation of protein-protein interactions is one of the main preoccupations in the eld of proteomics. Nanoplasmonics has emerged as an attractive surface-based technique because of its ability to sense protein binding under physiological conditions in a label-free manner. Here, we present a detailed experimental study of the use of aperiodic photonic nanocavities for plasmonic Surface Enhanced Raman Scattering (SERS) protein detection and recognition. The plasmonic crystal is designed on a 2D Thue-Morse array con guration. The SERS nanosensor is coated with a proper self-assembled monolayer to covalently bind Bovine Serum Albumin that is a well known model to study biological (speci cally, protein) systems. The performance of the nanosensor is assessed by recording a new Raman (SERS) peak in the ngerprint region and by a giant enhancement of the SERS signal intensity, both reported and discussed.

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Spectral Tuning of Plasmonic Activity in 3D Nanostructures via High‐Precision Nano‐Printing

Reisecker,

Kuhness,

Haberfehlner

et al. 2023

Adv Funct Materials

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Plasmonic nanoparticles reveal unique optical properties and are increasingly incorporated into commercial products and technologies, ranging from photovoltaics to biological and chemical sensors. Shifting and tuning their plasmonic response according to the targeted application strongly depends on the ability to control the geometry in every detail and has not been reliably demonstrated for complex 3D nano‐architectures yet. Following that motivation, it herein presents how Focused Electron Beam Induced Deposition (FEBID), a highly flexible additive 3D direct‐write technology with spatial nano‐scale precision, is used for the controlled and tunable fabrication of plasmonically active 3D nanostructures that exhibit highly concentrated, well defined and predictable local plasmonic resonances. As model systems, planar Au nanowires and 3D nano‐tips of various geometries are prepared via FEBID and plasmonically characterized via scanning transmission electron microscopy based electron energy loss spectroscopy (STEM‐EELS) mapping measurements. The findings are complemented with corresponding plasmon simulations, revealing very good agreement with experimental findings. This way, on‐demand spectral tuning of the plasmonic response becomes accessible via upfront modeling and design of suitable 3D nanostructures, to achieve customized plasmonic responses, therefore paving the way for yet unrealized plasmonic applications in 3D space.

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A plasmonic nanostructure fabricated by electron beam lithography as a sensitive and highly homogeneous SERS substrate for bio-sensing applications

Cited by 91 publications

References 41 publications

Active and Ultrasensitive Chemical and Biosensing through Optothermally Generated Microbubble

Active and Ultrasensitive Chemical and Biosensing through Optothermally Generated Microbubble

Plasmonic Nanocavities-based Aperiodic crystal for Protein-Protein Recognition SERS sensors

Spectral Tuning of Plasmonic Activity in 3D Nanostructures via High‐Precision Nano‐Printing

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