A Platform Technology for Monitoring the Unfolded Protein Response

Bachhav, Bhagyashree; Marmolejo, Carlos A. Origel; Arefeayne, Yafet; Segatori, Laura

doi:10.1007/978-1-0716-1732-8_4

Cited by 1 publication

(1 citation statement)

References 48 publications

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“…Moreover, many fluorescent reporter systems targeting UPR are used for drug screening (Iwawaki et al, 2004;Furukawa and Xiong, 2005;Lajoie et al, 2014;Chaveroux et al, 2015;Fu et al, 2015;Heman-Ackah et al, 2017a;Wu et al, 2018a;Grandjean et al, 2020;Santiago-Lopez et al, 2022b;Bachhav et al, 2022;Santiago-Lopez et al, 2022a;Carrillo et al, 2022;Kroukamp et al, 2022;Navarro-Tapia and Perez-Torrado, 2022). Although some effective compounds from chemical libraries or native products have been screened out, the direct targets and action mechanisms of these compounds are unclear.…”

Section: Discussionmentioning

confidence: 99%

Strategies targeting endoplasmic reticulum stress to improve Parkinson’s disease

Wang,

Qu,

Zhang

et al. 2023

Front. Pharmacol.

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Parkinson’s disease (PD) is a common neurodegenerative disorder with motor symptoms, which is caused by the progressive death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Accumulating evidence shows that endoplasmic reticulum (ER) stress occurring in the SNpc DA neurons is an early event in the development of PD. ER stress triggers the activation of unfolded protein response (UPR) to reduce stress and restore ER function. However, excessive and continuous ER stress and UPR exacerbate the risk of DA neuron death through crosstalk with other PD events. Thus, ER stress is considered a promising therapeutic target for the treatment of PD. Various strategies targeting ER stress through the modulation of UPR signaling, the increase of ER’s protein folding ability, and the enhancement of protein degradation are developed to alleviate neuronal death in PD models. In this review, we summarize the pathological role of ER stress in PD and update the strategies targeting ER stress to improve ER protein homeostasis and PD-related events.

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